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- PDB-9nmx: TCR156 S32Malpha variant bound to HLA A*02:01-PAP -

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Basic information

Entry
Database: PDB / ID: 9nmx
TitleTCR156 S32Malpha variant bound to HLA A*02:01-PAP
Components
  • Beta-2-microglobulin
  • HLA class I histocompatibility antigen, A alpha chain
  • Prostatic acid phosphatase
  • TCR156 alpha chain S32M extracellular domains
  • TCR156 beta chain extracellular domains
KeywordsIMMUNE SYSTEM / complex / TCR
Function / homology
Function and homology information


thiamine phosphate phosphatase activity / positive regulation of adenosine receptor signaling pathway / thiamine metabolic process / Golgi cisterna / adenosine metabolic process / acid phosphatase / regulation of sensory perception of pain / acid phosphatase activity / lysophosphatidic acid phosphatase activity / 5'-nucleotidase ...thiamine phosphate phosphatase activity / positive regulation of adenosine receptor signaling pathway / thiamine metabolic process / Golgi cisterna / adenosine metabolic process / acid phosphatase / regulation of sensory perception of pain / acid phosphatase activity / lysophosphatidic acid phosphatase activity / 5'-nucleotidase / 5'-nucleotidase activity / choline binding / nucleotide metabolic process / vesicle membrane / azurophil granule membrane / purine nucleobase metabolic process / phosphatase activity / antigen processing and presentation of peptide antigen via MHC class I / multivesicular body / protein-tyrosine-phosphatase / protein tyrosine phosphatase activity / early endosome lumen / Nef mediated downregulation of MHC class I complex cell surface expression / DAP12 interactions / Endosomal/Vacuolar pathway / T cell mediated cytotoxicity / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / filopodium / lipid metabolic process / lumenal side of endoplasmic reticulum membrane / regulation of iron ion transport / cellular response to iron(III) ion / negative regulation of iron ion transport / negative regulation of forebrain neuron differentiation / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / ER to Golgi transport vesicle membrane / peptide antigen assembly with MHC class I protein complex / regulation of erythrocyte differentiation / response to molecule of bacterial origin / HFE-transferrin receptor complex / transferrin transport / MHC class I peptide loading complex / cellular response to iron ion / negative regulation of receptor-mediated endocytosis / positive regulation of T cell cytokine production / antigen processing and presentation of endogenous peptide antigen via MHC class I / MHC class I protein complex / peptide antigen assembly with MHC class II protein complex / negative regulation of neurogenesis / cellular response to nicotine / positive regulation of receptor-mediated endocytosis / MHC class II protein complex / multicellular organismal-level iron ion homeostasis / positive regulation of T cell mediated cytotoxicity / specific granule lumen / positive regulation of immune response / antigen processing and presentation of exogenous peptide antigen via MHC class II / peptide antigen binding / phagocytic vesicle membrane / recycling endosome membrane / Interferon gamma signaling / negative regulation of epithelial cell proliferation / positive regulation of T cell activation / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / apical part of cell / Modulation by Mtb of host immune system / sensory perception of smell / positive regulation of cellular senescence / tertiary granule lumen / DAP12 signaling / MHC class II protein complex binding / T cell differentiation in thymus / late endosome membrane / negative regulation of neuron projection development / ER-Phagosome pathway / protein refolding / early endosome membrane / molecular adaptor activity / amyloid fibril formation / protein homotetramerization / intracellular iron ion homeostasis / learning or memory / endoplasmic reticulum lumen / Amyloid fiber formation / Golgi membrane / external side of plasma membrane / lysosomal membrane / focal adhesion / Neutrophil degranulation / SARS-CoV-2 activates/modulates innate and adaptive immune responses / structural molecule activity / endoplasmic reticulum / Golgi apparatus / protein homodimerization activity / : / extracellular exosome / extracellular region / membrane / identical protein binding / nucleus
Similarity search - Function
Histidine acid phosphatases active site signature. / : / Histidine acid phosphatases phosphohistidine signature. / Histidine acid phosphatase active site / Histidine phosphatase superfamily, clade-2 / Histidine phosphatase superfamily (branch 2) / Histidine phosphatase superfamily / MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Beta-2-Microglobulin ...Histidine acid phosphatases active site signature. / : / Histidine acid phosphatases phosphohistidine signature. / Histidine acid phosphatase active site / Histidine phosphatase superfamily, clade-2 / Histidine phosphatase superfamily (branch 2) / Histidine phosphatase superfamily / MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Beta-2-Microglobulin / : / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
MALONATE ION / MHC class I antigen / Prostatic acid phosphatase / Beta-2-microglobulin
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.19 Å
AuthorsJude, K.M. / Chen, X. / Garcia, K.C.
Funding support United States, 1items
OrganizationGrant numberCountry
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)5 R01 AI103867 08 United States
CitationJournal: To Be Published
Title: T cell receptor catch bond engineering enhances T cell function and killing of prostate cancer
Authors: Chen, X. / Jude, K.M. / Garcia, K.C.
History
DepositionMar 4, 2025Deposition site: RCSB / Processing site: RCSB
Revision 1.0Mar 18, 2026Provider: repository / Type: Initial release

