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- SASDES5: Neurotrypsin Scavenger Receptor Cysteine-Rich Domain 3 (mmNT-SRCR... -

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Basic information

Entry
Database: SASBDB / ID: SASDES5
SampleNeurotrypsin Scavenger Receptor Cysteine-Rich Domain 3 (mmNT-SRCR3) - from SEC-SAXS
  • Mouse Neurotrypsin Scavenger Receptor Cysteine-Rich Domain 3 (protein), mmNT-SRCR3, Mus musculus
Function / homology
Function and homology information


zymogen activation / exocytosis / Hydrolases; Acting on peptide bonds (peptidases); Serine endopeptidases / synaptic cleft / Schaffer collateral - CA1 synapse / terminal bouton / peptidase activity / presynapse / cytoplasmic vesicle / axon ...zymogen activation / exocytosis / Hydrolases; Acting on peptide bonds (peptidases); Serine endopeptidases / synaptic cleft / Schaffer collateral - CA1 synapse / terminal bouton / peptidase activity / presynapse / cytoplasmic vesicle / axon / serine-type endopeptidase activity / dendrite / synapse / glutamatergic synapse / proteolysis / plasma membrane
Similarity search - Function
SRCR domain signature. / Scavenger receptor cysteine-rich domain / SRCR domain profile. / SRCR-like domain superfamily / Scavenger receptor Cys-rich / SRCR domain / Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily ...SRCR domain signature. / Scavenger receptor cysteine-rich domain / SRCR domain profile. / SRCR-like domain superfamily / Scavenger receptor Cys-rich / SRCR domain / Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Kringle-like fold / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Serine proteases, trypsin family, histidine active site. / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, serine active site. / Serine proteases, trypsin domain profile. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan
Similarity search - Domain/homology
Biological speciesMus musculus (house mouse)
CitationDate: 2019 Feb 12
Title: Structural characterization of the third scavenger receptor cysteine-rich domain of murine Neurotrypsin
Authors: Canciani A / Catucci G
Contact author
  • Federico Forneris (University of Pavia)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Models

Model #2450
Type: atomic
Comment: Model generated from PDB file by selecting only chain A
Chi-square value: 1.399
Search similar-shape structures of this assembly by Omokage search (details)

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Sample

SampleName: Neurotrypsin Scavenger Receptor Cysteine-Rich Domain 3 (mmNT-SRCR3) - from SEC-SAXS
Specimen concentration: 15 mg/ml
BufferName: 25 mM HEPES/NaOH, 0.1 M NaCl / pH: 8
Entity #1317Name: mmNT-SRCR3 / Type: protein
Description: Mouse Neurotrypsin Scavenger Receptor Cysteine-Rich Domain 3
Formula weight: 13.165 / Num. of mol.: 1 / Source: Mus musculus / References: UniProt: O08762
Sequence:
GTGEFTSGSG FPIRLVDGEN KKEGRVEVFV NGQWGTICDD GWTDKHAAVI CRQLGYKGPA RARTMAYFGE GKGPIHMDNV KCTGNEKALA DCVKQDIGRH NCRHSEDAGV ICDYLEKKAS S

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Experimental information

BeamInstrument name: ESRF BM29 / City: Grenoble / 国: France / Type of source: X-ray synchrotron / Wavelength: 0.09919 Å / Dist. spec. to detc.: 2.87 mm
DetectorName: Pilatus 1M / Type: Dectris / Pixsize x: 172 mm
Scan
Title: Neurotrypsin Scavenger Receptor Cysteine-Rich Domain 3 (mmNT-SRCR3) - from SEC-SAXS
Measurement date: May 20, 2017 / Storage temperature: 20 °C / Cell temperature: 20 °C / Exposure time: 1 sec. / Number of frames: 22 / Unit: 1/nm /
MinMax
Q0.0327 4.9445
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 1017 /
MinMax
Q0.155219 4.94445
P(R) point1 1017
R0 4.54
Result
Type of curve: sec
ExperimentalStandardStandard errorPorod
MW12 kDa11.99 kDa1 11.5 kDa
Volume---23.85 nm3

P(R)P(R) errorGuinierGuinier error
Forward scattering, I013.45 0.019 13.48 0.015
Radius of gyration, Rg1.53 nm0.003 1.54 nm0.03

MinMaxError
D-4.54 0.02
Guinier point27 173 -

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