+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 1mek | ||||||
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タイトル | HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES | ||||||
要素 | PROTEIN DISULFIDE ISOMERASEプロテインジスルフィドイソメラーゼ | ||||||
キーワード | ELECTRON TRANSPORT (電子伝達系) / REDOX-ACTIVE CENTER / ISOMERASE (異性化酵素) / ENDOPLASMIC RETICULUM (小胞体) | ||||||
機能・相同性 | 機能・相同性情報 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / procollagen-proline 4-dioxygenase complex / VLDL assembly / insulin processing / procollagen-proline 4-dioxygenase activity / interleukin-23-mediated signaling pathway / LDL remodeling / thiol oxidase activity / プロテインジスルフィドイソメラーゼ / peptidyl-proline hydroxylation to 4-hydroxy-L-proline ...regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / procollagen-proline 4-dioxygenase complex / VLDL assembly / insulin processing / procollagen-proline 4-dioxygenase activity / interleukin-23-mediated signaling pathway / LDL remodeling / thiol oxidase activity / プロテインジスルフィドイソメラーゼ / peptidyl-proline hydroxylation to 4-hydroxy-L-proline / endoplasmic reticulum chaperone complex / protein folding in endoplasmic reticulum / Collagen biosynthesis and modifying enzymes / Chylomicron assembly / Interleukin-23 signaling / interleukin-12-mediated signaling pathway / cellular response to interleukin-7 / Interleukin-12 signaling / protein disulfide isomerase activity / Insulin processing / Detoxification of Reactive Oxygen Species / protein-disulfide reductase activity / positive regulation of cell adhesion / endoplasmic reticulum-Golgi intermediate compartment / endoplasmic reticulum to Golgi vesicle-mediated transport / positive regulation of substrate adhesion-dependent cell spreading / response to endoplasmic reticulum stress / Hedgehog ligand biogenesis / Post-translational protein phosphorylation / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / メラノソーム / integrin binding / フォールディング / lamellipodium / actin binding / cellular response to hypoxia / positive regulation of viral entry into host cell / 細胞骨格 / protein heterodimerization activity / external side of plasma membrane / 小胞体 / focal adhesion / enzyme binding / 小胞体 / protein-containing complex / RNA binding / extracellular exosome / extracellular region / 細胞質基質 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | 溶液NMR | ||||||
データ登録者 | Kemmink, J. / Darby, N.J. / Dijkstra, K. / Nilges, M. / Creighton, T.E. | ||||||
引用 | ジャーナル: Biochemistry / 年: 1996 タイトル: Structure determination of the N-terminal thioredoxin-like domain of protein disulfide isomerase using multidimensional heteronuclear 13C/15N NMR spectroscopy. 著者: Kemmink, J. / Darby, N.J. / Dijkstra, K. / Nilges, M. / Creighton, T.E. #1: ジャーナル: Protein Sci. / 年: 1995 タイトル: Nuclear Magnetic Resonance Characterization of the N-Terminal Thioredoxin-Like Domain of Protein Disulfide Isomerase 著者: Kemmink, J. / Darby, N.J. / Dijkstra, K. / Scheek, R.M. / Creighton, T.E. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 1mek.cif.gz | 1.5 MB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb1mek.ent.gz | 1.4 MB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 1mek.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/me/1mek ftp://data.pdbj.org/pub/pdb/validation_reports/me/1mek | HTTPS FTP |
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-関連構造データ
-リンク
-集合体
登録構造単位 |
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1 |
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NMR アンサンブル |
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-要素
#1: タンパク質 | 分子量: 13276.909 Da / 分子数: 1 / 断片: PROLYL 4-HYDROXYLASE BETA SUBUNIT / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / プラスミド: PET-12 / 発現宿主: Escherichia coli (大腸菌) 参照: UniProt: P07237, プロテインジスルフィドイソメラーゼ |
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-実験情報
-実験
実験 | 手法: 溶液NMR |
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-試料調製
結晶化 | *PLUS 手法: その他 / 詳細: NMR |
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-解析
ソフトウェア |
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NMR software | 名称: X-PLOR / バージョン: 3.1 / 開発者: BRUNGER / 分類: 精密化 | ||||||||||||
精密化 | ソフトェア番号: 1 詳細: STRUCTURES WERE DETERMINED USING A HYBRID DISTANCE GEOMETRY/SIMULATED ANNEALING APPROACH (M. NILGES, G.M. CLORE, A.M. GRONENBORN, FEBS LETT. 229, 317, 1988). THE STRUCTURES ARE BASED ON 1270 ...詳細: STRUCTURES WERE DETERMINED USING A HYBRID DISTANCE GEOMETRY/SIMULATED ANNEALING APPROACH (M. NILGES, G.M. CLORE, A.M. GRONENBORN, FEBS LETT. 229, 317, 1988). THE STRUCTURES ARE BASED ON 1270 INTERPROTON DISTANCE RESTRAINTS DERIVED FROM NOE MEASUREMENTS; 34 HYDROGEN BOND DISTANCE RESTRAINTS DERIVED FROM 17 SLOWLY EXCHANGING AMIDE PROTONS AND OBSERVED NOE PATTERNS; AND 5 DISTANCE RESTRAINTS WHICH DEFINE THE DISULFIDE BOND BETWEEN CYS 36 AND CYS 39. | ||||||||||||
NMRアンサンブル | 登録したコンフォーマーの数: 40 |