+データを開く
-基本情報
登録情報 | データベース: PDB化学物質要素 / ID: Z99 | ||||
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名称 | 名称: 別称: (1S,2S)-2-[(2S)-2-amino-1-hydroxy-1-oxo-3-(9H-xanthen-9-yl)propan-2-yl]cyclopropane-1-carboxylic acid 日化辞名称: LY-491395 ウィキペディア | ウィキペディア - LY-341495: LY-341495 is a research drug developed by the pharmaceutical company Eli Lilly, which acts as a potent and selective orthosteric antagonist for the group II metabotropic glutamate receptors (mGluR2/3).
| It is used in scientific research in several different areas, showing antidepressant effects in animal models, increasing the behavioural effects of hallucinogenic drugs in animal tests, and increasing the analgesic effects of μ-opioid agonists, as well as modulating dopamine receptor function. The 1-fluorocyclopropane analog has a superior pharmacokinetic profile and similar mGluR2/3 affinity, and making a prodrug from this with the heptyl ester increases bioavailability still further. ...コメント | 抗うつ薬, アンタゴニスト*YM | |
-Chemical information
組成 | 組成式: C20H19NO5 / 原子数: 45 / 化学式量: 353.369 / 形式電荷: 0 | ||||||||
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その他 | タイプ: NON-POLYMER / PDB分類: HETAIN / 3文字コード: Z99 / 理論座標の詳細: Corina / モデル座標のPDB-ID: 3KS9 | ||||||||
履歴 |
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外部リンク | BindingDB / UniChem / ChEBI / ChEMBL / ChemicalBook / GtoPharmacology / 日化辞 / PubChem / PubChem_TPharma / SureChEMBL / ZINC / ChemSpider / Wikipedia search / Google search |
-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-詳細
-SMILES
CACTVS 3.352 | OpenEye OEToolkits 1.7.0 | |
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-SMILES CANONICAL
CACTVS 3.352 | OpenEye OEToolkits 1.7.0 | |
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-InChI
InChI 1.03 |
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-InChIKey
InChI 1.03 |
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