登録情報 データベース : PDB / ID : 3ex7 構造の表示 ダウンロードとリンクタイトル The crystal structure of EJC in its transition state 要素Eukaryotic initiation factor 4A-III Protein CASC3 Protein mago nashi homolog RNA (5'-R(*UP*UP*UP*UP*UP*U)-3')RNA-binding protein 8A 詳細キーワード hydrolase/RNA binding protein/RNA / PROTEIN-RNA COMPLEX / mRNA processing (転写後修飾) / mRNA splicing / mRNA transport / Nonsense-mediated mRNA decay (ナンセンス変異依存mRNA分解機構) / Nucleus (Nucleus) / RNA-binding / Spliceosome (スプライセオソーム) / Transport / Alternative splicing (選択的スプライシング) / Cytoplasm (細胞質) / Phosphoprotein / Acetylation (アセチル化) / ATP-binding / Helicase (ヘリカーゼ) / Hydrolase (加水分解酵素) / Nucleotide-binding / rRNA processing / Coiled coil (コイルドコイル) / hydrolase-RNA binding protein-RNA COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
exon-exon junction subcomplex mago-y14 / negative regulation of selenocysteine incorporation / regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / cellular response to selenite ion / selenocysteine insertion sequence binding / exon-exon junction complex / intracellular mRNA localization / regulation of translation at postsynapse, modulating synaptic transmission / negative regulation of excitatory postsynaptic potential / Z-decay: degradation of maternal mRNAs by zygotically expressed factors ... exon-exon junction subcomplex mago-y14 / negative regulation of selenocysteine incorporation / regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / cellular response to selenite ion / selenocysteine insertion sequence binding / exon-exon junction complex / intracellular mRNA localization / regulation of translation at postsynapse, modulating synaptic transmission / negative regulation of excitatory postsynaptic potential / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / regulation of mRNA processing / Deadenylation of mRNA / U2-type catalytic step 1 spliceosome / poly(A) binding / M-decay: degradation of maternal mRNAs by maternally stored factors / RNA stem-loop binding / mRNA 3'-end processing / embryonic cranial skeleton morphogenesis / Transport of Mature mRNA derived from an Intron-Containing Transcript / RNA Polymerase II Transcription Termination / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / exploration behavior / regulation of alternative mRNA splicing, via spliceosome / 学習 / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / ribonucleoprotein complex binding / mRNA export from nucleus / cellular response to brain-derived neurotrophic factor stimulus / catalytic step 2 spliceosome / mRNA Splicing - Major Pathway / RNA splicing / positive regulation of translation / response to organic cyclic compound / ISG15 antiviral mechanism / mRNA splicing, via spliceosome / rRNA processing / Regulation of expression of SLITs and ROBOs / cytoplasmic stress granule / regulation of translation / postsynapse / 核膜 / negative regulation of translation / RNA helicase activity / ヘリカーゼ / nuclear speck / mRNA binding / 樹状突起 / neuronal cell body / glutamatergic synapse / ubiquitin protein ligase binding / 核小体 / perinuclear region of cytoplasm / enzyme binding / ATP hydrolysis activity / RNA binding / 核質 / ATP binding / 生体膜 / identical protein binding / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 Mago nashi protein / Mago nashi / CASC3/Barentsz eIF4AIII binding / CASC3/Barentsz eIF4AIII binding / Btz domain / Mago nashi protein / RNA-binding motif protein 8 / RBM8, RNA recognition motif / Mago nashi superfamily / Mago nashi protein ... Mago nashi protein / Mago nashi / CASC3/Barentsz eIF4AIII binding / CASC3/Barentsz eIF4AIII binding / Btz domain / Mago nashi protein / RNA-binding motif protein 8 / RBM8, RNA recognition motif / Mago nashi superfamily / Mago nashi protein / DEAD-box subfamily ATP-dependent helicases signature. / ATP-dependent RNA helicase DEAD-box, conserved site / RNA helicase, DEAD-box type, Q motif / DEAD-box RNA helicase Q motif profile. / RRM (RNA recognition motif) domain / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain / RNA認識モチーフ / RNA認識モチーフ / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / Helicase conserved C-terminal domain / RNA-binding domain superfamily / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / Nucleotide-binding alpha-beta plait domain superfamily / P-loop containing nucleotide triphosphate hydrolases / Alpha-Beta Plaits / P-loop containing nucleoside triphosphate hydrolase / ロスマンフォールド / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 ADENOSINE-5'-DIPHOSPHATE / フッ化アルミニウム / リボ核酸 / Protein CASC3 / Eukaryotic initiation factor 4A-III / Protein mago nashi homolog / RNA-binding protein 8A 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.301 Å 詳細データ登録者 Andersen, G.R. / Nielsen, K.H. 引用ジャーナル : Rna / 年 : 2009タイトル : Mechanism of ATP turnover inhibition in the EJC著者 : Nielsen, K.H. / Chamieh, H. / Andersen, C.B. / Fredslund, F. / Hamborg, K. / Le Hir, H. / Andersen, G.R. 履歴 登録 2008年10月16日 登録サイト : RCSB / 処理サイト : PDBJ改定 1.0 2008年12月9日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2023年11月1日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / software / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _software.name / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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