+Open data
-Basic information
Entry | Database: SASBDB / ID: SASDEE2 |
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Sample | The N-terminal domain of estrogen receptor alpha
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Function / homology | Function and homology information regulation of epithelial cell apoptotic process / antral ovarian follicle growth / G protein-coupled estrogen receptor activity / regulation of branching involved in prostate gland morphogenesis / RUNX1 regulates transcription of genes involved in WNT signaling / RUNX1 regulates estrogen receptor mediated transcription / regulation of toll-like receptor signaling pathway / prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis / nuclear estrogen receptor activity / epithelial cell proliferation involved in mammary gland duct elongation ...regulation of epithelial cell apoptotic process / antral ovarian follicle growth / G protein-coupled estrogen receptor activity / regulation of branching involved in prostate gland morphogenesis / RUNX1 regulates transcription of genes involved in WNT signaling / RUNX1 regulates estrogen receptor mediated transcription / regulation of toll-like receptor signaling pathway / prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis / nuclear estrogen receptor activity / epithelial cell proliferation involved in mammary gland duct elongation / epithelial cell development / prostate epithelial cord elongation / negative regulation of smooth muscle cell apoptotic process / mammary gland branching involved in pregnancy / uterus development / vagina development / TFIIB-class transcription factor binding / androgen metabolic process / steroid hormone receptor signaling pathway / mammary gland alveolus development / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / estrogen receptor signaling pathway / cellular response to estrogen stimulus / estrogen response element binding / : / nuclear receptor-mediated steroid hormone signaling pathway / negative regulation of canonical NF-kappaB signal transduction / Nuclear signaling by ERBB4 / RNA polymerase II preinitiation complex assembly / negative regulation of miRNA transcription / protein localization to chromatin / 14-3-3 protein binding / cellular response to estradiol stimulus / transcription coregulator binding / nitric-oxide synthase regulator activity / steroid binding / TBP-class protein binding / ESR-mediated signaling / transcription corepressor binding / positive regulation of nitric-oxide synthase activity / SUMOylation of intracellular receptors / stem cell differentiation / nuclear estrogen receptor binding / positive regulation of DNA-binding transcription factor activity / Nuclear Receptor transcription pathway / euchromatin / negative regulation of DNA-binding transcription factor activity / Constitutive Signaling by Aberrant PI3K in Cancer / transcription coactivator binding / nuclear receptor activity / beta-catenin binding / positive regulation of fibroblast proliferation / response to estrogen / Regulation of RUNX2 expression and activity / male gonad development / PIP3 activates AKT signaling / positive regulation of nitric oxide biosynthetic process / sequence-specific double-stranded DNA binding / Ovarian tumor domain proteases / regulation of inflammatory response / response to estradiol / ATPase binding / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / phospholipase C-activating G protein-coupled receptor signaling pathway / positive regulation of cytosolic calcium ion concentration / DNA-binding transcription activator activity, RNA polymerase II-specific / fibroblast proliferation / transcription regulator complex / Estrogen-dependent gene expression / Extra-nuclear estrogen signaling / calmodulin binding / DNA-binding transcription factor activity, RNA polymerase II-specific / chromatin remodeling / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of gene expression / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / chromatin / regulation of DNA-templated transcription / protein kinase binding / enzyme binding / negative regulation of transcription by RNA polymerase II / Golgi apparatus / signal transduction / positive regulation of transcription by RNA polymerase II / protein-containing complex / zinc ion binding / nucleoplasm / identical protein binding / membrane / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function |
Biological species | Homo sapiens (human) |
Citation | Date: 2018 Dec Title: A Metastable Contact and Structural Disorder in the Estrogen Receptor Transactivation Domain Authors: Peng Y / Cao S / Kiselar J / Xiao X / Du Z / Hsieh A / Ko S / Chen Y / Agrawal P / Zheng W / Shi W / Jiang W / Yang L / Chance M / Surewicz W / Buck M |
Contact author |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Data source
SASBDB page | SASDEE2 |
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-Related structure data
Similar structure data |
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-External links
Related items in Molecule of the Month |
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-Models
Model #2229 | Type: atomic / Chi-square value: 0.136161 / P-value: 0.002500 Search similar-shape structures of this assembly by Omokage search (details) |
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Model #2230 | Type: atomic / Chi-square value: 0.341056 / P-value: 0.002500 Search similar-shape structures of this assembly by Omokage search (details) |
Model #2231 | Type: atomic / Chi-square value: 0.509796 / P-value: 0.002500 Search similar-shape structures of this assembly by Omokage search (details) |
-Sample
Sample | Name: The N-terminal domain of estrogen receptor alpha / Specimen concentration: 2.5 mg/ml |
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Buffer | Name: 20 mM sodium phosphate, 50 mM NaCl, 0.05 mM TCEP / pH: 7.4 |
Entity #1227 | Name: ER-NTD / Type: protein Description: The N-terminal domain of estrogen receptor alpha Formula weight: 20.175 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: P03372 Sequence: SNAMTMTLHT KASGMALLHQ IQGNELEPLN RPQLKIPLER PLGEVYLDSS KPAVYNYPEG AAYEFNAAAA ANAQVYGQTG LPYGPGSEAA AFGSNGLGGF PPLNSVSPSP LMLLHPPPQL SPFLQPHGQQ VPYYLENEPS GYTVREAGPP AFYRPNSDNR RQGGRERLAS TNDKGSMAME SAKETRY |
-Experimental information
Beam | Instrument name: National Synchrotron Light Source (NSLS-II) 16-ID (LiX) City: Brookhaven, NY / 国: USA / Type of source: X-ray synchrotron / Wavelength: 0.09 Å / Dist. spec. to detc.: 3 mm | |||||||||||||||||||||
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Detector | Name: Pilatus3 S 1M / Pixsize x: 172 mm | |||||||||||||||||||||
Scan | Title: The N-terminal domain of estrogen receptor alpha / Measurement date: Jun 12, 2017 / Cell temperature: 10 °C / Exposure time: 3 sec. / Number of frames: 3 / Unit: 1/A /
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Distance distribution function P(R) | Sofotware P(R): GNOM 4.6 / Number of points: 79 /
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Result | Experimental MW: 20.18 kDa / Type of curve: single_conc
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