登録情報 データベース : PDB / ID : 7qgs 構造の表示 ダウンロードとリンクタイトル Crystal structure of p300 CH1 domain in complex with CITIF (a CITED2-HIF-1alpha hybrid) 要素Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha Histone acetyltransferase ヒストンアセチルトランスフェラーゼ 詳細キーワード PROTEIN BINDING (タンパク質) / hypoxia / transcription factor (転写因子) / intrinsically disordered protein (天然変性タンパク質)機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
cranial nerve morphogenesis / TFAP2 (AP-2) family regulates transcription of other transcription factors / embryonic process involved in female pregnancy / left/right pattern formation / pulmonary artery morphogenesis / epithelial cell differentiation involved in mammary gland alveolus development / embryonic heart tube left/right pattern formation / neural fold elevation formation / regulation of animal organ formation / adrenal cortex formation ... cranial nerve morphogenesis / TFAP2 (AP-2) family regulates transcription of other transcription factors / embryonic process involved in female pregnancy / left/right pattern formation / pulmonary artery morphogenesis / epithelial cell differentiation involved in mammary gland alveolus development / embryonic heart tube left/right pattern formation / neural fold elevation formation / regulation of animal organ formation / adrenal cortex formation / iris morphogenesis / nodal signaling pathway / positive regulation of chemokine-mediated signaling pathway / hypoxia-inducible factor-1alpha signaling pathway / embryonic camera-type eye morphogenesis / elastin metabolic process / glandular epithelial cell maturation / sex determination / regulation of transforming growth factor beta2 production / positive regulation of male gonad development / endocardial cushion development / connective tissue replacement involved in inflammatory response wound healing / determination of left/right asymmetry in lateral mesoderm / cardiac ventricle morphogenesis / negative regulation of mesenchymal cell apoptotic process / positive regulation of peroxisome proliferator activated receptor signaling pathway / hemoglobin biosynthetic process / granulocyte differentiation / retina vasculature development in camera-type eye / lens morphogenesis in camera-type eye / left/right axis specification / positive regulation of hormone biosynthetic process / mesenchymal cell apoptotic process / positive regulation of mitophagy / positive regulation of cell-cell adhesion / Cellular response to hypoxia / negative regulation of cardiac muscle cell proliferation / intestinal epithelial cell maturation / negative regulation of growth / regulation of protein neddylation / collagen metabolic process / PTK6 Expression / lactate metabolic process / intracellular oxygen homeostasis / negative regulation of bone mineralization / response to fluid shear stress / trophectodermal cell differentiation / B-1 B cell homeostasis / vascular endothelial growth factor production / peripheral nervous system development / negative regulation of TOR signaling / cardiac neural crest cell development involved in heart development / negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / transcription regulator activator activity / STAT3 nuclear events downstream of ALK signaling / dopaminergic neuron differentiation / Activation of the TFAP2 (AP-2) family of transcription factors / positive regulation of cytokine production involved in inflammatory response / 繊毛 / negative regulation of thymocyte apoptotic process / positive regulation of vascular endothelial growth factor receptor signaling pathway / bone morphogenesis / positive regulation of signaling receptor activity / insulin secretion involved in cellular response to glucose stimulus / response to iron ion / determination of left/right symmetry / response to muscle activity / 神経堤 / Regulation of gene expression by Hypoxia-inducible Factor / embryonic hemopoiesis / regulation of glycolytic process / erythrocyte development / histone acetyltransferase binding / FOXO-mediated transcription of cell death genes / PTK6 promotes HIF1A stabilization / digestive tract morphogenesis / muscle cell cellular homeostasis / regulation of aerobic respiration / DNA-binding transcription repressor activity / DNA-binding transcription activator activity / positive regulation of neuroblast proliferation / ventricular septum morphogenesis / axonal transport of mitochondrion / positive regulation of epithelial cell migration / heart looping / LBD domain binding / bone mineralization / MTOR / E-box binding / outflow tract morphogenesis / positive regulation of transforming growth factor beta receptor signaling pathway / skeletal muscle cell differentiation / intracellular glucose homeostasis / SMAD binding / positive regulation of insulin secretion involved in cellular response to glucose stimulus / uterus development / decidualization / neuroblast proliferation / positive regulation of vascular endothelial growth factor production / negative regulation of reactive oxygen species metabolic process 類似検索 - 分子機能 参照 (書誌学) / 参照 (書誌学) / Hypoxia-inducible factor-1 alpha / HIF-1 alpha, transactivation domain, C-terminal / HIF-1 alpha C terminal transactivation domain / Hypoxia-inducible factor, alpha subunit-like / 低酸素誘導因子 / PAS fold-3 / PAS fold / Zinc finger, TAZ-type ... 参照 (書誌学) / 参照 (書誌学) / Hypoxia-inducible factor-1 alpha / HIF-1 alpha, transactivation domain, C-terminal / HIF-1 alpha C terminal transactivation domain / Hypoxia-inducible factor, alpha subunit-like / 低酸素誘導因子 / PAS fold-3 / PAS fold / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / Coactivator CBP, KIX domain / CREB-binding protein/p300, atypical RING domain / CBP/p300-type histone acetyltransferase domain / CBP/p300, atypical RING domain superfamily / KIX domain / CREB-binding protein/p300, atypical RING domain / KIX domain profile. / CBP/p300-type histone acetyltransferase (HAT) domain profile. / Coactivator CBP, KIX domain superfamily / Histone acetyltransferase Rtt109/CBP / Histone acetylation protein / Histone acetylation protein / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / PAS fold / PAS fold / PAS domain / PAS repeat profile. / PAS domain / PAS domain superfamily / Bromodomain, conserved site / Bromodomain signature. / ブロモドメイン / Bromodomain profile. / bromo domain / ブロモドメイン / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type 類似検索 - ドメイン・相同性 Hypoxia-inducible factor 1-alpha / ヒストンアセチルトランスフェラーゼ / Cbp/p300-interacting transactivator 2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2 Å 詳細データ登録者 Hegedus, Z. / Wilson, A.J. / Edwards, T.A. 資金援助 英国, 6件 詳細 詳細を隠す組織 認可番号 国 Engineering and Physical Sciences Research Council EP/N013573/1 英国 Engineering and Physical Sciences Research Council EP/KO39292/1 英国 Engineering and Physical Sciences Research Council BB/L01386X/1 英国 H2020 Marie Curie Actions of the European Commission MSCA-IF-2016-749012 英国 Hungarian National Research, Development and Innovation Office NKFIH PD 135324 英国 Royal Society 191087 英国
引用ジャーナル : Rsc Chem Biol / 年 : 2022タイトル : Understanding p300-transcription factor interactions using sequence variation and hybridization.著者 : Hobor, F. / Hegedus, Z. / Ibarra, A.A. / Petrovicz, V.L. / Bartlett, G.J. / Sessions, R.B. / Wilson, A.J. / Edwards, T.A. 履歴 登録 2021年12月10日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2022年5月11日 Provider : repository / タイプ : Initial release改定 1.1 2022年6月15日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID 改定 1.2 2024年1月31日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
すべて表示 表示を減らす