PDB-9puk: Neutralizing monoclonal antibody Fab fragment for human leptin

ID or keywords:

Entry

Database: PDB / ID: 9puk

Title

Neutralizing monoclonal antibody Fab fragment for human leptin

Components

Neutralizing monoclonal antibody Fab fragment for human leptin, heavy chain
Neutralizing monoclonal antibody Fab fragment for human leptin, light chain

Keywords

IMMUNE SYSTEM / Antibody / FAB / leptin

Biological species

Homo sapiens (human)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 3.3 Å

Authors

Tomchick, D.R. / Wynn, R.M. / Scherer, P.E.

Funding support

United States, 12items

Organization	Grant number	Country
National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)	DK55758	United States
National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)	DK099110	United States
National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)	DK118620	United States
National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)	DK127274	United States
National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)	DK131537	United States
National Institutes of Health/National Institute on Aging (NIH/NIA)	AG051459	United States
National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)	DK138935	United States
National Institutes of Health/National Institute on Aging (NIH/NIA)	AG084646	United States
Cancer Prevention and Research Institute of Texas (CPRIT)	RP220032	United States
Cancer Prevention and Research Institute of Texas (CPRIT)	RP150551	United States
Cancer Prevention and Research Institute of Texas (CPRIT)	RP190561	United States
Robert A. Welch Foundation	AU-0042-20030616	United States

Citation

Journal: Sci Adv / Year: 2025
Title: Leptin as a key driver for organ fibrogenesis.
Authors: Sun, X.N. / Chen, S. / Zhao, S. / Funcke, J.B. / Virostek, M. / Pedersen, L. / Li, C. / Joung, C. / Lin, Q. / Li, Y. / Cobb, A. / Wang, M.Y. / Min, K. / Maya-Ramos, L. / Degasperi, G. / Liu, ...

History

Deposition	Jul 31, 2025	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Nov 5, 2025	Provider: repository / Type: Initial release

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	9puk.cif.gz	556 KB	Display	PDBx/mmCIF format
PDB format	pdb9puk.ent.gz	388.7 KB	Display	PDB format
PDBx/mmJSON format	9puk.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Summary document	9puk_validation.pdf.gz	452.7 KB	Display	wwPDB validaton report
Full document	9puk_full_validation.pdf.gz	462 KB	Display
Data in XML	9puk_validation.xml.gz	32.8 KB	Display
Data in CIF	9puk_validation.cif.gz	41.5 KB	Display
Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/pu/9puk ftp://data.pdbj.org/pub/pdb/validation_reports/pu/9puk	HTTPS FTP

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Related structure data

Related structure data	9puoC C: citing same article (ref.)

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#21 - Sep 2001 Antibodies similarity (1) #256 - Apr 2021 SARS-CoV-2 Spike and Antibodies similarity (1) #149 - May 2012 Leptin similarity (1)

Deposited unit

A: Neutralizing monoclonal antibody Fab fragment for human leptin, heavy chain

B: Neutralizing monoclonal antibody Fab fragment for human leptin, light chain

C: Neutralizing monoclonal antibody Fab fragment for human leptin, heavy chain

D: Neutralizing monoclonal antibody Fab fragment for human leptin, light chain

93.2 kDa, 4 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Neutralizing monoclonal antibody Fab fragment for human leptin, heavy chain

B: Neutralizing monoclonal antibody Fab fragment for human leptin, light chain

defined by author
Evidence: assay for oligomerization
46.6 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

C: Neutralizing monoclonal antibody Fab fragment for human leptin, heavy chain

D: Neutralizing monoclonal antibody Fab fragment for human leptin, light chain

defined by author
Evidence: assay for oligomerization
46.6 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	70.215, 207.941, 72.823
Angle α, β, γ (deg.)	90.000, 90.000, 90.000
Int Tables number	18
Space group name H-M	P2₁2₁2
Space group name Hall	P22ab
Symmetry operation	#1: x,y,z #2: x+1/2,-y+1/2,-z #3: -x+1/2,y+1/2,-z #4: -x,-y,z

Noncrystallographic symmetry (NCS)

