Entry Database : PDB / ID : 3kq4 Structure visualization Downloads & linksTitle Structure of Intrinsic Factor-Cobalamin bound to its receptor Cubilin ComponentsCubilin Gastric intrinsic factor DetailsKeywords TRANSPORT PROTEIN / PROTEIN-PROTEIN COMPLEX / Cobalt / Cobalt transport / Disease mutation / Disulfide bond / Glycoprotein / Secreted / Transport / Cholesterol metabolism / Cobalamin / EGF-like domain / Endocytosis / Endosome / Lipid metabolism / Lysosome / Membrane / Protein transport / Receptor / Steroid metabolismFunction / homology Function and homology informationFunction Domain/homology Component
Defective CBLIF causes IFD / Defective AMN causes MGA1 / Defective CUBN causes MGA1 / cargo receptor ligand activity / cobalamin metabolic process / Uptake of dietary cobalamins into enterocytes / HDL clearance / cobalt ion transport / extrinsic component of external side of plasma membrane / cobalamin transport ... Defective CBLIF causes IFD / Defective AMN causes MGA1 / Defective CUBN causes MGA1 / cargo receptor ligand activity / cobalamin metabolic process / Uptake of dietary cobalamins into enterocytes / HDL clearance / cobalt ion transport / extrinsic component of external side of plasma membrane / cobalamin transport / lipoprotein transport / Vitamin D (calciferol) metabolism / tissue homeostasis / cobalamin binding / cargo receptor activity / microvillus membrane / microvillus / endocytic vesicle / clathrin-coated pit / cholesterol metabolic process / lysosomal lumen / receptor-mediated endocytosis / establishment of localization in cell / brush border membrane / response to bacterium / signaling receptor activity / receptor complex / endosome / apical plasma membrane / lysosomal membrane / calcium ion binding / Golgi apparatus / endoplasmic reticulum / protein homodimerization activity / extracellular space / extracellular exosome / extracellular region / membrane / plasma membrane / cytosol Similarity search - Function Ferric Hydroxamate Uptake Protein; Chain A, domain 1 - #30 / : / Domain of unknown function (DUF4430) / Cobalamin (vitamin B12)-binding protein / Eukaryotic cobalamin-binding protein / Eukaryotic cobalamin-binding proteins signature. / Spermadhesin, CUB domain / EGF domain / EGF domain / Ferric Hydroxamate Uptake Protein; Chain A, domain 1 ... Ferric Hydroxamate Uptake Protein; Chain A, domain 1 - #30 / : / Domain of unknown function (DUF4430) / Cobalamin (vitamin B12)-binding protein / Eukaryotic cobalamin-binding protein / Eukaryotic cobalamin-binding proteins signature. / Spermadhesin, CUB domain / EGF domain / EGF domain / Ferric Hydroxamate Uptake Protein; Chain A, domain 1 / CUB domain / Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. / CUB domain / CUB domain profile. / Spermadhesin, CUB domain superfamily / Glycosyltransferase - #20 / Calcium-binding EGF domain / Glycosyltransferase / Alpha/alpha barrel / EGF-like domain / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Growth factor receptor cysteine-rich domain superfamily / Epidermal growth factor-like domain. / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Beta Complex / Jelly Rolls / Sandwich / Mainly Beta / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.3 Å DetailsAuthors Andersen, C.B.F. / Madsen, M. / Moestrup, S.K. / Andersen, G.R. CitationJournal : Nature / Year : 2010Title : Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes.Authors : Andersen, C.B. / Madsen, M. / Storm, T. / Moestrup, S.K. / Andersen, G.R. History Deposition Nov 17, 2009 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 9, 2010 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Oct 24, 2012 Group : Non-polymer descriptionRevision 1.3 Mar 7, 2018 Group : Advisory / Data collection / Category : diffrn_source / pdbx_unobs_or_zero_occ_atoms / Item : _diffrn_source.pdbx_synchrotron_siteRevision 2.0 Jul 29, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Derived calculations / Structure summary Category : atom_site / atom_site_anisotrop ... atom_site / atom_site_anisotrop / chem_comp / database_PDB_caveat / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.occupancy / _atom_site.type_symbol / _atom_site_anisotrop.U[1][1] / _atom_site_anisotrop.U[1][2] / _atom_site_anisotrop.U[1][3] / _atom_site_anisotrop.U[2][2] / _atom_site_anisotrop.U[2][3] / _atom_site_anisotrop.U[3][3] / _atom_site_anisotrop.pdbx_auth_asym_id / _atom_site_anisotrop.pdbx_auth_atom_id / _atom_site_anisotrop.pdbx_auth_comp_id / _atom_site_anisotrop.pdbx_auth_seq_id / _atom_site_anisotrop.pdbx_label_asym_id / _atom_site_anisotrop.pdbx_label_atom_id / _atom_site_anisotrop.pdbx_label_comp_id / _atom_site_anisotrop.type_symbol / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_comp_id Description : Carbohydrate remediation / Provider : repository / Type : Remediation
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