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- PDB-9tdl: Complex between complement C5 and cobra venom factor, re-refined -

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Basic information

Entry
Database: PDB / ID: 9tdl
TitleComplex between complement C5 and cobra venom factor, re-refined
Components
  • (Cobra venom factor ...) x 3
  • (Complement C5 ...) x 2
KeywordsIMMUNE SYSTEM / innate immunity / complement / proteolytic regulation
Function / homology
Function and homology information


Terminal pathway of complement / membrane attack complex / negative regulation of macrophage chemotaxis / Activation of C3 and C5 / complement activation, GZMK pathway / other organism cell membrane / complement activation / complement activation, alternative pathway / chemokine activity / endopeptidase inhibitor activity ...Terminal pathway of complement / membrane attack complex / negative regulation of macrophage chemotaxis / Activation of C3 and C5 / complement activation, GZMK pathway / other organism cell membrane / complement activation / complement activation, alternative pathway / chemokine activity / endopeptidase inhibitor activity / positive regulation of vascular endothelial growth factor production / complement activation, classical pathway / positive regulation of chemokine production / Regulation of Complement cascade / Peptide ligand-binding receptors / chemotaxis / toxin activity / killing of cells of another organism / G alpha (i) signalling events / cell surface receptor signaling pathway / inflammatory response / G protein-coupled receptor signaling pathway / signaling receptor binding / : / extracellular exosome / extracellular region / metal ion binding
Similarity search - Function
: / Complement component 5, CUB domain / Complement C3-like, NTR domain / : / : / Complement component 3, CUB domain, second segment / Complement component 3, CUB domain, first segment / Alpha-2-macroglobulin, conserved site / Alpha-2-macroglobulin family thiolester region signature. / : ...: / Complement component 5, CUB domain / Complement C3-like, NTR domain / : / : / Complement component 3, CUB domain, second segment / Complement component 3, CUB domain, first segment / Alpha-2-macroglobulin, conserved site / Alpha-2-macroglobulin family thiolester region signature. / : / Alpha-macro-globulin thiol-ester bond-forming region / Complement C3/4/5, macroglobulin domain MG1 / Macroglobulin domain MG1 / Anaphylatoxin, complement system domain / Anaphylatoxin domain signature. / Anaphylatoxin, complement system / Anaphylatoxin/fibulin / Anaphylotoxin-like domain / Anaphylatoxin domain profile. / Anaphylatoxin homologous domain / Netrin C-terminal Domain / Netrin module, non-TIMP type / UNC-6/NTR/C345C module / Macroglobulin domain MG4 / Macroglobulin domain MG4 / Alpha-macroglobulin, receptor-binding / Alpha-macroglobulin, receptor-binding domain superfamily / Macroglobulin domain MG3 / : / A-macroglobulin receptor binding domain / Macroglobulin domain MG3 / A-macroglobulin receptor / Netrin domain / NTR domain profile. / Alpha-2-macroglobulin / Macroglobulin domain / Alpha-2-macroglobulin, bait region domain / Alpha-macroglobulin-like, TED domain / Alpha-2-macroglobulin family / MG2 domain / A-macroglobulin TED domain / Alpha-2-macroglobulin bait region domain / Alpha-2-Macroglobulin / Alpha-2-macroglobulin family / Tissue inhibitor of metalloproteinases-like, OB-fold / Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid / Immunoglobulin-like fold
Similarity search - Domain/homology
Complement C5 / Cobra venom factor
Similarity search - Component
Biological speciesHomo sapiens (human)
Naja kaouthia (monocled cobra)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 4.3 Å
AuthorsAndersen, G.R.
Funding support Denmark, 1items
OrganizationGrant numberCountry
Not funded Denmark
CitationJournal: EMBO J / Year: 2011
Title: Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Authors: Laursen, N.S. / Andersen, K.R. / Braren, I. / Spillner, E. / Sottrup-Jensen, L. / Andersen, G.R.
History
DepositionNov 24, 2025Deposition site: PDBE / Processing site: PDBE
SupersessionJul 29, 2026ID: 3PVM
Revision 1.0Jul 29, 2026Provider: repository / Type: Initial release