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: HLA class I histocompatibility antigen, A alpha chain
B: Beta-2-microglobulin
C: Prostatic acid phosphatase
D: TCR156 alpha chain S32M extracellular domains
E: TCR156 beta chain extracellular domains
hetero molecules


Theoretical massNumber of molelcules
Total (without water)109,89323
Polymers107,8975
Non-polymers1,99618
Water3,981221
1


  • Idetical with deposited unit
  • defined by author&software
  • Evidence: surface plasmon resonance
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area15260 Å2
ΔGint-48 kcal/mol
Surface area36910 Å2
MethodPISA
Unit cell
Length a, b, c (Å)225.956, 46.307, 91.793
Angle α, β, γ (deg.)90.000, 95.126, 90.000
Int Tables number5
Space group name H-MC121
Space group name HallC2y
Symmetry operation#1: x,y,z
#2: -x,y,-z
#3: x+1/2,y+1/2,z
#4: -x+1/2,y+1/2,-z

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Components

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Protein , 4 types, 4 molecules ABDE

#1: Protein HLA class I histocompatibility antigen, A alpha chain / HLA A*02:01


Mass: 32256.670 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: HLA-A / Production host: Escherichia coli (E. coli) / References: UniProt: A5I8L1
#2: Protein Beta-2-microglobulin


Mass: 11879.356 Da / Num. of mol.: 1 / Fragment: UNP residues 21-119
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: B2M, CDABP0092, HDCMA22P / Production host: Escherichia coli (E. coli) / References: UniProt: P61769
#4: Protein TCR156 alpha chain S32M extracellular domains


Mass: 28305.717 Da / Num. of mol.: 1 / Mutation: S32M
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli)
#5: Protein TCR156 beta chain extracellular domains


Mass: 34474.125 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli)

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Protein/peptide / Sugars , 2 types, 4 molecules C

#3: Protein/peptide Prostatic acid phosphatase / PAP / 5'-nucleotidase / 5'-NT / Acid phosphatase 3 / Ecto-5'-nucleotidase / Protein tyrosine ...PAP / 5'-nucleotidase / 5'-NT / Acid phosphatase 3 / Ecto-5'-nucleotidase / Protein tyrosine phosphatase ACP3 / Thiamine monophosphatase / TMPase


Mass: 981.188 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: ACP3, ACPP / Production host: synthetic construct (others)
References: UniProt: P15309, acid phosphatase, 5'-nucleotidase, protein-tyrosine-phosphatase
#9: Sugar ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Non-polymers , 4 types, 236 molecules

#6: Chemical ChemComp-MLI / MALONATE ION


Mass: 102.046 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C3H2O4
#7: Chemical
ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL


Mass: 92.094 Da / Num. of mol.: 12 / Source method: obtained synthetically / Formula: C3H8O3
#8: Chemical ChemComp-NA / SODIUM ION


Mass: 22.990 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: Na
#10: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 221 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestN
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.22 Å3/Da / Density % sol: 44.51 %
Crystal growTemperature: 295 K / Method: vapor diffusion / pH: 7.5
Details: 0.2 M Sodium malonate, 0.1 M bis Tris-propane pH 7.5, 17% PEG 3500

