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データを開く
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基本情報
登録情報 | データベース: SASBDB / ID: SASDEE2 |
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![]() | The N-terminal domain of estrogen receptor alpha
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機能・相同性 | ![]() regulation of epithelial cell apoptotic process / antral ovarian follicle growth / G protein-coupled estrogen receptor activity / regulation of branching involved in prostate gland morphogenesis / RUNX1 regulates transcription of genes involved in WNT signaling / RUNX1 regulates estrogen receptor mediated transcription / regulation of toll-like receptor signaling pathway / prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis / nuclear estrogen receptor activity / epithelial cell proliferation involved in mammary gland duct elongation ...regulation of epithelial cell apoptotic process / antral ovarian follicle growth / G protein-coupled estrogen receptor activity / regulation of branching involved in prostate gland morphogenesis / RUNX1 regulates transcription of genes involved in WNT signaling / RUNX1 regulates estrogen receptor mediated transcription / regulation of toll-like receptor signaling pathway / prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis / nuclear estrogen receptor activity / epithelial cell proliferation involved in mammary gland duct elongation / epithelial cell development / prostate epithelial cord elongation / negative regulation of smooth muscle cell apoptotic process / mammary gland branching involved in pregnancy / uterus development / vagina development / TFIIB-class transcription factor binding / androgen metabolic process / steroid hormone receptor signaling pathway / mammary gland alveolus development / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / estrogen receptor signaling pathway / cellular response to estrogen stimulus / estrogen response element binding / : / nuclear receptor-mediated steroid hormone signaling pathway / negative regulation of canonical NF-kappaB signal transduction / Nuclear signaling by ERBB4 / RNA polymerase II preinitiation complex assembly / negative regulation of miRNA transcription / protein localization to chromatin / 14-3-3 protein binding / cellular response to estradiol stimulus / transcription coregulator binding / nitric-oxide synthase regulator activity / steroid binding / TBP-class protein binding / ESR-mediated signaling / transcription corepressor binding / positive regulation of nitric-oxide synthase activity / SUMOylation of intracellular receptors / stem cell differentiation / nuclear estrogen receptor binding / positive regulation of DNA-binding transcription factor activity / Nuclear Receptor transcription pathway / euchromatin / negative regulation of DNA-binding transcription factor activity / Constitutive Signaling by Aberrant PI3K in Cancer / transcription coactivator binding / nuclear receptor activity / beta-catenin binding / positive regulation of fibroblast proliferation / response to estrogen / Regulation of RUNX2 expression and activity / male gonad development / PIP3 activates AKT signaling / positive regulation of nitric oxide biosynthetic process / sequence-specific double-stranded DNA binding / Ovarian tumor domain proteases / regulation of inflammatory response / response to estradiol / ATPase binding / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / phospholipase C-activating G protein-coupled receptor signaling pathway / positive regulation of cytosolic calcium ion concentration / DNA-binding transcription activator activity, RNA polymerase II-specific / fibroblast proliferation / transcription regulator complex / Estrogen-dependent gene expression / Extra-nuclear estrogen signaling / calmodulin binding / DNA-binding transcription factor activity, RNA polymerase II-specific / chromatin remodeling / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of gene expression / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / chromatin / regulation of DNA-templated transcription / protein kinase binding / enzyme binding / negative regulation of transcription by RNA polymerase II / Golgi apparatus / signal transduction / positive regulation of transcription by RNA polymerase II / protein-containing complex / zinc ion binding / nucleoplasm / identical protein binding / membrane / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 |
生物種 | ![]() |
![]() | ![]() タイトル: A Metastable Contact and Structural Disorder in the Estrogen Receptor Transactivation Domain 著者: Peng Y / Cao S / Kiselar J / Xiao X / Du Z / Hsieh A / Ko S / Chen Y / Agrawal P / Zheng W / Shi W / Jiang W / Yang L / Chance M / Surewicz W / Buck M |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
-モデル
モデル #2229 | ![]() タイプ: atomic / カイ2乗値: 0.136161 / P-value: 0.002500 ![]() |
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モデル #2230 | ![]() タイプ: atomic / カイ2乗値: 0.341056 / P-value: 0.002500 ![]() |
モデル #2231 | ![]() タイプ: atomic / カイ2乗値: 0.509796 / P-value: 0.002500 ![]() |
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試料
![]() | 名称: The N-terminal domain of estrogen receptor alpha / 試料濃度: 2.5 mg/ml |
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バッファ | 名称: 20 mM sodium phosphate, 50 mM NaCl, 0.05 mM TCEP / pH: 7.4 |
要素 #1227 | 名称: ER-NTD / タイプ: protein / 記述: The N-terminal domain of estrogen receptor alpha / 分子量: 20.175 / 分子数: 1 / 由来: Homo sapiens / 参照: UniProt: P03372 配列: SNAMTMTLHT KASGMALLHQ IQGNELEPLN RPQLKIPLER PLGEVYLDSS KPAVYNYPEG AAYEFNAAAA ANAQVYGQTG LPYGPGSEAA AFGSNGLGGF PPLNSVSPSP LMLLHPPPQL SPFLQPHGQQ VPYYLENEPS GYTVREAGPP AFYRPNSDNR RQGGRERLAS TNDKGSMAME SAKETRY |
-実験情報
ビーム | 設備名称: National Synchrotron Light Source (NSLS-II) 16-ID (LiX) 地域: Brookhaven, NY / 国: USA ![]() | |||||||||||||||||||||
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検出器 | 名称: Pilatus3 S 1M / Pixsize x: 172 mm | |||||||||||||||||||||
スキャン | 測定日: 2017年6月12日 / セル温度: 10 °C / 照射時間: 3 sec. / フレーム数: 3 / 単位: 1/A /
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距離分布関数 P(R) |
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結果 |
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