NCS domain:

ID	Ens-ID	Details
d_1	ens_1	(chain "A" and (resid 2 through 100 or resid 108 through 222))
d_2	ens_1	(chain "C" and (resid 2 through 100 or resid 108 through 135 or resid 143 through 222))
d_1	ens_2	chain "B"
d_2	ens_2	(chain "D" and (resid 3 through 57 or resid 60 through 213))

NCS domain segments:

Dom-ID	Component-ID	Ens-ID	Beg auth comp-ID	Beg label comp-ID	End auth comp-ID	End label comp-ID	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
d_1	1	ens_1	VAL	VAL	GLN	GLN	A	A	2 - 100	2 - 100
d_1	2	ens_1	GLY	GLY	PRO	PRO	A	A	108 - 222	108 - 222
d_2	1	ens_1	VAL	VAL	GLN	GLN	C	C	2 - 100	2 - 100
d_2	2	ens_1	GLY	GLY	PRO	PRO	C	C	108 - 135	108 - 135
d_2	3	ens_1	GLY	GLY	PRO	PRO	C	C	143 - 222	143 - 222
d_1	1	ens_2	VAL	VAL	PRO	PRO	B	B	3 - 213	3 - 213
d_2	1	ens_2	VAL	VAL	PRO	PRO	D	D	3 - 57	3 - 57
d_2	2	ens_2	VAL	VAL	PRO	PRO	D	D	60 - 213	60 - 213

NCS ensembles :

ID
ens_1
ens_2

NCS oper:

ID	Code	Matrix	Vector
1	given	(-0.992497180184, 0.108854989817, 0.0556770915051), (0.110512226648, 0.993491525363, 0.0275977678845), (-0.0523105638252, 0.0335437061603, -0.998067344767)	1.03644913573, -4.90385791909, -36.9077858336
2	given	(-0.994461746271, 0.0893928992679, 0.0552697454718), (0.0910460491201, 0.995448782753, 0.0281484964833), (-0.0525019251423, 0.0330246949288, -0.998074605118)	1.82679494419, -4.59994502285, -37.1730014588

#1: Antibody	Neutralizing monoclonal antibody Fab fragment for human leptin, heavy chain Mass: 23681.570 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Cell line (production host): HEK293F / Production host: Homo sapiens (human)
#2: Antibody	Neutralizing monoclonal antibody Fab fragment for human leptin, light chain Mass: 22933.309 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Cell line (production host): HEK293F / Production host: Homo sapiens (human)
Has protein modification	Y

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.85 Å³/Da / Density % sol: 56.91 %
Crystal grow	Temperature: 293 K / Method: vapor diffusion, hanging drop / pH: 4 Details: Fab at 25 mg/ml in 20 mM Hepes, pH 7.4, 75 mM NaCl versus 1.0 M lithium chloride, 0.1 M citrate pH 4.0, 20% (w/v) PEG 6,000.

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Data collection

Diffraction

Mean temperature: 100 K / Serial crystal experiment: N

Diffraction source

Source:

SYNCHROTRON / Site:

APS

/ Beamline: 19-ID / Wavelength: 0.97918 Å

Detector

Type: DECTRIS PILATUS3 6M / Detector: PIXEL / Date: Jun 29, 2020

Radiation

Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray

Radiation wavelength

Wavelength: 0.97918 Å / Relative weight: 1

Reflection

Resolution: 3.25→50 Å / Num. obs: 17545 / % possible obs: 100 % / Redundancy: 21.4 % / B_iso Wilson estimate: 47.74 Å² / CC_1/2: 0.68 / CC star: 0.9 / R_merge(I) obs: 0.164 / R_pim(I) all: 0.036 / R_rim(I) all: 0.168 / Net I/σ(I): 23