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: ALS / Beamline: 8.2.1 / Wavelength: 1 Å
DetectorType: DECTRIS EIGER2 S 9M / Detector: PIXEL / Date: Apr 10, 2024
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1 Å / Relative weight: 1
ReflectionResolution: 2.19→46.11 Å / Num. obs: 48631 / % possible obs: 98.48 % / Redundancy: 3.4 % / Biso Wilson estimate: 46.83 Å2 / CC1/2: 0.997 / Rmerge(I) obs: 0.0916 / Rpim(I) all: 0.0583 / Rrim(I) all: 0.109 / Net I/σ(I): 9.32
Reflection shellResolution: 2.19→2.24 Å / Redundancy: 3.5 % / Rmerge(I) obs: 1.49 / Mean I/σ(I) obs: 0.76 / Num. unique obs: 3455 / CC1/2: 0.362 / Rpim(I) all: 0.929 / Rrim(I) all: 1.758 / % possible all: 99.45

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Processing

Software
NameVersionClassification
PHENIX1.21.1_5286refinement
XDSdata reduction
XDSdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.19→46.11 Å / SU ML: 0.2979 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 25.0249
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2291 2000 4.11 %
Rwork0.1932 46610 -
obs0.1947 48610 98.48 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 63.38 Å2
Refinement stepCycle: LAST / Resolution: 2.19→46.11 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6593 0 129 221 6943
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00346927
X-RAY DIFFRACTIONf_angle_d0.55929387
X-RAY DIFFRACTIONf_chiral_restr0.0411985
X-RAY DIFFRACTIONf_plane_restr0.00451227
X-RAY DIFFRACTIONf_dihedral_angle_d12.50992584
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.19-2.240.32551420.31283308X-RAY DIFFRACTION99.45
2.24-2.310.32541430.30963329X-RAY DIFFRACTION99.4
2.31-2.370.32691430.30113322X-RAY DIFFRACTION99.54
2.37-2.450.30181410.27863306X-RAY DIFFRACTION97.59
2.45-2.540.30151380.25813191X-RAY DIFFRACTION96.77
2.54-2.640.32591390.25043261X-RAY DIFFRACTION96.95
2.64-2.760.29961450.24373368X-RAY DIFFRACTION99.72
2.76-2.90.28511430.23943347X-RAY DIFFRACTION99.46
2.9-3.090.26891450.21273378X-RAY DIFFRACTION99.49
3.09-3.320.21451430.19143336X-RAY DIFFRACTION99.23
3.33-3.660.22271440.18043345X-RAY DIFFRACTION98.98
3.66-4.190.18841440.1533369X-RAY DIFFRACTION98.6
4.19-5.270.17891400.14133243X-RAY DIFFRACTION94.97
5.28-46.110.19791500.17793507X-RAY DIFFRACTION98.68
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
14.26810651991-0.596699500057-2.456399690992.73355428744-1.43028217727.77253783617-0.1271536420160.401722810295-0.241217433857-0.25634379182-0.05038700148310.05351742950820.538457104187-0.165565281680.2098806767760.257254017289-0.02632308744590.01265026020920.25139143259-0.06389960035360.358619925957-42.4627386709-9.37805976077-9.70110660327
21.511006510070.05763164037320.58741159341.29459921634-0.2518406601032.27955749391-0.03432462559470.1978950562230.22363430697-0.195600253988-0.104042954828-0.3318926968690.03217825452590.1204224401880.1448246499960.275640180057-0.009316476550390.06141225576810.2674959940330.05108359025370.400950567793-38.34524085151.2892348312-6.97614810084
33.43847929153-1.058993106221.659902656395.38149776246-2.372181454524.9907990387-0.01885523123350.8972078055430.899935848552-0.1027518323760.2749436804720.320849477991-1.25648375814-0.0896994061362-0.1505442400220.9392732497750.0228213406960.1335824007510.6747348000040.2627205854480.583358318393-51.512903702912.0421079911-33.9485406801
43.250168276911.074849172211.233125018154.680890021341.192490221264.81909992522-0.1380850626790.33588373061-0.0112118821198-0.5581254133420.03570485554470.04992899620810.166927693602-0.2234753991740.1367702462070.2890322022170.00626893108680.02042739671170.3630099259510.02153534639810.285049338206-58.4877093956-3.00832910627-20.1012468973
52.42520596657-4.453457200822.319428322678.17813769672-4.25735681982.215807981790.1396077269330.520491856596-1.04635730835-0.5752780882370.7566696707571.193948838920.656046451375-1.28122214887-0.9520515173330.641454228768-0.324658372587-0.1884597347911.013051625090.1584795436860.617946242109-69.9398460164-12.7902344004-21.5433749142
63.278250244283.506193644545.53664734327.01662892566.333363024889.295824356830.2122944879740.142201166297-0.463223710006-0.03008455882310.271406924804-0.6454611809310.3854350233220.0612566208991-0.6024491963950.3236746479750.01304910613920.06018736899360.2947929111310.07948409371260.384660633225-51.4293463184-4.46635677926-13.4785507085
76.996034371752.541240084443.348541084976.142795963013.884407339015.19618210217-0.3509117605730.990424376689-0.450457515464-1.237224045270.3183940492920.116879534309-0.377938981533-0.2053138851110.05049413124020.594967936636-0.1034307907780.004312929608070.4789408223460.03830999896640.346303662368-60.6875024852-8.31023844424-25.4770532165
