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TitleLeptin as a key driver for organ fibrogenesis.
Journal, issue, pagesSci Adv, Vol. 11, Page eady7904-eady7904, Year 2025
Publish dateJul 31, 2025 (structure data deposition date)
AuthorsSun, X.N. / Chen, S. / Zhao, S. / Funcke, J.B. / Virostek, M. / Pedersen, L. / Li, C. / Joung, C. / Lin, Q. / Li, Y. ...Sun, X.N. / Chen, S. / Zhao, S. / Funcke, J.B. / Virostek, M. / Pedersen, L. / Li, C. / Joung, C. / Lin, Q. / Li, Y. / Cobb, A. / Wang, M.Y. / Min, K. / Maya-Ramos, L. / Degasperi, G. / Liu, J. / Zhang, N. / An, Z. / Tomchick, D.R. / Wynn, R.M. / Oh, D.Y. / Scherer, P.E.
External linksSci Adv / PubMed:41124259
MethodsX-ray diffraction
Resolution3.1 - 3.3 Å
Structure data

PDB-9puk:
Neutralizing monoclonal antibody Fab fragment for human leptin
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-9puo:
Neutralizing monoclonal antibody Fab fragment bound to leptin
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody / FAB / leptin

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