- PDB-1cww: SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM ... -
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基本情報
登録情報
データベース: PDB / ID: 1cww
タイトル
SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM APAF-1
要素
APOPTOTIC PROTEASE ACTIVATING FACTOR 1
キーワード
APOPTOSIS (アポトーシス) / HELICAL BUNDLE (ヘリックスバンドル)
機能・相同性
機能・相同性情報
response to G1 DNA damage checkpoint signaling / Formation of apoptosome / regulation of apoptotic DNA fragmentation / アポトソーム / activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / Regulation of the apoptosome activity / Activation of caspases through apoptosome-mediated cleavage / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / TP53 Regulates Transcription of Caspase Activators and Caspases ...response to G1 DNA damage checkpoint signaling / Formation of apoptosome / regulation of apoptotic DNA fragmentation / アポトソーム / activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / Regulation of the apoptosome activity / Activation of caspases through apoptosome-mediated cleavage / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / TP53 Regulates Transcription of Caspase Activators and Caspases / Transcriptional Regulation by E2F6 / cysteine-type endopeptidase activator activity involved in apoptotic process / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / forebrain development / positive regulation of apoptotic signaling pathway / cardiac muscle cell apoptotic process / cellular response to transforming growth factor beta stimulus / heat shock protein binding / intrinsic apoptotic signaling pathway / response to nutrient / kidney development / neural tube closure / ADP binding / activation of cysteine-type endopeptidase activity involved in apoptotic process / nervous system development / neuron apoptotic process / secretory granule lumen / regulation of apoptotic process / ficolin-1-rich granule lumen / 細胞分化 / response to hypoxia / positive regulation of apoptotic process / nucleotide binding / apoptotic process / Neutrophil degranulation / protein-containing complex / extracellular exosome / extracellular region / ATP binding / identical protein binding / 細胞核 / 細胞質基質 類似検索 - 分子機能
手法: DISTANCE GEOMETRY TORSION ANGLE DYNAMICS SIMULATED ANNEALING ソフトェア番号: 1 詳細: THE STRUCTURES ARE BASED ON A TOTAL OF 2314 NOE-DERIVED DISTANCE CONSTRAINTS, 31 HYDROGEN BOND CONSTRAINTS AND 173 DIHEDRAL ANGLE CONSTRAINTS.
代表構造
選択基準: closest to the average
NMRアンサンブル
コンフォーマー選択の基準: STRUCTURES WITH THE LEAST RESTRAINT VIOLATIONS,STRUCTURES WITH THE LOWEST ENERGY 計算したコンフォーマーの数: 250 / 登録したコンフォーマーの数: 20