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Complement C5 beta chain
C: Complement C5 alpha chain
J: Cobra venom factor alpha chain
K: Cobra venom factor gamma chain
L: Cobra venom factor beta chain
B: Complement C5 beta chain
D: Complement C5 alpha chain
M: Cobra venom factor alpha chain
N: Cobra venom factor gamma chain
O: Cobra venom factor beta chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)657,40517
Polymers655,24710
Non-polymers2,1587
Water00
1
A: Complement C5 beta chain
C: Complement C5 alpha chain
J: Cobra venom factor alpha chain
K: Cobra venom factor gamma chain
L: Cobra venom factor beta chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)328,6948
Polymers327,6245
Non-polymers1,0703
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
B: Complement C5 beta chain
D: Complement C5 alpha chain
M: Cobra venom factor alpha chain
N: Cobra venom factor gamma chain
O: Cobra venom factor beta chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)328,7129
Polymers327,6245
Non-polymers1,0884
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)176.520, 179.200, 389.690
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number17
Space group name H-MP2221
Space group name HallP2c2
Symmetry operation#1: x,y,z
#2: x,-y,-z
#3: -x,y,-z+1/2
#4: -x,-y,z+1/2
Noncrystallographic symmetry (NCS)NCS domain:
IDEns-IDDetails (eV)
d_1ens_1(chain "A" and (resid 23 through 662 or resid 680 through 1676 or resid 1677 through 1678))
d_2ens_1(chain "C" and (resid 23 through 1676 or resid 1677 through 1678))
d_1ens_2(chain "B" and (resid 23 through 151 or resid 157 through 1642 or resid 1643 through 1644))
d_2ens_2(chain "D" and (resid 23 through 151 or resid 157...

NCS domain segments:
Dom-IDComponent-IDEns-IDBeg auth comp-IDBeg label comp-IDEnd auth comp-IDEnd label comp-IDAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
d_11ens_1TYRTYRSERSERAA23 - 6625 - 644
d_12ens_1GLNGLNCYSCYSCB680 - 16763 - 999
d_13ens_1NAGNAGNAGNAGGK1
d_14ens_1NAGNAGNAGNAGGK2
d_21ens_1TYRTYRCYSCYSB - DF - G23 - 16765 - 999
d_22ens_1NAGNAGNAGNAGIM1
d_23ens_1NAGNAGNAGNAGIM2
d_11ens_2ALAALAASPASPJC23 - 1511 - 129
d_12ens_2METMETTHRTHRJ - LC - E157 - 1642135 - 379
d_13ens_2NAGNAGNAGNAGJN1701
d_14ens_2NAGNAGNAGNAGHL1
d_21ens_2ALAALAASPASPMH23 - 1511 - 129
d_22ens_2METMETGLNGLNMH157 - 646135 - 624
d_23ens_2GLUGLUTHRTHRN - OI - J736 - 16424 - 379
d_24ens_2NAGNAGNAGNAGMP1701
d_25ens_2NAGNAGNAGNAGOQ1701

NCS ensembles :
ID
ens_1
ens_2

NCS oper:
IDCodeMatrixVector
1given(0.00807590252786, 0.99820179464, 0.0593966074468), (0.998700527979, -0.0110404225499, 0.049753034919), (0.0503193323892, 0.0589176225568, -0.996993820713)87.7252162065, -83.3004566481, -99.1710958968
2given(0.0131450173065, 0.998013417966, 0.0616151448884), (0.9991875289, -0.0154583564737, 0.0372199046958), (0.0380984331757, 0.0610758280725, -0.99740576127)87.7559527754, -84.4703811674, -97.3047057385

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Components

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Complement C5 ... , 2 types, 4 molecules ABCD

#1: Protein Complement C5 beta chain / Complement C5


Mass: 73361.453 Da / Num. of mol.: 2 / Source method: isolated from a natural source
Details: Complement C5. Notice that in the comparison sequence, a signal peptide in residues 1-18 and a propeptide in residues 674-677 are removed prior to secretion from the C5 producing cell
Source: (natural) Homo sapiens (human) / References: UniProt: P01031
#2: Protein Complement C5 alpha chain / Complement C5


Mass: 112635.008 Da / Num. of mol.: 2 / Source method: isolated from a natural source
Details: Complement C5. Notice that in the comparison sequence, a signal peptide in residues 1-18 and a propeptide in residues 674-677 are removed prior to secretion from the C5 producing cell
Source: (natural) Homo sapiens (human) / References: UniProt: P01031

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Cobra venom factor ... , 3 types, 6 molecules JMKNLO