Reflection shell

Diffraction-ID: 1

Resolution (Å)	Redundancy (%)	R_merge(I) obs	Num. unique obs	CC_1/2	CC star	R_pim(I) all	R_rim(I) all	Χ²	% possible all
3.25-3.31	7.6	1.439	871	0.68	0.9	0.524	1.538	0.896	99.9
3.31-3.37	11.1	1.463	859	0.86	0.962	0.441	1.531	0.898	100
3.37-3.43	14	1.41	845	0.8	0.943	0.376	1.461	0.945	100
3.43-3.5	17.4	1.31	869	0.899	0.973	0.315	1.348	1.001	100
3.5-3.58	20	1.105	839	0.916	0.978	0.249	1.133	0.917	100
3.58-3.66	21.6	1.002	874	0.931	0.982	0.218	1.026	0.995	100
3.66-3.75	22.8	0.889	849	0.942	0.985	0.188	0.91	1.026	100
3.75-3.85	23.2	0.709	877	0.961	0.99	0.149	0.725	0.912	100
3.85-3.97	22.6	0.629	853	0.971	0.993	0.134	0.643	1.218	100
3.97-4.09	21.8	0.398	862	0.983	0.996	0.086	0.408	0.907	100
4.09-4.24	25.7	0.314	876	0.991	0.998	0.063	0.32	0.906	100
4.24-4.41	25.5	0.223	877	0.996	0.999	0.045	0.228	0.941	100
4.41-4.61	25.4	0.201	873	0.994	0.999	0.04	0.206	0.94	100
4.61-4.85	25.1	0.174	869	0.995	0.999	0.035	0.178	0.948	100
4.85-5.16	24.6	0.151	863	0.997	0.999	0.031	0.154	0.928	100
5.16-5.56	23.3	0.142	891	0.995	0.999	0.03	0.145	0.898	100
5.56-6.11	25.8	0.132	894	0.996	0.999	0.026	0.135	0.849	100
6.11-7	25.2	0.109	898	0.997	0.999	0.022	0.111	0.803	100
7-8.81	22.8	0.071	922	0.999	1	0.015	0.073	0.719	100
8.81-50	22.2	0.061	984	0.996	0.999	0.014	0.062	0.737	100

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Processing

Software

Name	Version	Classification
PHENIX	1.21.2_5419	refinement
HKL-3000		data scaling
PHASER		phasing
PDB_EXTRACT		data extraction
HKL-3000		data reduction

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT / Resolution: 3.3→49.33 Å / SU ML: 0.4782 / Cross valid method: FREE R-VALUE / σ(F): 1.37 / Phase error: 32.0181
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2

	R_factor	Num. reflection	% reflection
R_free	0.3195	1576	10.05 %
R_work	0.2674	14107	-
obs	0.2726	15683	93.89 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL

Displacement parameters

B_iso mean: 61.28 Å²

Refinement step

Cycle: LAST / Resolution: 3.3→49.33 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	6250	0	0	0	6250

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.0022	6400
X-RAY DIFFRACTION	f_angle_d	0.5364	8718
X-RAY DIFFRACTION	f_chiral_restr	0.0463	984
X-RAY DIFFRACTION	f_plane_restr	0.0053	1114
X-RAY DIFFRACTION	f_dihedral_angle_d	11.8015	2258

Refine LS restraints NCS

Ens-ID	Dom-ID	Asym-ID	Auth asym-ID	Refine-ID	Type	Rms dev position (Å)
ens_1	d_2	A	A	X-RAY DIFFRACTION	Torsion NCS	0.71430244615
ens_2	d_2	B	B	X-RAY DIFFRACTION	Torsion NCS	0.798700610301

LS refinement shell

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Refine-ID	% reflection obs (%)
3.3-3.41	0.3823	61	0.3157	592	X-RAY DIFFRACTION	44.73
3.41-3.53	0.3542	137	0.3017	1162	X-RAY DIFFRACTION	86.77
3.53-3.67	0.3644	145	0.2933	1349	X-RAY DIFFRACTION	99.73
3.67-3.84	0.3571	156	0.2764	1327	X-RAY DIFFRACTION	100
3.84-4.04	0.2918	144	0.2671	1360	X-RAY DIFFRACTION	100
4.04-4.29	0.2954	150	0.2433	1343	X-RAY DIFFRACTION	100
4.29-4.62	0.2792	153	0.2285	1366	X-RAY DIFFRACTION	100
4.62-5.09	0.2887	151	0.2293	1359	X-RAY DIFFRACTION	99.93
5.09-5.82	0.2868	155	0.2577	1375	X-RAY DIFFRACTION	99.93
5.82-7.33	0.3655	155	0.2996	1399	X-RAY DIFFRACTION	100
7.33-49.33	0.3246	169	0.2831	1475	X-RAY DIFFRACTION	99.7

