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- PDB-9y8w: MERS Mpro with EGT710 -

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Basic information

Entry
Database: PDB / ID: 9y8w
TitleMERS Mpro with EGT710
Components3C-like proteinase nsp5
KeywordsHYDROLASE / Mpro MERS Covid
Function / homology
Function and homology information


host cell membrane / Lyases; Phosphorus-oxygen lyases / Hydrolases; Acting on ester bonds; Exoribonucleases producing 5'-phosphomonoesters / host cell endoplasmic reticulum-Golgi intermediate compartment / 5'-3' DNA helicase activity / endonuclease activity / 3'-5'-RNA exonuclease activity / symbiont-mediated degradation of host mRNA / mRNA guanylyltransferase / symbiont-mediated suppression of host ISG15-protein conjugation ...host cell membrane / Lyases; Phosphorus-oxygen lyases / Hydrolases; Acting on ester bonds; Exoribonucleases producing 5'-phosphomonoesters / host cell endoplasmic reticulum-Golgi intermediate compartment / 5'-3' DNA helicase activity / endonuclease activity / 3'-5'-RNA exonuclease activity / symbiont-mediated degradation of host mRNA / mRNA guanylyltransferase / symbiont-mediated suppression of host ISG15-protein conjugation / G-quadruplex RNA binding / omega peptidase activity / mRNA (guanine-N7)-methyltransferase / methyltransferase cap1 / symbiont-mediated suppression of host NF-kappaB cascade / DNA helicase / symbiont-mediated perturbation of host ubiquitin-like protein modification / methyltransferase cap1 activity / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity / mRNA 5'-cap (guanine-N7-)-methyltransferase activity / Hydrolases; Acting on peptide bonds (peptidases); Cysteine endopeptidases / RNA helicase activity / single-stranded RNA binding / regulation of autophagy / viral protein processing / lyase activity / host cell perinuclear region of cytoplasm / RNA helicase / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / symbiont-mediated suppression of host gene expression / viral translational frameshifting / symbiont-mediated activation of host autophagy / RNA-directed RNA polymerase / cysteine-type endopeptidase activity / viral RNA genome replication / RNA-directed RNA polymerase activity / DNA-templated transcription / ATP hydrolysis activity / proteolysis / zinc ion binding / ATP binding / membrane
Similarity search - Function
RNA-dependent RNA polymerase, Middle East respiratory syndrome-related coronavirus / Non-structural protein 2, MERS-CoV-like / NSP3, SUD-C domain, MERS-CoV-like / AAA domain / Nonstructural protein 14, betacoronavirus / Nonstructural protein 15, middle domain, alpha/betacoronavirus / Nonstructural protein 15, N-terminal domain, alpha/beta-coronavirus / NSP14, guanine-N7-methyltransferase domain, coronavirus / Coronavirus (CoV) guanine-N7-methyltransferase (N7-MTase) domain profile. / Coronavirus (CoV) Nsp15 N-terminal oligomerization domain profile. ...RNA-dependent RNA polymerase, Middle East respiratory syndrome-related coronavirus / Non-structural protein 2, MERS-CoV-like / NSP3, SUD-C domain, MERS-CoV-like / AAA domain / Nonstructural protein 14, betacoronavirus / Nonstructural protein 15, middle domain, alpha/betacoronavirus / Nonstructural protein 15, N-terminal domain, alpha/beta-coronavirus / NSP14, guanine-N7-methyltransferase domain, coronavirus / Coronavirus (CoV) guanine-N7-methyltransferase (N7-MTase) domain profile. / Coronavirus (CoV) Nsp15 N-terminal oligomerization domain profile. / NSP12 RNA-dependent RNA polymerase, coronavirus / : / Coronavirus Nsp12 RNA-dependent RNA polymerase (RdRp) domain profile. / Coronavirus Nsp12 Interface domain profile. / : / : / Coronavirus Nonstructural protein 13, 1B domain / Coronavirus Non-structural protein 13, zinc-binding domain / Coronavirus Nonstructural protein 13, stalk domain / Nidovirus 2-O-methyltransferase / Nidovirus 2'-O-methyltransferase (2'-O-MTase) domain profile. / Non-structural protein NSP15, N-terminal domain superfamily, coronavirus / Non-structural protein NSP15, middle domain superfamily / Coronavirus replicase NSP15, N-terminal oligomerization / Nonstructural protein 15, middle domain, coronavirus / Nonstructural protein 13, 1B domain, coronavirus / Coronavirus replicase NSP15, middle domain / Coronavirus replicase NSP15, N-terminal oligomerisation / Nidovirus 3'-5' exoribonuclease domain / Nidovirus 3'-5' exoribonuclease (ExoN) domain profile. / Non-structural protein NSP16, coronavirus-like / Non-structural protein 14, coronavirus / RNA polymerase, N-terminal, coronavirus / Coronavirus 