#3: Protein Cobra venom factor alpha chain / Cobra venom factor


Mass: 69581.984 Da / Num. of mol.: 2 / Source method: isolated from a natural source
Details: Cobra venom factor. Notice that relative to the the comparison sequence, a signal peptide in residues 1-22, a propeptide in residues 650-732 and second propeptide in residues 985-1263 are ...Details: Cobra venom factor. Notice that relative to the the comparison sequence, a signal peptide in residues 1-22, a propeptide in residues 650-732 and second propeptide in residues 985-1263 are removed prior to secretion from the CVF producing cell
Source: (natural) Naja kaouthia (monocled cobra) / References: UniProt: Q91132
#4: Protein Cobra venom factor gamma chain / Cobra venom factor


Mass: 28418.568 Da / Num. of mol.: 2 / Source method: isolated from a natural source
Details: Cobra venom factor. Notice that relative to the the comparison sequence, a signal peptide in residues 1-22, a propeptide in residues 650-732 and second propeptide in residues 985-1263 are ...Details: Cobra venom factor. Notice that relative to the the comparison sequence, a signal peptide in residues 1-22, a propeptide in residues 650-732 and second propeptide in residues 985-1263 are removed prior to secretion from the CVF producing cell
Source: (natural) Naja kaouthia (monocled cobra) / References: UniProt: Q91132
#5: Protein Cobra venom factor beta chain / Cobra venom factor


Mass: 43626.547 Da / Num. of mol.: 2 / Source method: isolated from a natural source
Details: Cobra venom factor. Notice that relative to the the comparison sequence, a signal peptide in residues 1-22, a propeptide in residues 650-732 and second propeptide in residues 985-1263 are ...Details: Cobra venom factor. Notice that relative to the the comparison sequence, a signal peptide in residues 1-22, a propeptide in residues 650-732 and second propeptide in residues 985-1263 are removed prior to secretion from the CVF producing cell
Source: (natural) Naja kaouthia (monocled cobra) / References: UniProt: Q91132

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Sugars , 2 types, 7 molecules

#6: Polysaccharide 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 424.401 Da / Num. of mol.: 3
Source method: isolated from a genetically manipulated source
DescriptorTypeProgram
DGlcpNAcb1-4DGlcpNAcb1-Glycam Condensed SequenceGMML 1.0
WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1WURCSPDB2Glycan 1.1.0
[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}}}LINUCSPDB-CARE
#7: Sugar
ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C8H15NO6 / Feature type: SUBJECT OF INVESTIGATION
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Details

Has ligand of interestY
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 4.13 Å3/Da / Density % sol: 70.21 %
Crystal growTemperature: 277 K / Method: vapor diffusion
Details: Crystals were grown at in vapour diffusion experiments by mixing equal volumes of protein with a reservoir solution containing 1.1 to 1.3 M sodium malonate, pH 7.4

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: ESRF / Beamline: ID14-4 / Wavelength: 0.9765 Å
DetectorType: ADSC QUANTUM 315r / Detector: CCD / Date: Mar 12, 2010
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9765 Å / Relative weight: 1
ReflectionResolution: 4.3→49.47 Å / Num. obs: 79835 / % possible obs: 94.2 % / Redundancy: 5.6 % / Biso Wilson estimate: 135.19 Å2 / Rsym value: 0.143 / Net I/σ(I): 10.9
Reflection shellResolution: 4.3→4.43 Å / Mean I/σ(I) obs: 3.1 / Num. unique obs: 6842 / Rsym value: 0.625

