+Open data
-Basic information
Entry | Database: PDB / ID: 4inu | ||||||
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Title | Yeast 20S proteasome in complex with the vinyl sulfone LU112 | ||||||
Components | (Proteasome component ...) x 14 | ||||||
Keywords | HYDROLASE/HYDROLASE INHIBITOR / UPS / drug discovery / irreversible inhibition / Ntn hydrolase / non-lysosomal protein breakdown / HYDROLASE-HYDROLASE INHIBITOR complex | ||||||
Function / homology | Function and homology information proteasome core complex assembly / nuclear outer membrane-endoplasmic reticulum membrane network / Cross-presentation of soluble exogenous antigens (endosomes) / TNFR2 non-canonical NF-kB pathway / proteasomal ubiquitin-independent protein catabolic process / Ub-specific processing proteases / proteasome storage granule / endopeptidase activator activity / proteasome assembly / proteasome endopeptidase complex ...proteasome core complex assembly / nuclear outer membrane-endoplasmic reticulum membrane network / Cross-presentation of soluble exogenous antigens (endosomes) / TNFR2 non-canonical NF-kB pathway / proteasomal ubiquitin-independent protein catabolic process / Ub-specific processing proteases / proteasome storage granule / endopeptidase activator activity / proteasome assembly / proteasome endopeptidase complex / proteasome core complex, beta-subunit complex / proteasome core complex, alpha-subunit complex / threonine-type endopeptidase activity / Neutrophil degranulation / proteasome complex / proteasomal protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / endopeptidase activity / mRNA binding / endoplasmic reticulum membrane / mitochondrion / nucleus / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | Saccharomyces cerevisiae (brewer's yeast) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.1 Å | ||||||
Authors | Geurink, P.P. / van der Linden, W.A. / Mirabella, A.C. / Gallastegui, N. / de Bruin, G. / Blom, A.E.M. / Voges, M.J. / Mock, E.D. / Florea, B.I. / van der Marel, G.A. ...Geurink, P.P. / van der Linden, W.A. / Mirabella, A.C. / Gallastegui, N. / de Bruin, G. / Blom, A.E.M. / Voges, M.J. / Mock, E.D. / Florea, B.I. / van der Marel, G.A. / Driessen, C. / van der Stelt, M. / Groll, M. / Overkleeft, H.S. / Kisselev, A.F. | ||||||
Citation | Journal: J.Med.Chem. / Year: 2013 Title: Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites. Authors: Geurink, P.P. / van der Linden, W.A. / Mirabella, A.C. / Gallastegui, N. / de Bruin, G. / Blom, A.E. / Voges, M.J. / Mock, E.D. / Florea, B.I. / van der Marel, G.A. / Driessen, C. / van der ...Authors: Geurink, P.P. / van der Linden, W.A. / Mirabella, A.C. / Gallastegui, N. / de Bruin, G. / Blom, A.E. / Voges, M.J. / Mock, E.D. / Florea, B.I. / van der Marel, G.A. / Driessen, C. / van der Stelt, M. / Groll, M. / Overkleeft, H.S. / Kisselev, A.F. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 4inu.cif.gz | 2.4 MB | Display | PDBx/mmCIF format |
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PDB format | pdb4inu.ent.gz | 2 MB | Display | PDB format |
PDBx/mmJSON format | 4inu.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/in/4inu ftp://data.pdbj.org/pub/pdb/validation_reports/in/4inu | HTTPS FTP |
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-Related structure data
Related structure data | 4inrC 4intC 1rypS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: 1 / Refine code: 4
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