84.049483379580.01366442268220.1121570214034.733594284263.509190947112.59546110784-0.07987200280590.6495757071460.255099092827-0.689054689014-0.2027456388880.363730264152-0.093712036241-0.8600613478270.2594201760830.4494734466680.0182157677614-0.08493152126880.5651505293540.1417041890680.454857364748-66.034000677-1.02793289083-19.6118326632
93.96974944089-1.33040433559-0.6779417498121.52510112623-0.09185671493820.2246985116210.107202460876-0.1918266359580.567702059645-0.04137480525210.127095167099-0.589668599187-0.02572698908320.085704152179-0.112268033920.297233958874-0.01990759173760.009979576993330.3055756958030.02687002934230.441290975991-33.7083776751-4.322102322230.625496408067
104.82828182703-0.6323950074665.022214546592.49029460188-0.3805710596475.238919504420.8851951820540.906389002445-1.52343386622-0.128623955184-0.136854867281-0.9485137431971.486553558160.549577440299-0.8055422281140.5455815990050.02389746237480.0009335524583360.500504677079-0.09863911223450.584022153131-6.81339465029-17.95987380943.74792272462
113.771955002840.509348776227-0.1876853385531.1229019742-0.2035459105191.621443373480.1050042808520.06069700976220.1857296613940.0421239355887-0.03956439931460.07869381803830.1116019296570.0838229337028-0.03008315319820.2589585873970.0365989098240.03320394313180.300579024707-0.05550549890510.358414116758-13.6858270118-9.233504876885.09899491807
124.66387697451.010403981226.338908194591.605371476651.055415409428.7021918403-0.002060021541730.206380162364-0.0358418106787-0.08863610519760.258932497615-0.0965747534853-0.7830427899430.0665885720124-0.2255594209940.3250153862930.007171138643310.04256075485030.394723029052-0.02246414595050.537489930787-8.96425036172-1.242708931931.62396835227
135.359504660230.5578818496860.2968976184421.40376018994-1.353943983841.71872809919-0.104398463565-0.1337717717790.137574162395-0.0829041458633-0.07183108457480.0383638791442-0.0247361256788-0.04379385045420.1927604868910.3315237039350.02963507935440.03917563354090.324827063013-0.05498511414880.320582061285-11.2452054907-9.794703022534.55977555929
144.08398469406-2.872984999323.487425832813.14861668816-1.550962876646.0820934601-0.619262115628-0.190038906475-0.7135572568590.1276051557470.00234533972137-1.09770346875-0.6455253916411.014273714340.4271635438460.39958737242-0.0316031561264-0.01531054420710.6328000049140.1734987157310.5185600838776.03752843269-13.838910479214.7060133895
155.51120885367-0.862172581986-3.442897079183.214944109582.587795368373.55917260136-0.810037423493-1.02711308772-0.799321193540.552844935949-0.507831129707-1.309727801771.00106840720.946004263061.345246320630.8108631811890.140006304322-0.1628005244180.9242361877950.2922524101670.93815976338311.3971113499-27.044047155238.2677297321
166.972724459021.798917077430.1505879066578.48354538465-0.1178136376187.11474039105-0.402903442688-0.0697749552859-0.870968931691-0.721313176134-0.0287396199459-0.6250363089870.3143688192030.4744285337920.447627241680.4344296389860.04268891640930.09629860860510.5357397175710.1381046982540.5282624753948.81222734614-21.204907699823.8520565694
177.79320962420.8160447903271.387659372425.320894484971.592849219925.78630337885-0.02847810480920.427773063353-1.86199551761-0.41647939199-0.501841628564-1.134282766550.8764406873661.298534363180.6071316966810.8467621793320.2885101686170.1764550344920.9360556591120.27318295541.3063491824816.9419957685-30.082810943625.5835709792
184.14144275576-1.600184481891.529510391694.70236623356-1.839462739214.052457994210.185233329043-0.355001899281-0.2627843337090.1522359035560.0005558867229350.1579906589480.313456440114-0.0595146041918-0.1687905811820.312613450939-0.06706603337910.02365520161890.256323572801-0.0225229250430.299204985969-28.274988189-19.60501771116.4766691724
195.37921959582-2.774219297975.267834261911.43062151119-2.720471418445.180265665190.726254238788-0.447419993753-1.011109843840.126323564405-0.2785656008380.2535220667061.02558188117-0.0370436525119-0.4152136222360.847524783558-0.123334736931-0.09594122797080.5264301346180.2148594309210.602302277899-16.8760967839-33.198895851728.8459708178
204.181792716871.47785605563-0.3723095987484.65254502108-0.8918561158424.74994541053-0.141122574424-0.356826229088-0.2431339282090.0378477344058-0.212262132479-0.645142692432-0.1715721533750.6862279965540.3470087058950.5120424778830.0372289540358-0.07780541728090.5396104568590.1492686696770.3916467528141.7896996126-21.079957167632.310118408
219.170784023163.944952528523.370369045595.643983791811.678057205793.872064947270.0407939780078-0.802256698884-0.03992601206730.621053656235-0.2666184619060.0876458207044-0.1394618186340.2687366440670.1998676844190.6058942152320.01429638493660.01754993815780.7545169123190.1191555572890.256546951956-7.56642780606-23.466766845840.8667572397
Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

