+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 1jfw | |||||||||
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タイトル | HOMONUCLEAR AND HETERONUCLEAR 1H-13C NUCLEAR MAGNETIC RESONANCE ASSIGNMENT AND STRUCTURAL CHARACTERIZATION OF A HIV-1 TAT PROTEIN | |||||||||
要素 | TAT PROTEIN | |||||||||
キーワード | VIRAL PROTEIN (ウイルスタンパク質) / TAT / HIV-1 / HETERONUCLEAR / DRUG DESIGN (医薬品設計) | |||||||||
機能・相同性 | 機能・相同性情報 viral gene expression / trans-activation response element binding / protein serine/threonine phosphatase inhibitor activity / regulatory region RNA binding / negative regulation of cellular respiration / positive regulation of viral transcription / modulation by virus of host chromatin organization / symbiont-mediated suppression of host translation initiation / host cell nucleolus / membrane hyperpolarization ...viral gene expression / trans-activation response element binding / protein serine/threonine phosphatase inhibitor activity / regulatory region RNA binding / negative regulation of cellular respiration / positive regulation of viral transcription / modulation by virus of host chromatin organization / symbiont-mediated suppression of host translation initiation / host cell nucleolus / membrane hyperpolarization / actinin binding / negative regulation of peptidyl-threonine phosphorylation / RNA-binding transcription regulator activity / cyclin binding / positive regulation of transcription elongation by RNA polymerase II / positive regulation of protein localization to nucleus / positive regulation of NF-kappaB transcription factor activity / host cell cytoplasm / protein domain specific binding / DNA-templated transcription / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / extracellular region / metal ion binding 類似検索 - 分子機能 | |||||||||
手法 | 溶液NMR / SIMULATED ANNEALING, RANDOM LOOP RESEARCH VALIDATED WITH NOE BACK-CALCULATION ENERGY MINIMIZATION, MOLECULAR DYNAMIC | |||||||||
データ登録者 | Peloponese, J.M. / Gregoire, C. / Opi, S. / Esquieu, D. | |||||||||
引用 | ジャーナル: C.R.Acad.Sci.III / 年: 2000 タイトル: 1H-13C nuclear magnetic resonance assignment and structural characterization of HIV-1 Tat protein. 著者: Peloponese Jr., J.M. / Gregoire, C. / Opi, S. / Esquieu, D. / Sturgis, J. / Lebrun, E. / Meurs, E. / Collette, Y. / Olive, D. / Aubertin, A.M. / Witvrow, M. / Pannecouque, C. / De Clercq, E. ...著者: Peloponese Jr., J.M. / Gregoire, C. / Opi, S. / Esquieu, D. / Sturgis, J. / Lebrun, E. / Meurs, E. / Collette, Y. / Olive, D. / Aubertin, A.M. / Witvrow, M. / Pannecouque, C. / De Clercq, E. / Bailly, C. / Lebreton, J. / Loret, E.P. | |||||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 1jfw.cif.gz | 296.9 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb1jfw.ent.gz | 254.5 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 1jfw.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/jf/1jfw ftp://data.pdbj.org/pub/pdb/validation_reports/jf/1jfw | HTTPS FTP |
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-関連構造データ
-リンク
-集合体
登録構造単位 |
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1 |
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NMR アンサンブル |
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-要素
#1: タンパク質 | 分子量: 9789.319 Da / 分子数: 1 / 由来タイプ: 合成 詳細: THIS PEPTIDE WAS SYNTHESIZED (SOLID PHASE SYNTHESIS). THE SEQUENCE OF THIS PEPTIDE OCCURS NATURALLY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 参照: UniProt: P04610 |
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-実験情報
-実験
実験 | 手法: 溶液NMR | ||||||||||||||||
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NMR実験 |
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-試料調製
詳細 | 内容: SPECIFIC 13C LABELLING OF GLYCINE 15,44,48,61,79,83 |
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試料状態 | pH: 4.50 / 温度: 298.00 K |
結晶化 | *PLUS 手法: その他 / 詳細: NMR |
-NMR測定
NMRスペクトロメーター | タイプ: Bruker DRX / 製造業者: Bruker / モデル: DRX / 磁場強度: 500 MHz |
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-解析
NMR software |
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精密化 | 手法: SIMULATED ANNEALING, RANDOM LOOP RESEARCH VALIDATED WITH NOE BACK-CALCULATION ENERGY MINIMIZATION, MOLECULAR DYNAMIC ソフトェア番号: 1 詳細: THE STRUCTURES ARE BASED ON A TOTAL OF 915 RESTRAINTS AND 272 ARE LONG-RANGE NOES. | ||||||||||||||||||||||||||||||||
NMRアンサンブル | コンフォーマー選択の基準: BACK CALCULATED DATA AGREE WITH EXPERIMEN TAL NOESY SPECTRUM, STRUCTURES WITH ACCEPTABLE COVALENT GEOMETRY,STRUCTURES WITH FAVORABLE NON-BOND ENERGY,STRUCTURES ...コンフォーマー選択の基準: BACK CALCULATED DATA AGREE WITH EXPERIMEN TAL NOESY SPECTRUM, STRUCTURES WITH ACCEPTABLE COVALENT GEOMETRY,STRUCTURES WITH FAVORABLE NON-BOND ENERGY,STRUCTURES WITH THE LEAST RESTRAINT VIOLATIONS,STRUCTURES WITH THE LOWEST ENERGY, TARGET FUNCTION 計算したコンフォーマーの数: 100 / 登録したコンフォーマーの数: 11 |