登録情報 データベース : PDB / ID : 6flc 構造の表示 ダウンロードとリンクタイトル 2C8 Fab bound to EDIII of DenV 2 要素Domain III of Dengue virus 2 Heavy chain of 2C8 Fab Light chain of 2C8 Fab 詳細キーワード VIRAL PROTEIN (ウイルスタンパク質) / Dengue virus / antibody (抗体) / macromolecular complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / フラビビリン / host cell mitochondrion / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / カプシド / : / nucleoside-triphosphate phosphatase / double-stranded RNA binding / protein complex oligomerization ... symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / フラビビリン / host cell mitochondrion / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / カプシド / : / nucleoside-triphosphate phosphatase / double-stranded RNA binding / protein complex oligomerization / monoatomic ion channel activity / mRNA (guanine-N7)-methyltransferase / methyltransferase cap1 / clathrin-dependent endocytosis of virus by host cell / mRNA (nucleoside-2'-O-)-methyltransferase activity / mRNA 5'-cap (guanine-N7-)-methyltransferase activity / RNA helicase activity / host cell endoplasmic reticulum membrane / host cell perinuclear region of cytoplasm / protein dimerization activity / ヘリカーゼ / induction by virus of host autophagy / RNA依存性RNAポリメラーゼ / viral RNA genome replication / RNA-dependent RNA polymerase activity / serine-type endopeptidase activity / fusion of virus membrane with host endosome membrane / エンベロープ (ウイルス) / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / host cell nucleus / virion attachment to host cell / virion membrane / structural molecule activity / ATP hydrolysis activity / タンパク質分解 / extracellular region / ATP binding / 生体膜 / metal ion binding 類似検索 - 分子機能 Immunoglobulin-like - #350 / : / Flavivirus envelope glycoprotein E, stem/anchor domain / RNA-directed RNA polymerase, thumb domain, Flavivirus / Flavivirus RNA-directed RNA polymerase, thumb domain / Flavivirus capsid protein C superfamily / : / Flavivirus non-structural protein NS2B / Flavivirus NS3 helicase, C-terminal helical domain / Genome polyprotein, Flavivirus ... Immunoglobulin-like - #350 / : / Flavivirus envelope glycoprotein E, stem/anchor domain / RNA-directed RNA polymerase, thumb domain, Flavivirus / Flavivirus RNA-directed RNA polymerase, thumb domain / Flavivirus capsid protein C superfamily / : / Flavivirus non-structural protein NS2B / Flavivirus NS3 helicase, C-terminal helical domain / Genome polyprotein, Flavivirus / Flavivirus non-structural protein NS4A / Flavivirus non-structural protein NS2B / Flavivirus capsid protein C / Flavivirus non-structural protein NS4B / mRNA cap 0/1 methyltransferase / Flavivirus capsid protein C / Flavivirus non-structural protein NS4B / Flavivirus non-structural protein NS4A / Flavivirus NS2B domain profile. / mRNA cap 0 and cap 1 methyltransferase (EC 2.1.1.56 and EC 2.1.1.57) domain profile. / Flavivirus non-structural protein NS2A / Flavivirus non-structural protein NS2A / Flavivirus NS3, petidase S7 / Peptidase S7, Flavivirus NS3 serine protease / Flavivirus NS3 protease (NS3pro) domain profile. / Envelope glycoprotein M, flavivirus / Flavivirus envelope glycoprotein M / RNA-directed RNA polymerase, flavivirus / Flavivirus RNA-directed RNA polymerase, fingers and palm domains / Flavivirus non-structural Protein NS1 / Flavivirus non-structural protein NS1 / Envelope glycoprotein M superfamily, flavivirus / Flavivirus polyprotein propeptide / Flavivirus polyprotein propeptide superfamily / Flavivirus polyprotein propeptide / Flaviviral glycoprotein E, central domain, subdomain 1 / Flaviviral glycoprotein E, central domain, subdomain 2 / Flavivirus envelope glycoprotein E, Stem/Anchor domain / Flavivirus glycoprotein E, immunoglobulin-like domain / Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily / Flavivirus glycoprotein, immunoglobulin-like domain / Flavivirus glycoprotein central and dimerisation domain / Flavivirus glycoprotein, central and dimerisation domains / Ribosomal RNA methyltransferase, FtsJ domain / FtsJ-like methyltransferase / Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily / Flavivirus glycoprotein, central and dimerisation domain superfamily / Flaviviral glycoprotein E, dimerisation domain / DEAD box, Flavivirus / Flavivirus DEAD domain / helicase superfamily c-terminal domain / Immunoglobulin E-set / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / S-adenosyl-L-methionine-dependent methyltransferase superfamily / 抗体 / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / DNA/RNA polymerase superfamily / Immunoglobulin-like / サンドイッチ / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta 類似検索 - ドメイン・相同性生物種 Mus musculus (ハツカネズミ) Dengue virus 2 (デング熱ウイルス)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2 Å 詳細データ登録者 Flanagan, A. / Renner, M. / Grimes, J.M. 資金援助 英国, 2件 詳細 詳細を隠す組織 認可番号 国 Wellcome Trust 204703/Z/16/Z 英国 Wellcome Trust 075491/Z/04 英国
引用ジャーナル : Nat. Immunol. / 年 : 2018タイトル : Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus.著者: Renner, M. / Flanagan, A. / Dejnirattisai, W. / Puttikhunt, C. / Kasinrerk, W. / Supasa, P. / Wongwiwat, W. / Chawansuntati, K. / Duangchinda, T. / Cowper, A. / Midgley, C.M. / Malasit, P. / ... 著者 : Renner, M. / Flanagan, A. / Dejnirattisai, W. / Puttikhunt, C. / Kasinrerk, W. / Supasa, P. / Wongwiwat, W. / Chawansuntati, K. / Duangchinda, T. / Cowper, A. / Midgley, C.M. / Malasit, P. / Huiskonen, J.T. / Mongkolsapaya, J. / Screaton, G.R. / Grimes, J.M. 履歴 登録 2018年1月25日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2018年10月24日 Provider : repository / タイプ : Initial release改定 1.1 2018年10月31日 Group : Data collection / Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last
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