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	0.926496456899	0.183268796819	0.0762462760984	2.04667173337	0.201559518098	1.5127204688	-0.453338193114	0.887937595928	-0.380946859421	-0.426630715115	0.0107309098863	0.110462691677	0.158960250691	-0.0581138204765	0.216329841936	0.625128148182	0.00846067047564	-0.0596509896596	0.608528415987	-0.0618388629914	0.708185500348	14.6243551067	21.3031000208	-26.5765702774
2	0.268279878221	-0.55000814965	-0.114239084423	1.54381062123	-0.208625215619	0.376170849036	0.115019332572	0.0729378284399	-0.238933016459	-0.339791463263	0.363980083	0.588688670321	-0.54650844013	-0.309291565028	-0.0999977471104	0.555249356955	0.0852132589825	-0.102476952778	0.453981594764	0.0822036563354	0.352325929957	16.2558299381	29.7756403973	-22.7839094462
3	0.535631050693	-0.0802996886559	-0.28805585929	0.388376942959	0.153985013514	0.551700886636	0.00186262123676	-0.299561397641	0.335072312996	0.489898028909	0.00597620086272	-0.0823048490164	-0.162939335671	-0.193712168546	-0.181392015148	-0.629803465901	-0.123954131824	0.450720365098	1.29347488757	0.31400326919	0.279700670972	21.4982293636	54.9362637185	-13.4355830621
4	2.18736306503	0.199425254017	-0.0920839568827	2.22288020427	0.472616445841	1.04361023194	0.00558593803709	-0.313406812922	-0.155247918969	0.245818688317	0.26224163929	0.429511049901	0.361155380176	0.350071883987	-0.0728157331979	0.420662010548	0.0355053251906	-0.0802259591076	0.364355108856	0.153084086206	0.264513924025	20.946525225	45.8690235008	-14.8702020407
5	2.33510988721	0.633969730363	1.08512937131	1.4456702377	0.215858744102	2.19212877258	0.00930125698748	-0.246014275995	0.787719456523	-0.00751790709271	-0.356697307266	0.292259061985	-0.562059862216	0.285112922491	0.163193953502	0.312926164118	-0.0746276956541	0.0292079765911	0.701457142658	0.0298561439505	0.369378498856	27.2892511297	52.5138849998	-16.5323636132
6	0.836467435008	0.386084135451	0.157832757165	0.374145492628	0.258969504115	1.03377353914	-0.354967424377	-0.226324525818	-0.440456577152	0.414192820878	0.232784759334	1.1090730274	0.200999363184	0.388067951107	0.0815229304385	0.851785573812	-0.0553588519559	0.0606569967075	0.590489765571	-0.0262382408328	1.00022188449	17.6283641802	16.1454057637	-4.08589258512
7	0.406215706231	-0.154573085348	-0.326995953532	0.0631103199202	0.12692345887	0.257482003961	-0.114568805408	0.494128792596	-0.918468221231	-0.0171101344732	-0.0392935255863	0.21921180774	0.518082698987	-0.458377623573	-0.0257890242829	1.26814077536	0.176619717615	-0.544402658339	1.56418654201	-0.286949001777	1.27881989549	28.938182675	12.3292094735	-5.27585223008
8	0.31569331131	0.286081692005	-0.148660787698	1.03662398923	-0.549674169069	0.297513418322	-0.260340221231	-0.206685775581	0.0611615172044	0.374339459493	0.139602634845	-0.39809402645	0.102046249701	-0.146074945051	-0.196044094732	1.17893117253	0.113342540492	-0.329333069234	-0.00768248812284	0.26135772526	1.52792102819	20.1617193392	10.4252876324	-0.00277053689711
9	0.484920313496	-0.710563703492	-0.8146050005	1.88357016626	0.260422265805	2.27078221756	-0.378173812542	-0.27658696209	-0.62493891528	0.239749865857	0.0684130700308	1.05559517383	0.083861163568	-0.344607247668	0.151233793263	0.550810297417	-0.0625254859252	0.109831876233	0.343881909474	-0.110251063311	0.798946958552	16.3559274236	16.5361399147	-7.98135574735
10	3.62066633479	-1.50859282092	-2.42637226201	2.71069276276	0.0240548348764	2.08781944219	-0.662648056804	-0.139246937786	-0.67731758264	-0.139904675232	-0.382596351053	0.105539972086	0.620620657998	-0.0520964565291	0.164504148301	0.512529866664	0.025977121096	-0.0222747496723	0.74003085549	0.12018206633	0.378835829969	19.5208197785	33.295433604	5.2992956293
