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データを開く
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基本情報
登録情報 | データベース: SASBDB / ID: SASDFK3 |
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![]() | Splicing factor, proline- and glutamine-rich (SFPQ)
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機能・相同性 | ![]() PTK6 Regulates Proteins Involved in RNA Processing / negative regulation of circadian rhythm / alternative mRNA splicing, via spliceosome / paraspeckles / Suppression of apoptosis / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / activation of innate immune response / RNA splicing / double-strand break repair via homologous recombination / regulation of circadian rhythm ...PTK6 Regulates Proteins Involved in RNA Processing / negative regulation of circadian rhythm / alternative mRNA splicing, via spliceosome / paraspeckles / Suppression of apoptosis / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / activation of innate immune response / RNA splicing / double-strand break repair via homologous recombination / regulation of circadian rhythm / mRNA processing / nuclear matrix / histone deacetylase binding / RNA polymerase II transcription regulator complex / rhythmic process / transcription cis-regulatory region binding / nuclear speck / chromatin remodeling / innate immune response / negative regulation of DNA-templated transcription / chromatin binding / regulation of DNA-templated transcription / chromatin / negative regulation of transcription by RNA polymerase II / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / nucleoplasm / nucleus / cytosol 類似検索 - 分子機能 |
生物種 | ![]() |
![]() | ![]() タイトル: A new crystal structure and small-angle X-ray scattering analysis of the homodimer of human SFPQ 著者: Hewage T / Caria S |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
-モデル
モデル #3006 | ![]() タイプ: mix / ダミー原子の半径: 1.90 A / カイ2乗値: 0.446 ![]() |
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モデル #3007 | ![]() タイプ: mix / ダミー原子の半径: 1.90 A / カイ2乗値: 0.372 ![]() |
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試料
![]() | 名称: Splicing factor, proline- and glutamine-rich (SFPQ) / 試料濃度: 5 mg/ml |
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バッファ | 名称: 20 mM Tris-HCl, 250 mM NaCl, 5% (v/v) glycerol / pH: 7.5 |
要素 #1494 | 名称: SFPQ / タイプ: protein / 記述: Splicing factor, proline- and glutamine-rich / 分子量: 30.049 / 分子数: 2 / 由来: Homo sapiens / 参照: UniProt: P23246 配列: GAMEGFKANL SLLRRPGEKT YTQRCRLFVG NLPADITEDE FKRLFAKYGE PGEVFINKGK GFGFIKLESR ALAEIAKAEL DDTPMRGRQL RVRFATHAAA LSVRNLSPYV SNELLEEAFS QFGPIERAVV IVDDRGRSTG KGIVEFASKP AARKAFERCS EGVFLLTTTP ...配列: GAMEGFKANL SLLRRPGEKT YTQRCRLFVG NLPADITEDE FKRLFAKYGE PGEVFINKGK GFGFIKLESR ALAEIAKAEL DDTPMRGRQL RVRFATHAAA LSVRNLSPYV SNELLEEAFS QFGPIERAVV IVDDRGRSTG KGIVEFASKP AARKAFERCS EGVFLLTTTP RPVIVEPLEQ LDDEDGLPEK LAQKNPMYQK ERETPPRFAQ HGTFEYEYSQ RWKSLDEMEK QQREQVEKNM KDAKDKLESE MEDAYHEHQA NLL |
-実験情報
ビーム | 設備名称: Australian Synchrotron SAXS/WAXS / 地域: Melbourne / 国: Australia ![]() | ||||||||||||||||||||||||||||||||||||
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検出器 | 名称: Pilatus 1M / タイプ: Dectris / Pixsize x: 172 mm | ||||||||||||||||||||||||||||||||||||
スキャン | 測定日: 2018年4月19日 / セル温度: 25 °C / 照射時間: 1 sec. / フレーム数: 4 / 単位: 1/A /
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距離分布関数 P(R) |
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結果 | コメント: CORAL was used to compare the scattering profile against the two PDB models of SFPQ in either P212121 or C2221 crystallographic space groups (CRYSOL fits to the data are shown; Coral ...コメント: CORAL was used to compare the scattering profile against the two PDB models of SFPQ in either P212121 or C2221 crystallographic space groups (CRYSOL fits to the data are shown; Coral models and fits are included in the full entry zip archive).
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