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Processing

Software
NameVersionClassification
PHENIX1.21.2_5419refinement
XDSdata reduction
XSCALEdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 4.3→49.47 Å / SU ML: 0.5725 / Cross valid method: FREE R-VALUE / σ(F): 1.35 / Phase error: 26.0116
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2572 1734 2.17 %
Rwork0.2016 78099 -
obs0.2028 79833 94.25 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 194.15 Å2
Refinement stepCycle: LAST / Resolution: 4.3→49.47 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms45229 0 140 0 45369
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.006346331
X-RAY DIFFRACTIONf_angle_d0.974962873
X-RAY DIFFRACTIONf_chiral_restr0.0597203
X-RAY DIFFRACTIONf_plane_restr0.00758011
X-RAY DIFFRACTIONf_dihedral_angle_d14.415117287
Refine LS restraints NCS
Ens-IDDom-IDAsym-IDAuth asym-IDRefine-IDTypeRms dev position (Å)
ens_1d_2AAX-RAY DIFFRACTIONTorsion NCS0.878569308444
ens_2d_2BCX-RAY DIFFRACTIONTorsion NCS0.889534071503
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
4.3-4.430.33891530.27676524X-RAY DIFFRACTION95.98
4.43-4.570.30361460.24836559X-RAY DIFFRACTION96.13
4.57-4.730.26881430.22596533X-RAY DIFFRACTION95.69
4.73-4.920.23121430.2076535X-RAY DIFFRACTION95.7
4.92-5.150.25951470.20246550X-RAY DIFFRACTION95.59
5.15-5.420.29471460.2086524X-RAY DIFFRACTION95.22
5.42-5.760.30941470.21616484X-RAY DIFFRACTION94.76
5.76-6.20.27961470.21526526X-RAY DIFFRACTION94.51
6.2-6.820.25171350.21476516X-RAY DIFFRACTION94.11
6.82-7.80.22751460.1926447X-RAY DIFFRACTION92.96
7.81-9.820.20691390.15426484X-RAY DIFFRACTION92.44
9.82-49.470.24551420.18416417X-RAY DIFFRACTION88.35
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
18.230928973711.003554881641.523308994546.014958326641.038770207525.934362993870.5209587229181.011419906111.19576390215-0.238322927524-0.590664405061-0.180133088465-0.9053006295-0.6616872967690.0921041179631.3958950750.3330892665650.08586351363531.60756517330.4778611492741.5624344362186.2374873577-25.7873401937-77.7811447548
25.656954202544.46818937529-2.842846963385.34920845498-1.642330758617.35126906482-0.0999146213051-0.02182649180060.3869628952310.747337732891-0.0452978113192-0.161622764975-0.228460183999-0.0505952921690.0434751825161.688695554250.1698328022360.015118754091.550221020070.1348893492411.7196731975975.6709665782-43.6934883262-45.8443772263
33.964888956621.45607190587-1.553636844270.6982690427240.3376294158665.2112893695-0.1979949634880.367718631045-0.126123968596-0.08146267236340.08402755322590.1680644173580.85424410895-0.2924213574270.08570469614742.665285401160.03968457613290.326508072632.066014979490.1011696780852.476279877976.4202883174-80.4761830126-47.4418166744
43.47454976056-0.175707365105-2.586336801916.6874831816-5.194902107747.198035879970.259922465810.836142831577-0.05578726485230.00886534011668-0.1347753820880.6851788449771.02712573956-0.277335719341-0.0164978890581.74828206993-0.2694195626630.1529580171812.13042486488-0.03848774747191.5786472533795.2449253736-67.2947342257-77.479757827
57.506712445631.775116300130.3151588528636.978262639812.878776790089.267174314150.2980330612050.1995566022170.1966210046-0.2015280600770.331150497557-0.272264243326-0.116902108526-0.13691471809-0.583067378921.383720743560.02870992704520.07286934810661.872141998630.2344829359311.63518355191102.559860129-42.886431531-78.6777952003
62.144497041870.1160151065640.7065421525565.73941363079-1.452650320411.64319211606-0.4979846868960.4269288230580.2058154029810.2488824100390.336997870205-0.446142113772-0.1081952706830.2129641022490.1990356345692.112400553080.0886476867258-0.009169539206712.453236390210.2964099664772.0072027417393.7714096343-49.3189386849-37.7522358219
72.725392924680.60912690535-4.116267333651.94114659261-0.5227070382766.78715042075-0.3122332076470.257915803151-0.1752080132650.5041374483020.6574871308680.3802561372980.0672985103291-1.77807420465-0.3572887891781.546806801010.00327750890472-0.00457077260522.074102674070.1970217494491.9619179214587.1442947239-47.7231682824-68.6406151452
