Entry | Database: PDB / ID: 6hnc |
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Title | Trypanosoma brucei PTR1 in complex with cycloguanil |
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Components | Pteridine reductase |
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Keywords | OXIDOREDUCTASE / Trypanosoma brucei / pteridine reductase / PTR1 / TbPTR1 / cycloguanil |
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Function / homology | Function and homology information
Pteridine reductase / Short-chain dehydrogenase/reductase, conserved site / Short-chain dehydrogenases/reductases family signature. / Enoyl-(Acyl carrier protein) reductase / Short-chain dehydrogenase/reductase SDR / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_eukaryote.gif) Trypanosoma brucei brucei (eukaryote) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.5 Å |
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Authors | Landi, G. / Pozzi, C. / Mangani, S. |
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Funding support | 1items Organization | Grant number | Country |
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European Commission | 603240 | |
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Citation | Journal: Acs Infect Dis. / Year: 2019 Title: Structural Insights into the Development of Cycloguanil Derivatives asTrypanosoma bruceiPteridine-Reductase-1 Inhibitors. Authors: Landi, G. / Linciano, P. / Borsari, C. / Bertolacini, C.P. / Moraes, C.B. / Cordeiro-da-Silva, A. / Gul, S. / Witt, G. / Kuzikov, M. / Costi, M.P. / Pozzi, C. / Mangani, S. |
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History | Deposition | Sep 14, 2018 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | May 8, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 24, 2019 | Group: Data collection / Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.name |
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Revision 1.2 | Jan 24, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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