+データを開く
-基本情報
登録情報 | データベース: PDB化学物質要素 / ID: CX5 | ||
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名称 | 名称: ウィキペディア | ウィキペディア - CX-516: CX-516 is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator and had been undergoing development by a collaboration between Cortex, Shire, and Servier. It was studied as a potential treatment for Alzheimer's disease under the brand name Ampalex, and was also being examined as a treatment for ADHD.
| CX-516 was the first ampakine compound developed by Cortex and while it showed good in vitro activity and positive results in animal tests, the human trials proved disappointing due mainly to low potency and short half-life... |
-Chemical information
組成 | 組成式: C14H15N3O / 原子数: 33 / 化学式量: 241.288 / 形式電荷: 0 | ||||
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その他 | タイプ: NON-POLYMER / PDB分類: HETAIN / 3文字コード: CX5 / 理論座標の詳細: Corina / モデル座標のPDB-ID: 4IY5 | ||||
履歴 |
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外部リンク | UniChem / BindingDB / ChEBI / ChEMBL / ChemicalBook / CompTox / DrugBank / GtoPharmacology / KEGG_Ligand / 日化辞 / PubChem / PubChem_TPharma / SureChEMBL / ZINC / ChemSpider / Wikipedia search / Google search |
-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-詳細
-SMILES
ACDLabs 12.01 | CACTVS 3.370 | OpenEye OEToolkits 1.7.6 | |
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-SMILES CANONICAL
CACTVS 3.370 | OpenEye OEToolkits 1.7.6 | |
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-InChI
InChI 1.03 |
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-InChIKey
InChI 1.03 |
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-SYSTEMATIC NAME
ACDLabs 12.01 | OpenEye OEToolkits 1.7.6 | |
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-PDBエントリ
全1件を表示しています
PDB-4iy5:
Crystal structure of the glua2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and CX516 at 2.0 A resolution