登録情報 | データベース: PDB / ID: 1y3a |
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タイトル | Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange |
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要素 | - Guanine nucleotide-binding protein G(i), alpha-1 subunit
- KB752 peptide
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キーワード | SIGNALING PROTEIN / PROTEIN-PEPTIDE COMPLEX |
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機能・相同性 | 機能・相同性情報
Adenylate cyclase inhibitory pathway / positive regulation of protein localization to cell cortex / regulation of cAMP-mediated signaling / D2 dopamine receptor binding / G protein-coupled serotonin receptor binding / regulation of mitotic spindle organization / cellular response to forskolin / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / Regulation of insulin secretion / G protein-coupled receptor binding ...Adenylate cyclase inhibitory pathway / positive regulation of protein localization to cell cortex / regulation of cAMP-mediated signaling / D2 dopamine receptor binding / G protein-coupled serotonin receptor binding / regulation of mitotic spindle organization / cellular response to forskolin / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / Regulation of insulin secretion / G protein-coupled receptor binding / G-protein beta/gamma-subunit complex binding / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / ADP signalling through P2Y purinoceptor 12 / response to peptide hormone / Adrenaline,noradrenaline inhibits insulin secretion / G alpha (z) signalling events / ADORA2B mediated anti-inflammatory cytokines production / GPER1 signaling / GDP binding / heterotrimeric G-protein complex / 細胞皮質 / midbody / G alpha (i) signalling events / G alpha (s) signalling events / Extra-nuclear estrogen signaling / 細胞周期 / G protein-coupled receptor signaling pathway / 細胞分裂 / lysosomal membrane / GTPase activity / 中心体 / GTP binding / 核小体 / magnesium ion binding / extracellular exosome / 核質 / 細胞膜 / 細胞質類似検索 - 分子機能 GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / G-protein alpha subunit, group I / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase ...GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / G-protein alpha subunit, group I / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / ロスマンフォールド / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 GUANOSINE-5'-DIPHOSPHATE / Guanine nucleotide-binding protein G(i) subunit alpha-1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.5 Å |
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データ登録者 | Johnston, C.A. / Willard, F.S. / Jezyk, M.R. / Fredericks, Z. / Bodor, E.T. / Jones, M.B. / Blaesius, R. / Harden, T.K. / Sondek, J. / Watts, V.J. ...Johnston, C.A. / Willard, F.S. / Jezyk, M.R. / Fredericks, Z. / Bodor, E.T. / Jones, M.B. / Blaesius, R. / Harden, T.K. / Sondek, J. / Watts, V.J. / Ramer, J.K. / Siderovski, D.P. |
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引用 | ジャーナル: Structure / 年: 2005 タイトル: Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange 著者: Johnston, C.A. / Willard, F.S. / Jezyk, M.R. / Fredericks, Z. / Bodor, E.T. / Jones, M.B. / Blaesius, R. / Watts, V.J. / Harden, T.K. / Sondek, J. / Ramer, J.K. / Siderovski, D.P. |
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履歴 | 登録 | 2004年11月24日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2005年7月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月30日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2019年3月27日 | Group: Data collection / Derived calculations カテゴリ: pdbx_struct_assembly / pdbx_struct_assembly_gen ...pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_assembly_prop / struct_biol Item: _pdbx_struct_assembly.details / _pdbx_struct_assembly.method_details ..._pdbx_struct_assembly.details / _pdbx_struct_assembly.method_details / _pdbx_struct_assembly.oligomeric_count / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_assembly_gen.asym_id_list |
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改定 1.4 | 2023年8月23日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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Remark 999 | SEQUENCE THERE IS NO SUITABLE SEQUENCE DATABASE REFERENCE FOR CHAINS E-H AT THE TIME OF PROCESSING. |
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