2'-O-methyltransferase / Coronavirus proofreading exoribonuclease / Coronavirus RNA-dependent RNA polymerase, N-terminal / Nonstructural protein 13, zinc-binding domain, coronavirus-like / Coronaviridae zinc-binding (CV ZBD) domain profile. / Arterivirus Nsp11 N-terminal/Coronavirus NSP15 middle domain / Arterivirus Nsp11 N-terminal/coronavirus NSP15 middle (AV-Nsp11N/CoV-Nsp15M) domain profile. / Nidoviral uridylate-specific endoribonuclease (NendoU) domain profile. / Nidovirus RdRp-associated nucleotidyl transferase (NiRAN) domain / Nidovirus RdRp-associated nucleotidyl transferase (NiRAN) domain profile. / Endoribonuclease EndoU-like / NendoU domain, nidovirus / Coronavirus replicase NSP15, uridylate-specific endoribonuclease / : / DNA2/NAM7 helicase-like, C-terminal / AAA domain / (+) RNA virus helicase core domain / (+)RNA virus helicase core domain profile. / Betacoronavirus single-stranded poly(A) binding domain / Betacoronavirus Nsp3c-M domain profile. / NSP1, globular domain, betacoronavirus / Non-structural protein NSP3, SUD-M domain, betacoronavirus / Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirus / Betacoronavirus replicase NSP1 / NSP1, C-terminal domain, betacoronavirus / Betacoronavirus (BetaCoV) Nsp1 C-terminal domain profile. / : / Betacoronavirus Nsp3e group 2-specific marker (G2M) domain profile. / Betacoronavirus Nsp3c-C domain profile. / Betacoronavirus Nsp3e nucleic acid-binding (NAB) domain profile. / DPUP/SUD, C-terminal, betacoronavirus / Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirus / Non-structural protein NSP3A domain-like superfamily / Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirus / Non-structural protein 6, betacoronavirus / Betacoronavirus nucleic acid-binding (NAB) / Papain-like viral protease, palm and finger domains, coronavirus / Papain-like protease, N-terminal domain superfamily, coronavirus / Coronavirus replicase NSP2, N-terminal / : / Coronavirus replicase NSP2, C-terminal / Coronavirus (CoV) Nsp2 middle domain profile. / NSP1, globular domain, alpha/betacoronavirus / Coronavirus (CoV) Nsp1 globular domain profile. / Coronavirus (CoV) Nsp2 N-terminal domain profile. / Coronavirus (CoV) Nsp2 C-terminal domain profile. / Nonstructural protein 2, N-terminal domain, coronavirus / Non-structural protein 2, C-terminal domain, coronavirus / NSP3, second ubiquitin-like (Ubl) domain, coronavirus / Coronavirus Nsp3a Ubl domain profile. / Coronavirus Nsp3d Ubl domain profile. / NSP3, first ubiquitin-like (Ubl) domain, coronavirus / Peptidase family C16 domain profile. / Coronavirus replicase NSP7 / : / : / Coronavirus 3Ecto domain profile. / Coronavirus RNA-dependent RNA polymerase (RdRp) Nsp7 cofactor domain profile. / Coronavirus RNA-dependent RNA polymerase (RdRp) Nsp8 cofactor domain profile. / Coronavirus Nsp9 single-stranded RNA (ssRNA)-binding domain profile. / Coronavirus (CoV) ExoN/MTase coactivator domain profile. / Coronavirus (CoV) Nsp3 Y domain profile. / Coronavirus Nsp4 C-terminal (Nsp4C) domain profile. / Coronavirus main protease (M-pro) domain profile. / Peptidase C30, coronavirus / Peptidase C16, coronavirus / Non-structural protein NSP9, coronavirus
Similarity search - Domain/homology
: / Replicase polyprotein 1ab
Similarity search - Component
Biological speciesMiddle East respiratory syndrome-related coronavirus
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.04 Å
AuthorsKnapp, M.S. / Ornelas, E.
Funding support1items
OrganizationGrant numberCountry
Not funded
CitationJournal: Npj Drug Discov / Year: 2025
Title: Preclinical characterization of EGT710, an oral non-peptidomimetic reversible covalent SARS-CoV-2 main protease inhibitor
Authors: Moquin, S.A. / Lakshminarayana, S.B. / Balavenkatraman, K.K. / Schiller, H. / Claas, A. / Bhhatarai, B. / Loisios-Konstantinidis, I. / Vulic, K. / Kurhade, C. / Kalveram, B.K. / Chen, J.Y.C. ...Authors: Moquin, S.A. / Lakshminarayana, S.B. / Balavenkatraman, K.K. / Schiller, H. / Claas, A. / Bhhatarai, B. / Loisios-Konstantinidis, I. / Vulic, K. / Kurhade, C. / Kalveram, B.K. / Chen, J.Y.C. / Zou, J. / Xie, X. / Tandeske, L. / Dovala, D. / Ornelas, E. / Knapp, M.S. / Fuller, D. / Nguyen, Z. / Barkan, D.T. / Bebrevska, L. / Wright, S.K. / Busby, S.A. / Blais, J. / Shi, P.Y. / Gaudet, S. / Bergeron, R. / Yu, H. / Zack, J. / Sarko, C. / Gu, F. / Bradner, J.E. / Tallarico, J.A. / Diagana, T.T. / Papillon, J.P.N.
History
DepositionSep 11, 2025Deposition site: RCSB / Processing site: RCSB
Revision 1.0Dec 24, 2025Provider: repository / Type: Initial release

