Channel / receptor (受容体) / MEMBRANE PROTEIN (膜タンパク質)
機能・相同性
機能・相同性情報
negative regulation of dendritic spine development / excitatory chemical synaptic transmission / Synaptic adhesion-like molecules / propylene metabolic process / response to glycine / regulation of monoatomic cation transmembrane transport / glutamate receptor activity / Assembly and cell surface presentation of NMDA receptors / Neurexins and neuroligins / NMDA glutamate receptor activity ...negative regulation of dendritic spine development / excitatory chemical synaptic transmission / Synaptic adhesion-like molecules / propylene metabolic process / response to glycine / regulation of monoatomic cation transmembrane transport / glutamate receptor activity / Assembly and cell surface presentation of NMDA receptors / Neurexins and neuroligins / NMDA glutamate receptor activity / NMDA selective glutamate receptor complex / glutamate-gated calcium ion channel activity / calcium ion transmembrane import into cytosol / protein heterotetramerization / glutamate binding / positive regulation of reactive oxygen species biosynthetic process / glycine binding / positive regulation of calcium ion transport into cytosol / Negative regulation of NMDA receptor-mediated neuronal transmission / monoatomic cation transmembrane transport / dendrite development / Unblocking of NMDA receptors, glutamate binding and activation / regulation of neuronal synaptic plasticity / positive regulation of excitatory postsynaptic potential / 長期増強 / monoatomic cation transport / ligand-gated monoatomic ion channel activity / excitatory synapse / calcium ion homeostasis / prepulse inhibition / synaptic cleft / EPHB-mediated forward signaling / presynaptic modulation of chemical synaptic transmission / ionotropic glutamate receptor signaling pathway / excitatory postsynaptic potential / Ras activation upon Ca2+ influx through NMDA receptor / positive regulation of synaptic transmission, glutamatergic / protein phosphatase 2A binding / synaptic membrane / synaptic transmission, glutamatergic / regulation of membrane potential / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / postsynaptic density membrane / calcium channel activity / regulation of synaptic plasticity / brain development / visual learning / modulation of chemical synaptic transmission / terminal bouton / calcium ion transport / rhythmic process / シナプス小胞 / presynapse / signaling receptor activity / amyloid-beta binding / RAF/MAP kinase cascade / chemical synaptic transmission / postsynaptic membrane / response to ethanol / 樹状突起スパイン / postsynaptic density / calmodulin binding / neuron projection / neuronal cell body / glutamatergic synapse / シナプス / 樹状突起 / calcium ion binding / protein-containing complex binding / endoplasmic reticulum membrane / 細胞膜 / positive regulation of transcription by RNA polymerase II / 生体膜 / identical protein binding / 細胞膜 / 細胞質 類似検索 - 分子機能
Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / リガンド依存性イオンチャネル / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor / Eukaryotic homologues of bacterial periplasmic substrate binding proteins. ...Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / リガンド依存性イオンチャネル / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor / Eukaryotic homologues of bacterial periplasmic substrate binding proteins. / Receptor, ligand binding region / Receptor family ligand binding region / Periplasmic binding protein-like I 類似検索 - ドメイン・相同性
National Institutes of Health/National Institute of Mental Health (NIH/NIMH)
NS11745
米国
National Institutes of Health/National Institute of Mental Health (NIH/NIMH)
MH085926
米国
National Institutes of Health/National Institute of Mental Health (NIH/NIMH)
F32MH121061
米国
National Institutes of Health/National Institute of Mental Health (NIH/NIMH)
NS113632
米国
引用
ジャーナル: Sci Adv / 年: 2024 タイトル: Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel. 著者: Kevin Michalski / Hiro Furukawa / 要旨: -methyl-d-aspartate receptors (NMDARs) and other ionotropic glutamate receptors (iGluRs) mediate most of the excitatory signaling in the mammalian brains in response to the neurotransmitter glutamate. ...-methyl-d-aspartate receptors (NMDARs) and other ionotropic glutamate receptors (iGluRs) mediate most of the excitatory signaling in the mammalian brains in response to the neurotransmitter glutamate. Uniquely, NMDARs composed of GluN1 and GluN3 are activated exclusively by glycine, the neurotransmitter conventionally mediating inhibitory signaling when it binds to pentameric glycine receptors. The GluN1-3 NMDARs are vital for regulating neuronal excitability, circuit function, and specific behaviors, yet our understanding of their functional mechanism at the molecular level has remained limited. Here, we present cryo-electron microscopy structures of GluN1-3A NMDARs bound to an antagonist, CNQX, and an agonist, glycine. The structures show a 1-3-1-3 subunit heterotetrameric arrangement and an unprecedented pattern of GluN3A subunit orientation shift between the glycine-bound and CNQX-bound structures. Site-directed disruption of the unique subunit interface in the glycine-bound structure mitigated desensitization. Our study provides a foundation for understanding the distinct structural dynamics of GluN3 that are linked to the unique function of GluN1-3 NMDARs.