登録情報 データベース : PDB / ID : 1b50 構造の表示 ダウンロードとリンクタイトル NMR STRUCTURE OF HUMAN MIP-1A D26A, 10 STRUCTURES 要素MIP-1A 詳細 キーワード CHEMOKINE / CYTOKINE / CHEMOTAXIS機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
granulocyte chemotaxis / lymphocyte chemotaxis / CCR1 chemokine receptor binding / positive regulation of microglial cell migration / positive regulation of natural killer cell chemotaxis / signaling / regulation of behavior / astrocyte cell migration / CCR5 chemokine receptor binding / eosinophil degranulation ... granulocyte chemotaxis / lymphocyte chemotaxis / CCR1 chemokine receptor binding / positive regulation of microglial cell migration / positive regulation of natural killer cell chemotaxis / signaling / regulation of behavior / astrocyte cell migration / CCR5 chemokine receptor binding / eosinophil degranulation / regulation of sensory perception of pain / negative regulation of bone mineralization / negative regulation by host of viral transcription / CCR chemokine receptor binding / positive regulation of microglial cell activation / cell activation / T cell chemotaxis / positive regulation of calcium ion transport / eosinophil chemotaxis / response to cholesterol / chemokine-mediated signaling pathway / Chemokine receptors bind chemokines / release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / chemokine activity / phospholipase activator activity / macrophage chemotaxis / positive regulation of calcium ion import / chemoattractant activity / negative regulation of osteoclast differentiation / exocytosis / monocyte chemotaxis / Interleukin-10 signaling / cellular response to interleukin-1 / cytoskeleton organization / positive regulation of calcium-mediated signaling / neutrophil chemotaxis / positive regulation of interleukin-1 beta production / calcium-mediated signaling / response to toxic substance / cellular response to type II interferon / intracellular calcium ion homeostasis / positive regulation of inflammatory response / osteoblast differentiation / chemotaxis / calcium ion transport / positive regulation of neuron apoptotic process / MAPK cascade / positive regulation of tumor necrosis factor production / antimicrobial humoral immune response mediated by antimicrobial peptide / cell-cell signaling / cellular response to tumor necrosis factor / kinase activity / regulation of cell shape / positive regulation of ERK1 and ERK2 cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of cell migration / protein kinase activity / inflammatory response / negative regulation of gene expression / positive regulation of gene expression / extracellular space / extracellular region / identical protein binding / cytoplasm / cytosol 類似検索 - 分子機能 CC chemokine, conserved site / Small cytokines (intercrine/chemokine) C-C subfamily signature. / Chemokine beta/gamma/delta / Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). / Chemokine interleukin-8-like domain / Chemokine interleukin-8-like superfamily / Small cytokines (intecrine/chemokine), interleukin-8 like / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #40 / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 溶液NMR / SIMULATED ANNEALING STARTING FROM RANDOM ATOM POSITIONS 詳細データ登録者 Waltho, J.P. / Higgins, L.D. / Craven, C.J. / Tan, P. / Dudgeon, T. 引用ジャーナル : J.Biol.Chem. / 年 : 1999タイトル: Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active ... タイトル : Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants.著者: Czaplewski, L.G. / McKeating, J. / Craven, C.J. / Higgins, L.D. / Appay, V. / Brown, A. / Dudgeon, T. / Howard, L.A. / Meyers, T. / Owen, J. / Palan, S.R. / Tan, P. / Wilson, G. / Woods, N.R. ... 著者 : Czaplewski, L.G. / McKeating, J. / Craven, C.J. / Higgins, L.D. / Appay, V. / Brown, A. / Dudgeon, T. / Howard, L.A. / Meyers, T. / Owen, J. / Palan, S.R. / Tan, P. / Wilson, G. / Woods, N.R. / Heyworth, C.M. / Lord, B.I. / Brotherton, D. / Christison, R. / Craig, S. / Cribbes, S. / Edwards, R.M. / Evans, S.J. / Gilbert, R. / Morgan, P. / Randle, E. / Schofield, N. / Varley, P.G. / Fisher, J. / Waltho, J.P. / Hunter, M.G. 履歴 登録 1999年1月11日 処理サイト : BNL改定 1.0 1999年7月22日 Provider : repository / タイプ : Initial release改定 1.1 2008年3月24日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2012年2月22日 Group : Database references改定 1.4 2021年11月3日 Group : Database references / Otherカテゴリ : database_2 / pdbx_database_status / struct_ref_seq_difItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _struct_ref_seq_dif.details
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