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: 3C-like proteinase nsp5
B: 3C-like proteinase nsp5
C: 3C-like proteinase nsp5
D: 3C-like proteinase nsp5
hetero molecules


Theoretical massNumber of molelcules
Total (without water)134,9588
Polymers133,4174
Non-polymers1,5414
Water724
1
A: 3C-like proteinase nsp5
C: 3C-like proteinase nsp5
hetero molecules


Theoretical massNumber of molelcules
Total (without water)67,4794
Polymers66,7082
Non-polymers7712
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area2370 Å2
ΔGint-19 kcal/mol
Surface area24310 Å2
MethodPISA
2
B: 3C-like proteinase nsp5
hetero molecules

D: 3C-like proteinase nsp5
hetero molecules


Theoretical massNumber of molelcules
Total (without water)67,4794
Polymers66,7082
Non-polymers7712
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
crystal symmetry operation2_455-x-1/2,-y,z+1/21
Buried area2220 Å2
ΔGint-15 kcal/mol
Surface area24760 Å2
MethodPISA
Unit cell
Length a, b, c (Å)87.114, 94.645, 153.924
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number19
Space group name H-MP212121
Space group name HallP2ac2ab
Symmetry operation#1: x,y,z
#2: x+1/2,-y+1/2,-z
#3: -x,y+1/2,-z+1/2
#4: -x+1/2,-y,z+1/2