88.420496430322.626369045672.063552147855.37610117652-0.03780042414216.3154689416-0.4727744982360.0249991695042-0.324177912931-0.599767001976-0.3991234123581.03642974471.02447544661-0.40112717540.9333825032182.5534194714-0.1281149575990.1221914606311.99726483431-0.1761604540862.3569689322152.8443680594-80.8852909573-40.614048161
96.13847841505-4.14723205561-2.314808530462.943612134580.4669969596874.346153904890.130510784583-0.3207401556940.3353989078340.2986182738420.4119883806090.123652679384-0.36187152529-0.0212513547294-0.4518097085752.073307725010.1551308756830.2265190265531.419404561670.2181374109831.8306046387488.5031500722-67.8817351887-9.20844787322
101.56245186116-2.0678556325-1.236268948165.37021739751.605185133193.11813211874-0.132644974022-0.551446959701-0.07884069153170.160446128388-0.148561591852-0.391218124394-0.2731238747380.6040527236660.09079140674881.965716858510.07326305413420.2789088018562.075669705850.0201876292991.6821934071459.8646764936-37.9716500122-0.0655168787365
114.482163211890.8925520519720.05473343885673.258434818191.247045361075.63897535793-0.2076771375180.0472810879152-0.318968895558-0.00605755369116-0.08602689113350.1669814800410.223803854788-0.07346863773230.2734368371541.535194261640.06664089610260.1910997692161.33438557022-0.02578389427171.4928431751345.5829051128-40.8915069495-25.207024132
125.75187985754-1.771828584843.449363590053.71722352598-0.8738319001445.65121298256-0.2349909064110.0106213105325-1.275148899140.06612173986370.07935794713060.1842719998441.10254283229-0.2969415004720.2029290057072.00312238531-0.02575878113530.4253758912321.67072999030.06913904909351.958751226954.8162732116-70.0898533321-16.3408477098
134.115022458491.123384397120.561315518677.68838067711-2.729626782663.14542560938-0.0519178631126-1.69926884506-0.3236987970553.67597617842-0.348959497558-0.499385781041-1.35807703940.38059144170.4531319001113.235032937750.03071308295820.07434303020872.485617883760.3451072303181.7133724698866.2386846023-65.17674961723.0702469955
146.843196585120.7335919982290.376286506313.98735926082-1.394182571243.25980891813-0.0168247509833-0.0889729337826-0.2401201560140.6742333802650.287594483615-1.238543846110.6849708669280.625457870824-0.5173599276931.51108732150.292174131121-0.2237702680891.60064143932-0.03330637442741.4252723457257.9703622331-1.2950944465-18.7063363951
156.394459072314.555337153525.222846079875.542127225521.352602787477.672746507960.0327568804085-0.2952582703120.3350634209760.441133263697-0.283931632196-0.16171087727-0.228541405942-0.1876293630120.3012248668941.707263168880.1790958182280.0173371089711.72256396606-0.08362181096311.5975226110141.9804815606-9.69715763061-52.1657184685
164.021035032460.726972327483-2.634466485752.18940620512-0.3675673524816.915073138540.314922308403-0.6491504060690.4542043154680.602600722792-0.348319883231-0.16577309888-0.330534712505-0.571377287094-0.006413348448431.72806271143-0.155740013511-0.1457297479692.18117902787-0.4463510580662.166100701714.96966800356-8.03929861663-53.2002350778
173.9159194407-2.82854687756-0.05593799164473.986198143830.682506700918.11315154829-0.009522115980121.01793836628-1.19554247238-0.461975245514-0.1462604944440.8583276494280.429563603775-1.317036384160.2425881635811.65221200657-0.155108759464-0.03907863753411.8824953196-0.5077899806431.693588085716.59897075268.8365546037-21.1760617357
188.746749904533.24236955583-2.68692716918.53516610022-2.838687345585.524986249780.1135240517820.2763356840430.04619477273370.1947495719860.266420724826-0.046739479238-0.2459601877230.212604057808-0.5150143642781.540649924620.0974780175032-0.2171290772091.44046275627-0.2153233182371.56403303341.1296200615.3542212163-17.9822501448
