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データを開く
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基本情報
登録情報 | データベース: SASBDB / ID: SASDBA6 |
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![]() | Compound 1:BRD4 (2:1)
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機能・相同性 | ![]() RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ...RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() 類似検索 - 分子機能 |
生物種 | ![]() ![]() |
![]() | ![]() タイトル: Potent and selective bivalent inhibitors of BET bromodomains 著者: Waring M / Chen H / Rabow A / Walker G / Bobby R / Boiko S / Bradbury R / Callis R / Clark E / Dale I / Daniels D / Dulak A / Flavell L / Holdgate G / Jowitt T / Kikhney A / McAlister M / ...著者: Waring M / Chen H / Rabow A / Walker G / Bobby R / Boiko S / Bradbury R / Callis R / Clark E / Dale I / Daniels D / Dulak A / Flavell L / Holdgate G / Jowitt T / Kikhney A / McAlister M / Méndez J / Ogg D / Patel J / Petteruti P / Robb G / Robers M / Saif S / Stratton N / Svergun D / Wang W / Whittaker D / Wilson D |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
-モデル
モデル #590 | ![]() タイプ: dummy / ソフトウェア: DAMMIF (r2835) / ダミー原子の半径: 5.10 A / カイ2乗値: 2.140369 ![]() |
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モデル #770 | ![]() タイプ: mix / ソフトウェア: RANCH / ダミー原子の半径: 1.90 A / カイ2乗値: 2.211169 ![]() |
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試料
![]() | 名称: Compound 1:BRD4 (2:1) / 試料濃度: 1.00-10.00 |
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バッファ | 名称: 20mM Hepes, 100mM NaCl, 1mM Tris(2-carboxyethyl)phosphine hydrochloride pH: 7.4 |
要素 #394 | 名称: BRD4![]() ![]() 配列: MAHHHHHHSS GVDLGTENLY FQSMMSAESG PGTRLRNLPV MGDGLETSQM STTQAQAQPQ PANAASMNPP PPETSNPNKP KRQTNQLQYL LRVVLKTLWK HQFAWPFQQP VDAVKLNLPD YYKIIKTPMD MGTIKKRLEN NYYWNAQECI QDFNTMFTNC YIYNKPGDDI ...配列: MAHHHHHHSS GVDLGTENLY FQSMMSAESG PGTRLRNLPV MGDGLETSQM STTQAQAQPQ PANAASMNPP PPETSNPNKP KRQTNQLQYL LRVVLKTLWK HQFAWPFQQP VDAVKLNLPD YYKIIKTPMD MGTIKKRLEN NYYWNAQECI QDFNTMFTNC YIYNKPGDDI VLMAEALEKL FLQKINELPT EETEIMIVQA KGRGRGRKET GTAKPGVSTV PNTTQASTPP QTQTPQPNPP PVQATPHPFP AVTPDLIVQT PVMTVVPPQP LQTPPPVPPQ PQPPPAPAPQ PVQSHPPIIA ATPQPVKTKK GVKRKADTTT PTTIDPIHEP PSLPPEPKTT KLGQRRESSR PVKPPKKDVP DSQQHPAPEK SSKVSEQLKC CSGILKEMFA KKHAAYAWPF YKPVDVEALG LHDYCDIIKH PMDMSTIKSK LEAREYRDAQ EFGADVRLMF SNCYKYNPPD HEVVAMARKL QDVFEMRFAK MPDEPEEPVV AVSSPAVPPP T |
-実験情報
ビーム | 設備名称: ESRF BM29 / 地域: Grenoble / 国: France ![]() ![]() | |||||||||||||||||||||||||||
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検出器 | 名称: Pilatus 1M | |||||||||||||||||||||||||||
スキャン |
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距離分布関数 P(R) |
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結果 | コメント: A pool of 10000 models comprising two rigid bromodomains (residues 42-168, PDB ID: 2oss and 349-458, PDB ID: 2yem) connected by a flexible linker, N-terminal tag and flexible N- and C- ...コメント: A pool of 10000 models comprising two rigid bromodomains (residues 42-168, PDB ID: 2oss and 349-458, PDB ID: 2yem) connected by a flexible linker, N-terminal tag and flexible N- and C-termini were generated by the program RANCH (EOM). The scattering from each model from the pool was calculated with the program CRYSOL. For the 100 models best fitting the experimental scattering the histograms of the distances between the centres of the two bromodomains were computed; the average distance was 15±1 nm, the average Rg was 7.4±0.5 nm.
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