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Components

#1: Protein
3C-like proteinase nsp5 / 3CL-PRO / 3CLp / nsp5


Mass: 33354.172 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Middle East respiratory syndrome-related coronavirus
Gene: rep, 1a-1b / Production host: Escherichia coli (E. coli)
References: UniProt: K9N7C7, Hydrolases; Acting on peptide bonds (peptidases); Cysteine endopeptidases
#2: Chemical
ChemComp-A1CBU / (4S)-4-(iminomethyl)-3-(isoquinolin-4-yl)-1-[6-(trifluoromethyl)pyridin-3-yl]imidazolidin-2-one


Mass: 385.343 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C19H14F3N5O / Feature type: SUBJECT OF INVESTIGATION
#3: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 4 / Source method: isolated from a natural source / Formula: H2O
Has ligand of interestY
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.38 Å3/Da / Density % sol: 48.28 %
Crystal growTemperature: 294 K / Method: vapor diffusion, hanging drop
Details: 0.1M Hepes pH 7.5, 8% Ethylene Glycol, 10% Peg 8000

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: ALS / Beamline: 5.0.1 / Wavelength: 0.97741 Å
DetectorType: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Jul 3, 2024
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.97741 Å / Relative weight: 1
ReflectionResolution: 3.04→80.62 Å / Num. obs: 23704 / % possible obs: 94.3 % / Redundancy: 4.4 % / Biso Wilson estimate: 32.69 Å2 / CC1/2: 0.901 / Net I/σ(I): 4
Reflection shellResolution: 3.04→3.2 Å / Num. unique obs: 3589 / CC1/2: 0.43

