登録情報 | データベース: PDB / ID: 2k7a |
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タイトル | Ensemble Structures of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase. |
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要素 | - SH2 domain of Tyrosine-protein kinase ITK/TSK
- SH3 domain of Tyrosine-protein kinase ITK/TSK
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キーワード | TRANSFERASE / SH3 / SH2 / novel / cis / ATP-binding / Cell membrane / Kinase / Membrane / Metal-binding / Nucleotide-binding / Phosphoprotein / SH2 domain / SH3 domain / Tyrosine-protein kinase / Zinc / Zinc-finger |
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機能・相同性 | 機能・相同性情報
Generation of second messenger molecules / FCERI mediated Ca+2 mobilization / gamma-delta T cell activation / NK T cell differentiation / : / positive regulation of cytokine production / B cell receptor signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / cell-cell junction ...Generation of second messenger molecules / FCERI mediated Ca+2 mobilization / gamma-delta T cell activation / NK T cell differentiation / : / positive regulation of cytokine production / B cell receptor signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / cell-cell junction / T cell receptor signaling pathway / adaptive immune response / intracellular signal transduction / protein phosphorylation / ATP binding / nucleus / metal ion binding / plasma membrane / cytosol類似検索 - 分子機能 Tyrosine-protein kinase ITK, SH3 domain / Tyrosine-protein kinase ITK/TSK, catalytic domain / Zinc finger, Btk motif / BTK motif / Zinc finger Btk-type profile. / Bruton's tyrosine kinase Cys-rich motif / SH2 domain / SHC Adaptor Protein / SH3 Domains / : ...Tyrosine-protein kinase ITK, SH3 domain / Tyrosine-protein kinase ITK/TSK, catalytic domain / Zinc finger, Btk motif / BTK motif / Zinc finger Btk-type profile. / Bruton's tyrosine kinase Cys-rich motif / SH2 domain / SHC Adaptor Protein / SH3 Domains / : / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH3 type barrels. / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / PH-like domain superfamily / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Roll / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Andreotti, A.H. / Severin, A.J. / Fulton, D.B. |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2009 タイトル: Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain. 著者: Severin, A. / Joseph, R.E. / Boyken, S. / Fulton, D.B. / Andreotti, A.H. |
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履歴 | 登録 | 2008年8月8日 | 登録サイト: BMRB / 処理サイト: PDBJ |
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改定 1.0 | 2009年3月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2020年1月1日 | Group: Database references / Derived calculations カテゴリ: citation / citation_author ...citation / citation_author / pdbx_struct_assembly / pdbx_struct_assembly_prop / pdbx_struct_oper_list / struct_ref_seq_dif Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name / _struct_ref_seq_dif.details |
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改定 1.3 | 2024年5月1日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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