登録情報 | データベース: PDB / ID: 6tns |
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タイトル | PI3K delta in complex with 2methoxyN[2methoxy5(7{[(2R)4(oxetan3 yl)morpholin2yl]methoxy}1,3dihydro2 benzofuran5yl)pyridin3yl]ethane1 sulfonamide |
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要素 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform |
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キーワード | TRANSFERASE (転移酵素) / PI3 Kinase Structure based design |
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機能・相同性 | 機能・相同性情報
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / Interleukin receptor SHC signaling / Synthesis of PIPs at the plasma membrane / PIP3 activates AKT signaling / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / Regulation of signaling by CBL / positive regulation of cell migration by vascular endothelial growth factor signaling pathway / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Interleukin-3, Interleukin-5 and GM-CSF signaling / RET signaling ...Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / Interleukin receptor SHC signaling / Synthesis of PIPs at the plasma membrane / PIP3 activates AKT signaling / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / Regulation of signaling by CBL / positive regulation of cell migration by vascular endothelial growth factor signaling pathway / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Interleukin-3, Interleukin-5 and GM-CSF signaling / RET signaling / positive regulation of epithelial tube formation / positive regulation of neutrophil apoptotic process / phosphatidylinositol 3-kinase complex / 1-phosphatidylinositol-4-phosphate 3-kinase activity / 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity / phosphatidylinositol-4,5-bisphosphate 3-kinase / PI3キナーゼ / phosphatidylinositol 3-kinase complex, class IA / phosphatidylinositol-3-phosphate biosynthetic process / 1-phosphatidylinositol-3-kinase activity / B cell activation / B cell homeostasis / homeostasis of number of cells / defense response to fungus / positive regulation of endothelial cell proliferation / positive regulation of endothelial cell migration / phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of angiogenesis / 走化性 / kinase activity / 獲得免疫系 / 細胞分化 / cell surface receptor signaling pathway / positive regulation of cell migration / 炎症 / リン酸化 / negative regulation of gene expression / 自然免疫系 / positive regulation of gene expression / ATP binding / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 PI3Kdelta, catalytic domain / PI3-kinase family, p85-binding domain / PI3-kinase family, p85-binding domain / Phosphatidylinositol 3-kinase, adaptor-binding domain / Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain profile. / PI3-kinase family, Ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain / PI3-kinase family, ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain profile. / Phosphoinositide 3-kinase C2 ...PI3Kdelta, catalytic domain / PI3-kinase family, p85-binding domain / PI3-kinase family, p85-binding domain / Phosphatidylinositol 3-kinase, adaptor-binding domain / Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain profile. / PI3-kinase family, Ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain / PI3-kinase family, ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain profile. / Phosphoinositide 3-kinase C2 / Phosphoinositide 3-kinase, region postulated to contain C2 domain / C2 phosphatidylinositol 3-kinase-type domain / C2 phosphatidylinositol 3-kinase (PI3K)-type domain profile. / Phosphoinositide 3-kinase, accessory (PIK) domain superfamily / Phosphoinositide 3-kinase family, accessory domain (PIK domain) / Phosphoinositide 3-kinase family, accessory domain (PIK domain) / Phosphoinositide 3-kinase, accessory (PIK) domain / Phosphatidylinositol kinase / PIK helical domain profile. / Phosphatidylinositol 3- and 4-kinases signature 1. / Phosphatidylinositol 3/4-kinase, conserved site / Phosphatidylinositol 3- and 4-kinases signature 2. / Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily / Phosphoinositide 3-kinase, catalytic domain / Phosphatidylinositol 3- and 4-kinase / Phosphatidylinositol 3- and 4-kinases catalytic domain profile. / Phosphatidylinositol 3-/4-kinase, catalytic domain / C2 domain superfamily / Armadillo-type fold / Ubiquitin-like domain superfamily / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 Chem-NQ5 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform類似検索 - 構成要素 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 2.4 Å |
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データ登録者 | Convery, M.A. / Rowland, P. / Henley, Z.A. / Barton, N. / Down, K. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2020 タイトル: Optimization of Orally Bioavailable PI3K delta Inhibitors and Identification of Vps34 as a Key Selectivity Target. 著者: Henley, Z.A. / Amour, A. / Barton, N. / Bantscheff, M. / Bergamini, G. / Bertrand, S.M. / Convery, M. / Down, K. / Dumpelfeld, B. / Edwards, C.D. / Grandi, P. / Gore, P.M. / Keeling, S. / ...著者: Henley, Z.A. / Amour, A. / Barton, N. / Bantscheff, M. / Bergamini, G. / Bertrand, S.M. / Convery, M. / Down, K. / Dumpelfeld, B. / Edwards, C.D. / Grandi, P. / Gore, P.M. / Keeling, S. / Livia, S. / Mallett, D. / Maxwell, A. / Price, M. / Rau, C. / Reinhard, F.B.M. / Rowedder, J. / Rowland, P. / Taylor, J.A. / Thomas, D.A. / Hessel, E.M. / Hamblin, J.N. |
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履歴 | 登録 | 2019年12月10日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2020年1月1日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年1月15日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.title / _citation.year / _citation_author.name |
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改定 1.2 | 2020年2月5日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.3 | 2020年3月4日 | Group: Data collection / カテゴリ: diffrn_source Item: _diffrn_source.pdbx_synchrotron_beamline / _diffrn_source.type |
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改定 1.4 | 2021年9月29日 | Group: Database references / Refinement description / Source and taxonomy カテゴリ: database_2 / entity_src_gen / software Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_name / _software.name |
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