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Processing

Software
NameVersionClassification
PHENIX1.21.2_5419+SVNrefinement
autoPROCdata reduction
Aimlessdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 3.04→75.81 Å / SU ML: 0.483 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 25.5811
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.278 1174 4.99 %
Rwork0.2281 22338 -
obs0.2305 23512 93.25 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 31.48 Å2
Refinement stepCycle: LAST / Resolution: 3.04→75.81 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms9030 0 112 4 9146
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00199382
X-RAY DIFFRACTIONf_angle_d0.442312810
X-RAY DIFFRACTIONf_chiral_restr0.03931450
X-RAY DIFFRACTIONf_plane_restr0.00351724
X-RAY DIFFRACTIONf_dihedral_angle_d10.90813279
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
3.04-3.180.35641450.30382824X-RAY DIFFRACTION95.99
3.18-3.340.34511680.28692893X-RAY DIFFRACTION98.08
3.34-3.550.35381280.27712483X-RAY DIFFRACTION84.88
3.55-3.830.29361480.23632602X-RAY DIFFRACTION88.37
3.83-4.210.27351270.21022601X-RAY DIFFRACTION86.91
4.21-4.820.22191740.18572890X-RAY DIFFRACTION97.02
4.82-6.070.26981260.20363001X-RAY DIFFRACTION98.15
6.08-75.810.21241580.19253044X-RAY DIFFRACTION96.16
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
10.330772119778-0.09009640404540.3135507549950.3172849208210.1746989062380.500857852319-0.1215442526810.1091424820280.0235706515308-0.1978090254780.0607856451824-0.2384456314340.0105357190240.1732955126680.06457368247980.183109642422-0.0189142153722-0.0191534315950.1300268662640.03194096703070.432066977291-28.690031301910.030849112723.9054694739
20.970510555276-0.1105822732260.09575013581311.215459714850.06387924305891.32738137252-0.1836087886790.06043177291860.495711572798-0.2928898975880.1697314510770.0595265446722-0.312292857862-0.2351190709710.2014329782540.4060819058010.0339850548315-0.0007749728727670.2368939154470.04125067443430.604097630376-33.147614753521.503612048219.6636634712
30.10388889008-0.1726289260550.07502786391230.279189994073-0.1072827236250.582286606062-0.08744951655220.08189475408430.06968056846750.00662524787413-0.015983585687-0.01388802434520.1404674098710.171837303163-0.01201467366890.214202168037-0.0626880508674-0.03344434366860.1172025585580.02151354670040.307597856517-33.20420571765.3536318564227.1855473102
40.463013344898-0.419006653456-0.2582823387320.6128575205660.4865599308980.412506515426-0.0697705422049-0.0268244894878-0.0885534717911-0.04808973461450.05044721146450.13979952653-0.04488248556320.002666947130670.05305819702970.240977501954-0.1145318353260.003394477724060.1058465863920.1076093660980.532163687249-36.11436026482.4218457935124.4010292118
50.524654499264-0.09706571356250.06327200832680.502771665637-0.1497036270680.431528969978-0.02589577848550.0157570534263-0.236548309954-0.03311330118640.0554401730871-0.2864205461790.1491750184480.0172205342737-0.05031551434030.290917123442-7.32321128104E-50.02602038981980.1587687098880.03226187455530.432441742944-33.7606846873-17.298980401631.0984782838
60.392944245583-0.3256445539920.0968579748380.7376321303870.4768989936390.8095326824270.01289299208550.07774736378470.00589602419434-0.381343755336-0.10669282701-0.2017766695870.1007292546440.0067930816987-0.1098894423420.241438364989-0.06035301040410.06526268787210.270759850690.0511135625180.330171205015-42.5517464353-15.937799342927.9357905253
70.985245327636-0.5237351132030.2779101196010.501492908374-0.1285024369780.841701453107-0.121073770768-0.1541112186450.0213934511378-0.03408930113020.04024210279510.187746491891-0.209048444437-0.06658409042770.03579643433540.2642298331660.08554117734510.001657437546910.210545552223-0.1038545916860.584328429614-16.7734485917.4039241794654.3980018354
80.8973857116850.210188358144-0.5519634838370.414281478082-0.295981994690.534939600263-0.413870269398-0.276627639630.2290398341010.2296076857060.0577691084945-0.2826986137-0.2152154117540.02302305536170.005342983541240.5751440455840.078802827933-0.05660870902790.26950196117-0.1642414223570.606745324355-12.910111682819.166140933458.365061991
90.31091286304-0.08001179698370.02330371016890.446206704587-0.1112105672330.546665122146-0.0869949307963-0.02670923996890.193353584058-0.130244853858-0.08900287456240.166364901729-0.278406292007-0.2606568308740.02018119430740.2494018294650.0564129661584-0.03222391548090.219996762421-0.03617314298510.431293501545-10.93487570382.5600850113451.2530773747
100.498399856758-0.3439087117330.2518404087240.814762669394-0.1820428366350.5707519213010.07134721537670.01784196966370.0114674360928-0.154826056617-0.0001306861072010.2347843152810.0804101507993-0.0536490531331-0.03604445364850.262563890129-0.006882791332830.03070210130720.155901240389-0.02923401886150.361539319237-7.94958448916-19.496583494346.6371329922
110.379979507589-0.1565635984210.02505268132660.275875726075-0.001337056418420.439379325945-0.01338884573910.0293976307759-0.222371336328-0.06096008221350.0383973822167-0.04383025034450.0888626215029-0.1358659926990.06309130698980.252430497851-0.0529671907655-0.02904974606730.0984712914053-0.03897124381410.487685564927-65.0357879836-2.9524197890716.733585324
122.18436573529-0.1907947458230.2730331264440.912655186096-0.4994491401311.7976341302-0.14990397366-0.376943385270.5303498795610.1526268877750.0152202901897-0.250608941486-0.3285662719880.08486378827660.07082354428840.2265168751340.02444025203750.0470360431270.245731657559-0.04076538082850.672019263042-68.64354873347.7507738848123.3046607588
130.527139893838-0.266673203952-0.03468394761150.1474244352970.05234955658680.4020060282660.0385488440444-0.0005635795291480.01814493496660.0187649576442-0.141121777602-0.118983772321-0.0434340643903-0.115916558763-0.03171980693530.204828562834-0.0311678374048-0.0828107249390.0834725717048-0.009161597959380.410790894483-58.4361243383-2.5003472327812.8253847641
140.285936718511-0.223134499790.1552501752360.5269356167350.06183340318220.4227995147640.088559944133-0.102283667063-0.175978431865-0.09812423219020.112598049296-0.04521416706150.0987386508567-0.01039323283190.2184753586850.27663480374-0.0637777756809-0.0367451897422-0.0511843700018-0.02837795231310.583466315821-58.6893653356-8.4980426923612.578830523
150.9949740494230.02174796592970.07893047598080.342137680165-0.1198484507920.6106623969190.151173242382-0.0273447332273-0.1217141649860.202516398985-0.1825581784340.1617776330680.1183254416310.197955454875-0.07448143489210.3432100926190.01314519335150.03262538944220.169072867864-0.01442201122090.394079124297-36.8573875598-19.20540957912.8032424028
161.17068828904-0.02844828635520.3072582645460.249813504965-0.01831499142770.8308174564420.125052310265-0.0323363564832-0.107541464234-0.182438241703-0.03614432888060.1235128069260.0448624589762-0.364362946030.004005955619420.3445448581210.0136320088672-0.05217144200330.213223270730.01749237348470.435777300341-60.29094745520.344582231814-17.7085328951
171.393096598270.1801372074440.1679001007420.642112044905-0.3098815632750.9498498480820.12692392710.0820668107627-0.06442793971-0.2085187927610.09560433513260.32491160650.0854083372389-0.1734057752780.002381160527530.350792681344-0.051641991632-0.05151904633980.5328385011350.07165802268660.495677041161-72.6002664364-2.5117311257-19.8858826805
180.743558128071-0.006070049658430.1809118993860.473912175856-0.08120663620120.898110581278-0.0628073560622-0.205754302415-0.1257097165990.04797405711320.2197046477650.0097743178779-0.204109336798-0.2140961399340.007315401310220.3776351479720.02838241295420.05127526329120.1940592438750.01150772101990.493062925476-58.7693642624.43276866525-12.4983897487
190.936665613268-0.2178618659290.2129275228630.0767631513177-0.1708835001240.585339210147-0.00551285752701-0.1873636122710.2362211420030.165370794906-0.09209622961910.105507757622-0.3484718103950.02017827492490.09434286279640.477163854866-0.01661828771450.0372036320290.229851182714-0.06772751671990.485065141523-39.016707172720.7734754625-2.21596032533
Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

