登録情報 | データベース: PDB / ID: 4rwp |
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タイトル | Crystal structure of porcine OAS1 in complex with dsRNA |
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要素 | - 2'-5'-oligoadenylate synthase 1
- RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3')
- RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3')
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キーワード | TRANSFERASE/RNA / Interferon-induced / dsRNA-activated / TRANSFERASE-RNA complex |
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機能・相同性 | 機能・相同性情報
negative regulation of transformation of host cell by virus / 2'-5' oligoadenylate synthase / 2'-5'-oligoadenylate synthetase activity / regulation of ribonuclease activity / negative regulation of viral genome replication / double-stranded RNA binding / defense response to virus / 自然免疫系 / 小胞体 / ミトコンドリア ...negative regulation of transformation of host cell by virus / 2'-5' oligoadenylate synthase / 2'-5'-oligoadenylate synthetase activity / regulation of ribonuclease activity / negative regulation of viral genome replication / double-stranded RNA binding / defense response to virus / 自然免疫系 / 小胞体 / ミトコンドリア / extracellular region / 核質 / ATP binding / 生体膜 / metal ion binding / 細胞質基質 / 細胞質類似検索 - 分子機能 2'-5'-oligoadenylate synthetase 1, domain 2 / 2-5-oligoadenylate synthetase, N-terminal conserved site / 2'-5'-oligoadenylate synthases signature 1. / 2-5-oligoadenylate synthetase, C-terminal conserved site / 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal / 2'-5'-oligoadenylate synthases signature 2. / 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus / 2'-5'-oligoadenylate synthase N-terminal region profile. / 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain / Poly(a)-polymerase, middle domain ...2'-5'-oligoadenylate synthetase 1, domain 2 / 2-5-oligoadenylate synthetase, N-terminal conserved site / 2'-5'-oligoadenylate synthases signature 1. / 2-5-oligoadenylate synthetase, C-terminal conserved site / 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal / 2'-5'-oligoadenylate synthases signature 2. / 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus / 2'-5'-oligoadenylate synthase N-terminal region profile. / 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain / Poly(a)-polymerase, middle domain / Polymerase, nucleotidyl transferase domain / Nucleotidyltransferase domain / Beta Polymerase, domain 2 / Beta Polymerase; domain 2 / Nucleotidyltransferase superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 リボ核酸 / RNA (> 10) / 2'-5'-oligoadenylate synthase 1類似検索 - 構成要素 |
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生物種 | Sus scrofa (ブタ) synthetic construct (人工物) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.25 Å |
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データ登録者 | Lohoefener, J. / Steinke, N. / Kay-Fedorov, P. / Baruch, P. / Nikulin, A. / Tishchenko, S. / Manstein, D.J. / Fedorov, R. |
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引用 | ジャーナル: Structure / 年: 2015 タイトル: The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity. 著者: Lohofener, J. / Steinke, N. / Kay-Fedorov, P. / Baruch, P. / Nikulin, A. / Tishchenko, S. / Manstein, D.J. / Fedorov, R. |
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履歴 | 登録 | 2014年12月5日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年5月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年2月28日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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