197.58043768625-1.087961950161.921570991372.111476596580.5999626757667.077880456390.2702218585250.4621692911480.4879830543010.394414782888-0.6873396318570.3014943438350.09992843426510.05666751659590.388975839841.526658644269.1987968368E-5-0.1065994795041.308019262250.001234411483491.4221214757237.23138073398.83371685314-59.719568377
201.633053240690.06856609645920.8795595508311.816168706983.785968228627.208217605230.6496876993860.457204101236-0.2084803920390.0357420197315-0.09235582359140.2334548598571.846031944630.719097552186-1.46677090092.29881042514-0.044277062711-0.1651872943041.76612451652-0.1637058253751.9994661355436.74608822890.566487226183-29.3209717163
213.120289277521.367615038170.5984988312648.58764825730.5490083492361.18717806601-0.0413039363325-1.17116857594-0.4605763752640.789641742013-0.4361114856870.9551033350340.637836847809-0.4883190346140.4049302352052.29303741824-0.1358597061230.2622484694622.501171259170.07880533640232.410252495445.09945105721-31.2420083595-60.9299699193
222.91908334401-2.480774224940.7074419310576.368095172090.7727518002761.861642432230.2486152831730.6750071999790.357125778611-0.664765034546-0.4738593775270.0723347036804-0.37423772087-0.05330459741640.3263532649261.840438784830.238379595823-0.157213028382.25916959818-0.1326085401781.9392388272920.31241045.38046288826-89.5706480021
233.94498650103-1.629318789961.982973287513.160646814261.413683141573.150127588710.2446616885730.333065431920.147232599623-0.268613728507-0.148239147843-0.00637326252454-0.4204667116110.7901314242250.02365095584762.077398152760.1273327381930.02276917191432.20068070548-0.108914609381.693993591250.532640369-22.8325464631-98.3117199739
244.25012616710.857838029975-1.227592889614.33219359317-0.0992702407964.213563151790.009564124708790.230116117466-0.3639917912320.176691287406-0.2645882746610.2456176339570.21060999611-0.1192661880550.2682946677731.506239710860.08866636741570.02996733121741.53662282591-0.1389497098821.5877567848545.9548092475-38.3207932812-74.0941850844
252.72477178839-1.250479525651.966595752466.54174897703-4.419532060697.519961775170.03136968447830.0411477503551-0.298390054876-0.167085464097-0.2724478537611.07218490405-0.207572854495-0.9364977285640.3246045060961.66706139292-0.081188613093-0.0377353717231.7422332469-0.3813122920421.8026755803617.3756746662-28.4718369668-84.2138335817
265.669982996931.28420342232-0.5681310934087.129960039252.752168640547.608291199270.3657134397912.921023407670.125945522819-1.52800211865-0.2130898015010.55991585792-1.02506810778-1.13568879177-0.1164534711812.088687639010.6606888171430.03522422455723.09113142684-0.1213496389821.7813309596123.9757742021-15.8673326154-122.507356227
275.9771790529-1.23659764230.8952189461443.3575625037-0.3518861100144.863055892840.4889825389320.270742144731-1.202160275230.364253835724-0.154944456885-0.07788930222281.248413145720.99130719278-0.01775940293982.511824712110.370693018090.1380318568982.132129393820.05863514918242.24372956895135.750256856-79.2803057061-80.4753784759
288.71924107113-1.403208463261.065108107248.465467021620.9013028812829.068487122170.3066471938560.698924828879-0.253204507139-0.7786864105510.119320675333-0.6831565660820.7103989105270.294532318732-0.5166631661981.75520209012-0.0009826709175740.1571161741061.418255723970.1090032465831.72586163372137.312017137-76.2762966639-42.3621338262
294.550356716540.1400455763970.7603791394997.94339623219-5.707420156978.838109706070.1313410040160.339135373340.6113280578170.748858227115-0.01597288065030.171263137049-1.360743674540.675008190509-0.1105834268722.133031239430.0357028798563-0.03798925016241.705476907460.1261895136191.74507462108129.083573694-43.9937157134-32.8183886557
300.672748765499-0.1976774557580.28362979084.15319285061-1.000183855918.923179489650.0003811912523570.2037775018370.300955948060.440954751421-0.345777142593-0.221301053822-0.7055229001510.8121380951270.344164329231.60994580808-0.0982893049957-0.06261737072251.878751152670.3347323048351.94867960647123.499496817-43.1489077464-67.2916431107
