登録情報 | データベース: PDB / ID: 5l3f |
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タイトル | LSD1-CoREST1 in complex with polymyxin B |
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要素 | - Lysine-specific histone demethylase 1A
- Polmyxin B
- REST corepressor 1RCOR1
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キーワード | OXIDOREDUCTASE (酸化還元酵素) / OXIDOREDUCTASE-REPRESSOR Complex / LSD1 / KDM1A / CoREST1 / chromatin (クロマチン) / epigenetic (エピジェネティクス) |
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機能・相同性 | 機能・相同性情報
positive regulation of megakaryocyte differentiation / guanine metabolic process / protein demethylation / [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase / FAD-dependent H3K4me/H3K4me3 demethylase activity / demethylase activity / regulation of DNA methylation-dependent heterochromatin formation / telomeric repeat-containing RNA binding / histone H3K4 demethylase activity / muscle cell development ...positive regulation of megakaryocyte differentiation / guanine metabolic process / protein demethylation / [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase / FAD-dependent H3K4me/H3K4me3 demethylase activity / demethylase activity / regulation of DNA methylation-dependent heterochromatin formation / telomeric repeat-containing RNA binding / histone H3K4 demethylase activity / muscle cell development / positive regulation of neural precursor cell proliferation / neuron maturation / regulation of androgen receptor signaling pathway / MRF binding / DNA repair complex / DNA repair-dependent chromatin remodeling / nuclear androgen receptor binding / regulation of double-strand break repair via homologous recombination / positive regulation of neuroblast proliferation / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / positive regulation of stem cell proliferation / negative regulation of DNA binding / histone H3K9 demethylase activity / negative regulation of DNA damage response, signal transduction by p53 class mediator / histone deacetylase complex / positive regulation of cell size / histone demethylase activity / response to fungicide / cellular response to cAMP / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / transcription repressor complex / 赤血球形成 / nuclear receptor coactivator activity / negative regulation of protein binding / Regulation of PTEN gene transcription / positive regulation of protein ubiquitination / promoter-specific chromatin binding / HDACs deacetylate histones / cellular response to gamma radiation / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / HDMs demethylate histones / negative regulation of DNA-binding transcription factor activity / cerebral cortex development / positive regulation of neuron projection development / transcription corepressor activity / cellular response to UV / regulation of protein localization / p53 binding / flavin adenine dinucleotide binding / positive regulation of cold-induced thermogenesis / chromatin organization / Factors involved in megakaryocyte development and platelet production / DNA-binding transcription factor binding / Estrogen-dependent gene expression / transcription regulator complex / RNA polymerase II-specific DNA-binding transcription factor binding / Potential therapeutics for SARS / chromosome, telomeric region / transcription coactivator activity / oxidoreductase activity / negative regulation of gene expression / negative regulation of DNA-templated transcription / chromatin binding / クロマチン / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / enzyme binding / positive regulation of transcription by RNA polymerase II / protein-containing complex / 核質 / identical protein binding / 細胞核類似検索 - 分子機能 Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1880 / : / Helical region in REST corepressor / ELM2 domain / ELM2 domain / ELM2 domain profile. / ELM2 / Histone lysine-specific demethylase / SWIRM domain / SWIRM domain ...Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1880 / : / Helical region in REST corepressor / ELM2 domain / ELM2 domain / ELM2 domain profile. / ELM2 / Histone lysine-specific demethylase / SWIRM domain / SWIRM domain / SWIRM domain profile. / ATP synthase, gamma subunit, helix hairpin domain / SANT domain profile. / SANT domain / Amine oxidase / Flavin containing amine oxidoreductase / Myb-like DNA-binding domain / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Homeobox-like domain superfamily / FAD/NAD(P)-binding domain superfamily / Helix Hairpins / Arc Repressor Mutant, subunit A / Winged helix-like DNA-binding domain superfamily / Up-down Bundle / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 フラビンアデニンジヌクレオチド / Lysine-specific histone demethylase 1A / REST corepressor 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) Paenibacillus polymyxa (パエニバシラス・ポリミキサ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.5 Å |
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データ登録者 | Speranzini, V. / Rotili, D. / Ciossani, G. / Pilotto, S. / Forgione, M. / Lucidi, A. / Forneris, F. / Velankar, S. / Mai, A. / Mattevi, A. |
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資金援助 | イタリア, 米国, 11件 組織 | 認可番号 | 国 |
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AIRC | IG-15208 | イタリア | MIUR | Progetto Bandiera Epigenomica - EPIGEN | イタリア | | RF-2010-2318330 | イタリア | | Sapienza Award Project 2014 | イタリア | | IIT-Sapienza Project | イタリア | AIRC-Fondazione Cariplo | TRIDEO Id. 17515 | イタリア | MIUR | PRIN 2012CTAYSY | イタリア | EU | FP7 Projects BLUEPRINT/282510 | | | A-PARADDISE/602080 | | Giovanni Armenise-Harvard foundation | Career development award 2013 | 米国 | MIUR | Programma Giovani Ricercatori Rita Levi-Montalcini 2013 | イタリア |
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引用 | ジャーナル: Sci Adv / 年: 2016 タイトル: Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features. 著者: Speranzini, V. / Rotili, D. / Ciossani, G. / Pilotto, S. / Marrocco, B. / Forgione, M. / Lucidi, A. / Forneris, F. / Mehdipour, P. / Velankar, S. / Mai, A. / Mattevi, A. |
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履歴 | 登録 | 2016年4月10日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2016年9月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年10月5日 | Group: Database references |
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改定 1.2 | 2024年1月10日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag |
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