登録情報 データベース : PDB / ID : 5a3w 構造の表示 ダウンロードとリンクタイトル Crystal structure of human PLU-1 (JARID1B) in complex with Pyridine-2, 6-dicarboxylic Acid (PDCA) 要素LYSINE-SPECIFIC DEMETHYLASE 5B 詳細 キーワード OXIDOREDUCTASE (酸化還元酵素) / LYSINE-SPECIFIC DEMETHYLASE 5B機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of estradiol secretion / mammary duct terminal end bud growth / uterus morphogenesis / TFAP2 (AP-2) family regulates transcription of cell cycle factors / positive regulation of mammary gland epithelial cell proliferation / [histone H3]-trimethyl-L-lysine4 demethylase / histone H3K4me/H3K4me2/H3K4me3 demethylase activity / lens fiber cell differentiation / histone H3K4 demethylase activity / cellular response to fibroblast growth factor stimulus ... regulation of estradiol secretion / mammary duct terminal end bud growth / uterus morphogenesis / TFAP2 (AP-2) family regulates transcription of cell cycle factors / positive regulation of mammary gland epithelial cell proliferation / [histone H3]-trimethyl-L-lysine4 demethylase / histone H3K4me/H3K4me2/H3K4me3 demethylase activity / lens fiber cell differentiation / histone H3K4 demethylase activity / cellular response to fibroblast growth factor stimulus / branching involved in mammary gland duct morphogenesis / single fertilization / histone demethylase activity / response to fungicide / cellular response to leukemia inhibitory factor / post-embryonic development / Chromatin modifications during the maternal to zygotic transition (MZT) / HDMs demethylate histones / transcription corepressor activity / rhythmic process / sequence-specific double-stranded DNA binding / histone binding / nucleic acid binding / クロマチンリモデリング / negative regulation of DNA-templated transcription / クロマチン / positive regulation of gene expression / regulation of DNA-templated transcription / DNA binding / zinc ion binding / 核質 / 細胞核 / 細胞質基質 類似検索 - 分子機能 : / : / : / : / Lysine-specific demethylase 5, C-terminal helical domain / Lysine-specific demethylase-like domain / PLU-1-like protein / Zinc finger, C5HC2-type / C5HC2 zinc finger / ARID/BRIGHT DNA binding domain ... : / : / : / : / Lysine-specific demethylase 5, C-terminal helical domain / Lysine-specific demethylase-like domain / PLU-1-like protein / Zinc finger, C5HC2-type / C5HC2 zinc finger / ARID/BRIGHT DNA binding domain / ARID DNA-binding domain / ARID DNA-binding domain superfamily / ARID/BRIGHT DNA binding domain / ARID domain profile. / BRIGHT, ARID (A/T-rich interaction domain) domain / JmjN domain / jmjN domain / JmjN domain profile. / Small domain found in the jumonji family of transcription factors / Cupin / JmjC domain, hydroxylase / A domain family that is part of the cupin metalloenzyme superfamily. / JmjC domain / JmjC domain profile. / Zinc finger, PHD-type, conserved site / PHD-finger / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Zinc finger, FYVE/PHD-type / Zinc finger, RING/FYVE/PHD-type / Jelly Rolls / サンドイッチ / Mainly Beta 類似検索 - ドメイン・相同性 : / PYRIDINE-2,4-DICARBOXYLIC ACID / リン酸塩 / Lysine-specific demethylase 5B 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2 Å 詳細データ登録者 Srikannathasan, V. / Johansson, C. / Gileadi, C. / Kopec, J. / Strain-Damerell, C. / Kupinska, K. / Burgess-Brown, N.A. / von Delft, F. / Arrowsmith, C.H. / Bountra, C. ...Srikannathasan, V. / Johansson, C. / Gileadi, C. / Kopec, J. / Strain-Damerell, C. / Kupinska, K. / Burgess-Brown, N.A. / von Delft, F. / Arrowsmith, C.H. / Bountra, C. / Edwards, A.M. / Oppermann, U. 引用ジャーナル : Nat.Chem.Biol. / 年 : 2016タイトル : Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.著者: Johansson, C. / Velupillai, S. / Tumber, A. / Szykowska, A. / Hookway, E.S. / Nowak, R.P. / Strain-Damerell, C. / Gileadi, C. / Philpott, M. / Burgess-Brown, N. / Wu, N. / Kopec, J. / Nuzzi, ... 著者 : Johansson, C. / Velupillai, S. / Tumber, A. / Szykowska, A. / Hookway, E.S. / Nowak, R.P. / Strain-Damerell, C. / Gileadi, C. / Philpott, M. / Burgess-Brown, N. / Wu, N. / Kopec, J. / Nuzzi, A. / Steuber, H. / Egner, U. / Badock, V. / Munro, S. / Lathangue, N.B. / Westaway, S. / Brown, J. / Athanasou, N. / Prinjha, R. / Brennan, P.E. / Oppermann, U. 履歴 登録 2015年6月3日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2015年6月17日 Provider : repository / タイプ : Initial release改定 1.1 2016年5月25日 Group : Database references改定 1.2 2016年6月1日 Group : Database references改定 1.3 2016年6月29日 Group : Database references改定 1.4 2018年1月24日 Group : Structure summary / カテゴリ : audit_author / Item : _audit_author.name
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