312.8103213831-1.249155331251.998926529576.26821488725-1.84688359236.152129226670.02611384481640.414962555328-0.108610900164-0.1364849560250.146372727810.1545399683670.3309156355530.00760308800335-0.05806847861781.532288231810.0716956911010.06104706419722.02865274090.2368161967861.66568347832118.800462069-62.4828098272-79.9693838839
321.44233965014-1.14653880443-1.139519363423.521405821731.833748420163.176100968870.2056717799060.2085612377910.0423221419809-0.424309976912-0.1050045072610.238903853268-0.597651232665-0.5831862276450.07543705504891.65011712881-0.01188170866480.03115507589241.670563147970.1862241526241.80097757718114.420413474-75.8452705926-34.7971719749
33-0.0825217356402-0.1198752438080.1543763273710.352763375697-1.804392771128.176453338770.0880035153298-0.1715924114720.10128716463-0.2040163587920.180434210354-0.2004028945460.7133158333331.46365228427-0.4497738672372.030459325120.08689053673230.05578406565351.995724222620.09229876573082.01472562104132.71011396-63.7199787304-66.1257158558
346.63242996174-0.7621880138820.4883641514713.17819813442-0.7732968567853.59864051354-0.599451640784-0.391712202382-0.1727582323510.9782807386290.5544889432430.1280722158980.188758598581-0.449296534117-0.01777008957192.05745125770.1426732170830.1545792079651.420027499620.0949262015831.74830135049122.750001579-67.3218265019-7.25823242017
356.38987003317-0.596504980594-0.4669472115110.9739165890642.403884962727.72193421540.3091154873940.1679838349130.0196333115471-0.0903654263458-0.0833860192149-0.1520310223840.7161225561830.38864546616-0.1867419721562.166089209940.2383911387870.1212783628871.56796639530.3042855099561.98667150587157.216150633-82.8538334907-33.500197767
367.282987070043.01645298373-3.586486140215.01416888466-3.988452741087.85286289634-0.0887223312584-0.1795384200330.8903870205071.228281328680.2955515439310.399376820071-0.719329080347-0.0307436896567-0.3601989577562.525801927410.224138352305-0.1532834516711.364838977520.00891791143531.67278293335131.058982477-46.7023943587-5.00199489095
373.985033492930.621299121485-2.336289419394.61028930608-4.653238190736.095179092120.168664989549-0.3694246083490.5607202701660.828577438349-0.514771584262-0.558633456222-1.160752650590.1572658938260.2849936980911.5285166175-0.0320633100205-0.1288987187171.15542151408-0.002645192553441.31230454488138.902379697-81.473988354817.025055993
384.970255611310.0217877400169-0.7229017255095.11631654098-1.106088396223.86602150325-0.1135346970370.1968074295280.02168317084420.01412171881190.5278475127070.938156559738-0.719105070727-0.873247264843-0.166390048082.066783881460.484591253262-0.1212163015372.55082042207-0.2126831771581.954273156025.3739722386649.2589412727-16.6350626882
396.43964762857-3.69902110511-0.9346642481557.63401959706-1.621400327518.04829846341-0.245600297664-0.3394441765080.7371616227540.3976409179820.1466003584720.238070225831-0.604153556777-0.6060803260080.06489546268181.60947458275-0.0141456555351-0.243922370981.75688275919-0.2162875024241.7492243672310.845364954952.8735046953-54.7706929403
408.87686976919-0.7672786428464.98580265534.99195689674-2.860442346994.955376116390.3256651751440.767854834128-0.643205827790.355255538908-0.149558109416-0.495318897397-0.5043535020471.03693732779-0.3447744267361.74534003310.103135915597-0.09051412028812.171603178490.0199835233271.6378146259743.633887425743.8707675114-62.3447493201
411.371609956590.741594511059-2.470270240271.846670941210.610845067758.46172900816-0.440517857355-0.266861048884-0.001334836215970.2094968639960.348237938057-0.458544369236-0.2997967895581.135777332190.1753851365181.789888329410.143339129736-0.3605909882081.99211361147-0.02529944896421.9723598648542.159905982536.7254747193-28.109405853