11	0.640658793782	-0.572336151539	0.639833831723	3.78482562657	-0.840166288691	0.646340895081	0.527885674214	0.952541070307	0.357625078234	-1.20987451018	-0.402454025791	0.474093713903	-0.649859990435	-0.444023353368	-0.118345057255	0.681220953308	0.568762819083	0.233406482809	0.758066598844	0.366658613269	0.543258162165	16.6190958721	60.7840872948	-11.9088604222
12	2.59401922526	0.243190397877	-0.738905915822	2.00415021712	0.0236107535797	0.961588948763	0.166109836428	0.756836022484	0.325823513665	0.805749342581	0.00773699525537	0.262656919925	0.354206304612	-0.672097982625	-0.0552222083438	0.60314295457	-0.0756734250857	0.0300917269594	0.665517058634	0.038614882257	0.285652210957	13.8244830986	49.6192927056	-0.240878304464
13	0.944992784135	0.577563922681	0.669857165542	1.30807616563	1.024439408	0.961729168023	-0.0814189949426	0.729995347625	-0.349142242664	0.309839626117	0.36801522941	0.21645155105	0.387576342298	-0.67571396463	0.219513644386	0.520239811689	0.126019450126	0.221785223263	0.885473154307	0.0411469442621	0.374475310275	11.7381502783	47.2490692618	-2.51858589081
14	2.32615088861	0.903334153975	-1.78077994685	1.04078459464	0.341639222931	2.8458198217	0.41839838121	-0.169357766013	0.606147734566	0.218701308512	0.184384546576	0.0921228954464	-1.17540530075	-1.03506316261	0.236688275828	1.06425030665	0.196507920776	-0.137733255051	0.697539985309	-0.0027307455258	0.26617641283	10.3925396001	58.3595096242	-8.19562517407
15	2.36642329819	0.256178795954	-0.537347452831	3.05354781899	-1.18164975427	1.30056129422	0.362367372601	-0.100764242286	0.499901326827	0.318939948802	-0.20599869177	0.326355528438	-0.655290440586	-1.46306740525	-0.0382746670392	1.05467029211	0.137152619106	0.0261421101486	0.859102369196	-0.256281029593	0.3199695639	12.4713623147	57.5790866782	3.38344031275
16	1.71379397056	0.387644133897	0.755076231191	0.731407493284	1.0697650913	2.6161292864	0.0397017188611	-1.46933304525	-1.13707085184	0.203968389619	-0.223925084723	-0.472867317607	0.78430646858	-1.53162131423	-0.713853479656	0.713979203182	-0.239481890064	-0.237391954605	0.826161747964	0.458040510048	0.805402531375	-12.9626617578	18.6483743675	-11.4498568912
17	2.45587219108	-0.729658930825	0.276323487047	1.45073273094	0.755805131374	1.89941665095	-0.0420139086646	-0.229467499645	0.195914071556	0.13313846394	0.212499544021	0.237804521254	0.0952437842602	-0.628988238046	-0.0408664662995	0.133807383966	0.0383189338051	0.0288756160206	0.350021779043	0.0958271733035	0.211987932725	-18.10399144	48.5473131548	-22.0001537156
18	0.61101341916	-0.337765058784	-0.0956357952839	0.208068398203	0.116268816874	0.817549600576	-0.476761904943	0.439925210815	-0.446869235758	-0.994369276843	0.565990578769	0.0633825366875	0.120554599295	0.0661526298989	-0.0523653363068	0.803330901209	-0.143964201015	0.0690653075711	0.27266430378	0.00341096733958	1.00084493827	-17.0878943216	12.5984344417	-33.8541519554
19	0.634685625349	0.331141220304	-0.305760984736	0.305024466021	0.0517912804839	0.419866941745	-0.178202196857	-0.0688137385094	-0.687290204474	0.0665334730001	0.0668033564543	-0.719057127109	0.677311302237	0.182392222085	-0.187379208179	0.886835542872	-0.146097334277	0.00704538678324	0.236979875382	-0.164658272839	0.651592110971	-10.9171343396	17.9264862222	-32.4477396318
20	2.36795344523	0.0218292409916	-0.253147673298	2.01863725715	-0.250341935197	3.36039458252	-0.0381371791244	-0.474050897319	-0.0809787609926	0.259550449756	-0.0202312385936	-0.375707089501	0.673604915598	0.364747890629	-0.0322543455509	0.15462006146	-0.0841447527468	-0.106308228524	0.189878117979	-0.146238666022	0.163186611241	-6.49845901858	49.7703672734	-30.8544760626
21	1.36979493517	-0.739938759044	-0.23031123409	2.56153512771	0.411960032854	2.21784882162	0.196520913846	-0.0740692342237	0.360795915632	-0.963004557772	-0.173579053859	-0.52467628812	-0.247231470517	0.741981403671	-0.0381804449705	0.367517265327	-0.103448604017	0.132018497251	0.130368905605	0.259314714001	0.0991986966603	-5.57894460481	54.0987955713	-39.401465129

Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

ID	Refine TLS-ID	Selection details	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
1	1	chain 'A' and (resid 2 through 99 )	A	A	2 - 99	1 - 98
2	2	chain 'A' and (resid 100 through 128 )	A	A	100 - 128	99 - 121
3	3	chain 'A' and (resid 129 through 154 )	A	A	129 - 154	122 - 140
4	4	chain 'A' and (resid 155 through 184 )	A	A	155 - 184	141 - 170
5	5	chain 'A' and (resid 185 through 222 )	A	A	185 - 222	171 - 208
6	6	chain 'B' and (resid 3 through 50 )	B	B	3 - 50	1 - 48
7	7	chain 'B' and (resid 51 through 63 )	B	B	51 - 63	49 - 59
8	8	chain 'B' and (resid 64 through 77 )	B	B	64 - 77	60 - 73
9	9	chain 'B' and (resid 78 through 105 )	B	B	78 - 105	74 - 101
10	10	chain 'B' and (resid 106 through 118 )	B	B	106 - 118	102 - 112
11	11	chain 'B' and (resid 119 through 134 )	B	B	119 - 134	113 - 128
12	12	chain 'B' and (resid 135 through 155 )	B	B	135 - 155	129 - 149
13	13	chain 'B' and (resid 156 through 176 )	B	B	156 - 176	150 - 170
14	14	chain 'B' and (resid 177 through 192 )	B	B	177 - 192	171 - 186
15	15	chain 'B' and (resid 193 through 213 )	B	B	193 - 213	187 - 207
16	16	chain 'C' and (resid 2 through 128 )	C	C	2 - 128	1 - 122
17	17	chain 'C' and (resid 129 through 223 )	C	C	129 - 223	123 - 217
18	18	chain 'D' and (resid 2 through 94 )	D	D	2 - 94	1 - 93
19	19	chain 'D' and (resid 95 through 118 )	D	D	95 - 118	94 - 115
20	20	chain 'D' and (resid 119 through 192 )	D	D	119 - 192	116 - 189
21	21	chain 'D' and (resid 193 through 213 )	D	D	193 - 213	190 - 210

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