- PDB-6of8: Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464Hi... -
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基本情報
登録情報
データベース: PDB / ID: 6of8
タイトル
Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CamKII-alpha hub domain
要素
Calcium/calmodulin-dependent protein kinase type II subunit alpha
キーワード
TRANSFERASE (転移酵素) / CaMKII hub domain / SIGNALING PROTEIN
機能・相同性
機能・相同性情報
peptidyl-threonine autophosphorylation / regulation of endocannabinoid signaling pathway / calcium- and calmodulin-dependent protein kinase complex / regulation of neuron migration / Ca2+/calmodulin-dependent protein kinase / regulation of neurotransmitter secretion / dendritic spine development / positive regulation of calcium ion transport / Trafficking of AMPA receptors / negative regulation of hydrolase activity ...peptidyl-threonine autophosphorylation / regulation of endocannabinoid signaling pathway / calcium- and calmodulin-dependent protein kinase complex / regulation of neuron migration / Ca2+/calmodulin-dependent protein kinase / regulation of neurotransmitter secretion / dendritic spine development / positive regulation of calcium ion transport / Trafficking of AMPA receptors / negative regulation of hydrolase activity / Assembly and cell surface presentation of NMDA receptors / calmodulin-dependent protein kinase activity / regulation of mitochondrial membrane permeability involved in apoptotic process / CaMK IV-mediated phosphorylation of CREB / Negative regulation of NMDA receptor-mediated neuronal transmission / positive regulation of cardiac muscle cell apoptotic process / Unblocking of NMDA receptors, glutamate binding and activation / regulation of neuronal synaptic plasticity / Phase 0 - rapid depolarisation / Ion transport by P-type ATPases / 長期増強 / Regulation of MECP2 expression and activity / HSF1-dependent transactivation / glutamate receptor binding / cellular response to interferon-beta / Ion homeostasis / Ras activation upon Ca2+ influx through NMDA receptor / response to ischemia / angiotensin-activated signaling pathway / G1/S transition of mitotic cell cycle / RAF activation / positive regulation of receptor signaling pathway via JAK-STAT / cellular response to type II interferon / Signaling by RAF1 mutants / endocytic vesicle membrane / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / calcium ion transport / Interferon gamma signaling / Signaling by BRAF and RAF1 fusions / Ca2+ pathway / positive regulation of NF-kappaB transcription factor activity / kinase activity / RAF/MAP kinase cascade / peptidyl-serine phosphorylation / 樹状突起スパイン / postsynaptic density / protein autophosphorylation / calmodulin binding / neuron projection / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / protein homodimerization activity / ミトコンドリア / 核質 / ATP binding / identical protein binding / metal ion binding / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能
Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / Nuclear Transport Factor 2; Chain: A, - #50 / NTF2-like domain superfamily / Nuclear Transport Factor 2; Chain: A, / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Roll ...Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / Nuclear Transport Factor 2; Chain: A, - #50 / NTF2-like domain superfamily / Nuclear Transport Factor 2; Chain: A, / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Roll / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Alpha Beta 類似検索 - ドメイン・相同性
: / Calcium/calmodulin-dependent protein kinase type II subunit alpha 類似検索 - 構成要素
#195 - 2016年3月 RAFタンパク質キナーゼ (RAF Protein Kinases) 類似性 (1)
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集合体
登録構造単位
F: Calcium/calmodulin-dependent protein kinase type II subunit alpha B: Calcium/calmodulin-dependent protein kinase type II subunit alpha C: Calcium/calmodulin-dependent protein kinase type II subunit alpha G: Calcium/calmodulin-dependent protein kinase type II subunit alpha E: Calcium/calmodulin-dependent protein kinase type II subunit alpha A: Calcium/calmodulin-dependent protein kinase type II subunit alpha D: Calcium/calmodulin-dependent protein kinase type II subunit alpha ヘテロ分子
F: Calcium/calmodulin-dependent protein kinase type II subunit alpha B: Calcium/calmodulin-dependent protein kinase type II subunit alpha C: Calcium/calmodulin-dependent protein kinase type II subunit alpha G: Calcium/calmodulin-dependent protein kinase type II subunit alpha E: Calcium/calmodulin-dependent protein kinase type II subunit alpha A: Calcium/calmodulin-dependent protein kinase type II subunit alpha D: Calcium/calmodulin-dependent protein kinase type II subunit alpha ヘテロ分子
F: Calcium/calmodulin-dependent protein kinase type II subunit alpha B: Calcium/calmodulin-dependent protein kinase type II subunit alpha C: Calcium/calmodulin-dependent protein kinase type II subunit alpha G: Calcium/calmodulin-dependent protein kinase type II subunit alpha E: Calcium/calmodulin-dependent protein kinase type II subunit alpha A: Calcium/calmodulin-dependent protein kinase type II subunit alpha D: Calcium/calmodulin-dependent protein kinase type II subunit alpha ヘテロ分子
温度: 293 K / 手法: 蒸気拡散法, シッティングドロップ法 詳細: 17 mg/mL mutant hub in 25 mM Tris, 150 mM KCl, 10% (v/v) glycerol, 2 mM DTT, 1 mM TCEP, pH 8.0 was mixed 1:1 with 235 mM K3Citrate, 15% (w/v) PEG 3350, pH 8.0
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データ収集
回折
平均測定温度: 100 K / Serial crystal experiment: N
放射光源
由来: シンクロトロン / サイト: ALS / ビームライン: 8.3.1 / 波長: 1.11583 Å