426.58208545227-0.2920670254671.981336995814.26087289806-2.124335425815.178643505380.3841783566620.294572715731-0.5102893058180.0660693365008-0.2137870911440.06896009863460.278002232613-0.0107345777097-0.2237113708991.684683625180.181818880463-0.1596425452931.82685418646-0.1552211011791.5584242117321.93982724632.010768122-17.0259137387
433.55010108827-2.32942605833-2.940722524124.354280386071.051785446768.83848800127-0.09441834341830.0464187333601-0.1274721307320.05875243002280.0881353149367-0.01601117688481.1230860149-0.13298095740.03528766027391.68466566557-0.0597049180884-0.1768498053551.67795056447-0.05641557625141.6728066565611.346965689230.1445255293-63.0370278813
440.0309802985322-0.4370720535580.644208389951.36908646117-2.019650426482.64139079304-0.255351306951-0.3149151268950.432112159233-0.0527871884255-0.164376962568-0.338539652661-1.036301592210.08193006086950.467740024012.206081846950.251800175291-0.2052673017752.38746164919-0.2472049038872.0642774789422.149483321546.6485055482-29.8198067567
451.77527890553-1.12743888638-0.8791538439258.522269157130.6517218697073.774733729910.2800377590190.01662710418770.171546159242-0.3363524530280.0981965801427-0.251965114160.17603792287-0.280216582342-0.4828534734771.717677489280.00869066054759-0.08444079443521.899779588430.008120649021461.8252643582421.799617309739.528029406-89.6193710118
463.99333701113-1.27347664689-4.329926768765.164999515041.611044537317.88281748813-0.292484467528-0.4654769538570.545940873856-0.248855837410.3849771842880.615290964514-0.0490575825973-0.412499218198-0.3028256234341.703572141520.234069220857-0.184080475082.21542784657-0.03938829933442.026255157085.2019648073172.9357133005-63.0151106565
476.457228521121.051763215633.47242187957.44988470881-0.4269546282623.896095232140.09900384607570.711602389217-0.249107805779-0.209074440438-0.133580693601-0.5175742504080.229179034150.9671409072860.06705119299241.568247726510.1370915807260.05731080179142.26433878680.08402821441141.604886390742.658647377947.4544238888-90.1386036952
484.285041868270.04207901862593.627343998424.155649347173.039967944927.42105230949-0.2938146367980.4283509435850.405359373323-0.1759682248860.219622343618-0.233718805034-0.437747124270.4984761979580.1138228797861.24864048385-0.05214938798510.02659406043341.126769929880.1228571758331.212881605878.8043134666355.314434448-113.914678312
Refinement TLS group
IDRefine-IDRefine TLS-IDAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
1X-RAY DIFFRACTION1AA23 - 1221 - 100
2X-RAY DIFFRACTION2AA123 - 224101 - 202
3X-RAY DIFFRACTION3AA225 - 350203 - 328
4X-RAY DIFFRACTION4AA351 - 458329 - 436
5X-RAY DIFFRACTION5AA459 - 566437 - 544
6X-RAY DIFFRACTION6AA567 - 821545 - 783
7X-RAY DIFFRACTION7AA607 - 662585 - 640
8X-RAY DIFFRACTION8AA679 - 760641 - 722
9X-RAY DIFFRACTION9AA822 - 931784 - 893
10X-RAY DIFFRACTION10AA932 - 1372894 - 1334
11X-RAY DIFFRACTION11AA982 - 1306944 - 1268
12X-RAY DIFFRACTION12AA1373 - 15141335 - 1474
13X-RAY DIFFRACTION13AA - C1515 - 16781475
14X-RAY DIFFRACTION14CH23 - 1221 - 100
15X-RAY DIFFRACTION15CH123 - 224101 - 202
16X-RAY DIFFRACTION16CH225 - 350203 - 328
17X-RAY DIFFRACTION17CH351 - 458329 - 436
18X-RAY DIFFRACTION18CH459 - 566437 - 544
19X-RAY DIFFRACTION19CH567 - 821545 - 782
20X-RAY DIFFRACTION20CH607 - 662585 - 640
21X-RAY DIFFRACTION21CH680 - 760641 - 721
22X-RAY DIFFRACTION22CH822 - 931783 - 892
23X-RAY DIFFRACTION23CH932 - 1372893 - 1333
24X-RAY DIFFRACTION24CH982 - 1306943 - 1267
25X-RAY DIFFRACTION25CH1373 - 15141334 - 1473
26X-RAY DIFFRACTION26CH - J1515 - 16781474
27X-RAY DIFFRACTION27BD23 - 1251 - 103
28X-RAY DIFFRACTION28BD126 - 220104 - 195
29X-RAY DIFFRACTION29BD221 - 340196 - 315
30X-RAY DIFFRACTION30BD341 - 437316 - 412
31X-RAY DIFFRACTION31BD438 - 542413 - 517
32X-RAY DIFFRACTION32BD543 - 812518 - 698
33X-RAY DIFFRACTION33BD583 - 646558 - 621
34X-RAY DIFFRACTION34BD813 - 917699 - 803
35X-RAY DIFFRACTION35BD918 - 1336804 - 922
36X-RAY DIFFRACTION36BD1337 - 1473923 - 1051
37X-RAY DIFFRACTION37BD - G1474 - 16451052

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