Entry Database : PDB / ID : 2iwg Structure visualization Downloads & linksTitle COMPLEX BETWEEN THE PRYSPRY DOMAIN OF TRIM21 AND IGG FC Components52 KDA RO PROTEIN IG GAMMA-1 CHAIN C DetailsKeywords IMMUNOGLOBULIN DOMAIN / ZINC / RNA-BINDING / ZINC-FINGER / DNA-BINDING / RIBONUCLEOPROTEIN / IMMUNOGLOBULIN C REGION / SYSTEMIC LUPUS ERYTHEMATOSUS / POLYMORPHISM / GLYCOPROTEIN / METAL-BINDINGFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of protein deubiquitination / regulation of viral entry into host cell / protein K27-linked ubiquitination / suppression of viral release by host / regulation of type I interferon production / cellular response to chemical stress / negative regulation of viral transcription / protein K6-linked ubiquitination / STING mediated induction of host immune responses / complement-dependent cytotoxicity ... negative regulation of protein deubiquitination / regulation of viral entry into host cell / protein K27-linked ubiquitination / suppression of viral release by host / regulation of type I interferon production / cellular response to chemical stress / negative regulation of viral transcription / protein K6-linked ubiquitination / STING mediated induction of host immune responses / complement-dependent cytotoxicity / stress granule disassembly / antibody-dependent cellular cytotoxicity / Fc-gamma receptor I complex binding / Classical antibody-mediated complement activation / IgG immunoglobulin complex / Initial triggering of complement / negative regulation of NF-kappaB transcription factor activity / response to type II interferon / pyroptotic inflammatory response / protein monoubiquitination / protein K63-linked ubiquitination / FCGR activation / autophagosome / Role of phospholipids in phagocytosis / immunoglobulin complex, circulating / protein autoubiquitination / protein K48-linked ubiquitination / immunoglobulin receptor binding / positive regulation of autophagy / positive regulation of cell cycle / Regulation of innate immune responses to cytosolic DNA / negative regulation of innate immune response / proteasomal protein catabolic process / complement activation, classical pathway / FCGR3A-mediated IL10 synthesis / antigen binding / Regulation of Complement cascade / FCGR3A-mediated phagocytosis / B cell receptor signaling pathway / P-body / protein destabilization / RING-type E3 ubiquitin transferase / Regulation of actin dynamics for phagocytic cup formation / positive regulation of DNA-binding transcription factor activity / cytoplasmic stress granule / protein polyubiquitination / ubiquitin-protein transferase activity / regulation of protein localization / KEAP1-NFE2L2 pathway / Interferon gamma signaling / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / positive regulation of protein binding / cytoplasmic vesicle / antibacterial humoral response / Interleukin-4 and Interleukin-13 signaling / positive regulation of canonical NF-kappaB signal transduction / adaptive immune response / blood microparticle / positive regulation of viral entry into host cell / transcription coactivator activity / protein ubiquitination / ribonucleoprotein complex / cell cycle / innate immune response / protein kinase binding / protein homodimerization activity / DNA binding / extracellular space / RNA binding / extracellular exosome / zinc ion binding / extracellular region / nucleoplasm / identical protein binding / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function TRIM21, PRY/SPRY domain / Zinc finger, B-box, chordata / SPRY domain / SPRY-associated domain / SPRY-associated / PRY / Butyrophylin-like, SPRY domain / Modified RING finger domain / U-box domain / B-box zinc finger ... TRIM21, PRY/SPRY domain / Zinc finger, B-box, chordata / SPRY domain / SPRY-associated domain / SPRY-associated / PRY / Butyrophylin-like, SPRY domain / Modified RING finger domain / U-box domain / B-box zinc finger / B-Box-type zinc finger / B-box-type zinc finger / Zinc finger B-box type profile. / Zinc finger, C3HC4 RING-type / Zinc finger, C3HC4 type (RING finger) / SPRY domain / B30.2/SPRY domain / B30.2/SPRY domain profile. / SPRY domain / B30.2/SPRY domain superfamily / Domain in SPla and the RYanodine Receptor. / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Ring finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Concanavalin A-like lectin/glucanase domain superfamily / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Zinc finger, RING/FYVE/PHD-type / Jelly Rolls / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / OTHER / Resolution : 2.35 Å DetailsAuthors James, L.C. / Keeble, A.H. / Rhodes, D.A. / Trowsdale, J. CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2007Title : Structural Basis for Pryspry-Mediated Tripartite Motif (Trim) Protein Function.Authors : James, L.C. / Keeble, A.H. / Khan, Z. / Rhodes, D.A. / Trowsdale, J. History Deposition Jun 30, 2006 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 27, 2007 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 2.0 Nov 15, 2017 Group : Advisory / Atomic model ... Advisory / Atomic model / Derived calculations / Non-polymer description / Structure summary Category : atom_site / entity ... atom_site / entity / pdbx_unobs_or_zero_occ_atoms / struct_conn / struct_site_gen Item : _atom_site.auth_comp_id / _atom_site.label_comp_id ... _atom_site.auth_comp_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _chem_comp.formula / _chem_comp.id / _chem_comp.name / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_label_comp_id / _struct_site_gen.auth_comp_id / _struct_site_gen.label_comp_id Revision 3.0 Jul 29, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Derived calculations / Other / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_database_status / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_unobs_or_zero_occ_atoms / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_database_status.status_code_sf / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_unobs_or_zero_occ_atoms.label_asym_id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_comp_id Description : Carbohydrate remediation / Provider : repository / Type : Remediation
Show all Show less Remark 700 SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.