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- SASDG94: Autoinhibited dimer of truncated 6xHis Cytohesin-3 (Grp1, amino a... -
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Open data
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Basic information
Entry | Database: SASBDB / ID: SASDG94 |
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![]() | Autoinhibited dimer of truncated 6xHis Cytohesin-3 (Grp1, amino acids 14-399) with Inositol 1,3,4,5-tetrakis phosphate (antiparallel CORAL and MultiFoXS models)
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Function / homology | ![]() Intra-Golgi traffic / Golgi vesicle transport / establishment of epithelial cell polarity / regulation of ARF protein signal transduction / phosphatidylinositol-3,4,5-trisphosphate binding / positive regulation of cell adhesion / bicellular tight junction / ruffle / guanyl-nucleotide exchange factor activity / adherens junction ...Intra-Golgi traffic / Golgi vesicle transport / establishment of epithelial cell polarity / regulation of ARF protein signal transduction / phosphatidylinositol-3,4,5-trisphosphate binding / positive regulation of cell adhesion / bicellular tight junction / ruffle / guanyl-nucleotide exchange factor activity / adherens junction / nucleoplasm / plasma membrane / cytosol / cytoplasm Similarity search - Function |
Biological species | ![]() ![]() |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
-Data source
SASBDB page | ![]() |
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-Related structure data
Similar structure data |
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External links
Related items in Molecule of the Month |
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-Models
Model #3655 | ![]() Type: mix / Software: (CORAL05) / Radius of dummy atoms: 1.90 A / Symmetry: P1 Comment: Derived from Grp1 63-399 (2R09) and a canonical antiparallel coiled coil Chi-square value: 2.84 ![]() |
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Model #3656 | ![]() Type: atomic / Symmetry: P1 Comment: Derived from Grp1 63-399 (2R09) and a canonical antiparallel coiled coil Chi-square value: 0.859877586721 / P-value: 0.064794 ![]() |
Model #3657 | ![]() Type: atomic / Symmetry: P1 Comment: Derived from Grp1 63-399 (2R09) and a canonical antiparallel coiled coil Chi-square value: 0.859877586721 / P-value: 0.064794 ![]() |
Model #3658 | ![]() Type: atomic / Symmetry: P1 Comment: Derived from Grp1 63-399 (2R09) and a canonical antiparallel coiled coil Chi-square value: 0.859877586721 / P-value: 0.064794 ![]() |
Model #3659 | ![]() Type: atomic / Symmetry: P1 Comment: Derived from Grp1 63-399 (2R09) and a canonical antiparallel coiled coil Chi-square value: 0.859877586721 / P-value: 0.064794 ![]() |
Model #3660 | ![]() Type: atomic / Symmetry: P1 Comment: Derived from Grp1 63-399 (2R09) and a canonical antiparallel coiled coil Chi-square value: 0.859877586721 / P-value: 0.064794 ![]() |
Model #3661 | ![]() Type: atomic / Symmetry: P1 Comment: Derived from Grp1 63-399 (2R09) and a canonical antiparallel coiled coil Chi-square value: 0.859877586721 / P-value: 0.064794 ![]() |
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Sample
![]() | Name: Autoinhibited dimer of truncated 6xHis Cytohesin-3 (Grp1, amino acids 14-399) with Inositol 1,3,4,5-tetrakis phosphate (antiparallel CORAL and MultiFoXS models) Specimen concentration: 12 mg/ml |
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Buffer | Name: 20 mM Tris, 150 mM NaCl, 2 mM MgCl2, 0.1% 2-mercaptoethanol, 5% glycerol, 0.001 mM insitol 1,3,4,5-tetrakis phosphate pH: 8 |
Entity #1853 | Name: Cyth3, Grp1 / Type: protein / Description: Cytohesin-3 / Formula weight: 46.304 / Num. of mol.: 2 / Source: Mus musculus / References: UniProt: O08967 Sequence: MGHHHHHHGS EDLSLEEREE LLDIRRRKKE LIDDIERLKY EIAEVMTEID NLTSVEESKT TQRNKQIAMG RKKFNMDPKK GIQFLIENDL LQSSPEDVAQ FLYKGEGLNK TVIGDYLGER DDFNIKVLQA FVELHEFADL NLVQALRQFL WSFRLPGEAQ KIDRMMEAFA ...Sequence: MGHHHHHHGS EDLSLEEREE LLDIRRRKKE LIDDIERLKY EIAEVMTEID NLTSVEESKT TQRNKQIAMG RKKFNMDPKK GIQFLIENDL LQSSPEDVAQ FLYKGEGLNK TVIGDYLGER DDFNIKVLQA FVELHEFADL NLVQALRQFL WSFRLPGEAQ KIDRMMEAFA SRYCLCNPGV FQSTDTCYVL SFAIIMLNTS LHNHNVRDKP TAERFITMNR GINEGGDLPE ELLRNLYESI KNEPFKIPED DGNDLTHTFF NPDREGWLLK LGGRVKTWKR RWFILTDNCL YYFEYTTDKE PRGIIPLENL SIREVEDPRK PNCFELYNPS HKGQVIKACK TEADGRVVEG NHVVYRISAP SPEEKEEWMK SIKASISRDP FYDMLATRKR RIANKK |
-Experimental information
Beam | Instrument name: Advanced Photon Source (APS), Argonne National Laboratory BioCAT 18ID City: Lemont, IL / 国: USA ![]() | ||||||||||||||||||||||||||||||||||||
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Detector | Name: MAR 165 CCD | ||||||||||||||||||||||||||||||||||||
Scan | Measurement date: Nov 15, 2013 / Cell temperature: 20 °C / Exposure time: 1 sec. / Number of frames: 132 / Unit: 1/A /
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Distance distribution function P(R) |
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Result | Comments: The protein was equilibrated with a 1.2 molar excess of inositol 1,3,4,5-tetrakis phosphate (IP4) and concentrated to 12 mg/ml, prior to injection.
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