IDRefine TLS-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
11chain 'A' and (resid 1 through 56 )AA1 - 561 - 56
22chain 'A' and (resid 57 through 197 )AA57 - 19757 - 197
33chain 'A' and (resid 198 through 276 )AA198 - 276198 - 276
44chain 'B' and (resid 0 through 41 )BD0 - 411 - 42
55chain 'B' and (resid 42 through 46 )BD42 - 4643 - 47
66chain 'B' and (resid 47 through 61 )BD47 - 6148 - 62
77chain 'B' and (resid 62 through 77 )BD62 - 7763 - 78
88chain 'B' and (resid 78 through 99 )BD78 - 9979 - 100
99chain 'C' and (resid 1 through 9 )CG1 - 91 - 9
1010chain 'D' and (resid 2 through 14 )DH2 - 141 - 13
1111chain 'D' and (resid 15 through 53 )DH15 - 5314 - 52
1212chain 'D' and (resid 54 through 66 )DH54 - 6653 - 65
1313chain 'D' and (resid 67 through 98 )DH67 - 9866 - 97
1414chain 'D' and (resid 99 through 115 )DH99 - 11598 - 114
1515chain 'D' and (resid 116 through 128 )DH116 - 128115 - 127
1616chain 'D' and (resid 129 through 173 )DH129 - 173128 - 172
1717chain 'D' and (resid 174 through 198 )DH174 - 198173 - 197
1818chain 'E' and (resid 3 through 106 )EL3 - 1061 - 104
1919chain 'E' and (resid 107 through 121 )EL107 - 121105 - 119
2020chain 'E' and (resid 122 through 199 )EL122 - 199120 - 197
2121chain 'E' and (resid 200 through 242 )EL200 - 242198 - 240

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