IDRefine TLS-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
11chain 'A' and (resid 1 through 62 )AA1 - 621 - 62
22chain 'A' and (resid 63 through 79 )AA63 - 7963 - 79
33chain 'A' and (resid 80 through 142 )AA80 - 14280 - 142
44chain 'A' and (resid 143 through 158 )AA143 - 158143 - 158
55chain 'A' and (resid 159 through 283 )AA159 - 283159 - 283
66chain 'A' and (resid 284 through 300 )AA284 - 300284 - 300
77chain 'B' and (resid 1 through 62 )BC1 - 621 - 62
88chain 'B' and (resid 63 through 79 )BC63 - 7963 - 79
99chain 'B' and (resid 80 through 158 )BC80 - 15880 - 158
1010chain 'B' and (resid 159 through 300 )BC159 - 300159 - 300
1111chain 'C' and (resid 1 through 62 )CE1 - 621 - 62
1212chain 'C' and (resid 63 through 79 )CE63 - 7963 - 79
1313chain 'C' and (resid 80 through 142 )CE80 - 14280 - 142
1414chain 'C' and (resid 143 through 192 )CE143 - 192143 - 192
1515chain 'C' and (resid 193 through 300 )CE193 - 300193 - 300
1616chain 'D' and (resid 1 through 48 )DG1 - 481 - 48
1717chain 'D' and (resid 49 through 79 )DG49 - 7949 - 79
1818chain 'D' and (resid 80 through 192 )DG80 - 19280 - 192
1919chain 'D' and (resid 193 through 301 )DG193 - 301193 - 301

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