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- PDB-9nmw: TCR156 S30Ealpha S32Qalpha bound to HLA A*02:01-PAP -

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Basic information

Entry
Database: PDB / ID: 9nmw
TitleTCR156 S30Ealpha S32Qalpha bound to HLA A*02:01-PAP
Components
  • Beta-2-microglobulin
  • HLA class I histocompatibility antigen, A alpha chain
  • Prostatic acid phosphatase
  • TCR156 alpha chain S30E S32Q
  • TCR156 beta chain
KeywordsIMMUNE SYSTEM / complex / TCR
Function / homology
Function and homology information


thiamine phosphate phosphatase activity / positive regulation of adenosine receptor signaling pathway / thiamine metabolic process / Golgi cisterna / adenosine metabolic process / acid phosphatase / regulation of sensory perception of pain / acid phosphatase activity / lysophosphatidic acid phosphatase activity / 5'-nucleotidase ...thiamine phosphate phosphatase activity / positive regulation of adenosine receptor signaling pathway / thiamine metabolic process / Golgi cisterna / adenosine metabolic process / acid phosphatase / regulation of sensory perception of pain / acid phosphatase activity / lysophosphatidic acid phosphatase activity / 5'-nucleotidase / 5'-nucleotidase activity / choline binding / nucleotide metabolic process / vesicle membrane / azurophil granule membrane / purine nucleobase metabolic process / phosphatase activity / antigen processing and presentation of peptide antigen via MHC class I / multivesicular body / protein-tyrosine-phosphatase / protein tyrosine phosphatase activity / early endosome lumen / Nef mediated downregulation of MHC class I complex cell surface expression / DAP12 interactions / Endosomal/Vacuolar pathway / T cell mediated cytotoxicity / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / filopodium / lipid metabolic process / lumenal side of endoplasmic reticulum membrane / regulation of iron ion transport / cellular response to iron(III) ion / negative regulation of iron ion transport / negative regulation of forebrain neuron differentiation / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / ER to Golgi transport vesicle membrane / peptide antigen assembly with MHC class I protein complex / regulation of erythrocyte differentiation / response to molecule of bacterial origin / HFE-transferrin receptor complex / transferrin transport / MHC class I peptide loading complex / cellular response to iron ion / negative regulation of receptor-mediated endocytosis / positive regulation of T cell cytokine production / antigen processing and presentation of endogenous peptide antigen via MHC class I / MHC class I protein complex / peptide antigen assembly with MHC class II protein complex / negative regulation of neurogenesis / cellular response to nicotine / positive regulation of receptor-mediated endocytosis / MHC class II protein complex / multicellular organismal-level iron ion homeostasis / positive regulation of T cell mediated cytotoxicity / specific granule lumen / positive regulation of immune response / antigen processing and presentation of exogenous peptide antigen via MHC class II / peptide antigen binding / phagocytic vesicle membrane / recycling endosome membrane / Interferon gamma signaling / negative regulation of epithelial cell proliferation / positive regulation of T cell activation / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / apical part of cell / Modulation by Mtb of host immune system / sensory perception of smell / positive regulation of cellular senescence / tertiary granule lumen / DAP12 signaling / MHC class II protein complex binding / T cell differentiation in thymus / late endosome membrane / negative regulation of neuron projection development / ER-Phagosome pathway / protein refolding / early endosome membrane / molecular adaptor activity / amyloid fibril formation / protein homotetramerization / intracellular iron ion homeostasis / learning or memory / endoplasmic reticulum lumen / Amyloid fiber formation / Golgi membrane / external side of plasma membrane / lysosomal membrane / focal adhesion / Neutrophil degranulation / SARS-CoV-2 activates/modulates innate and adaptive immune responses / structural molecule activity / endoplasmic reticulum / Golgi apparatus / protein homodimerization activity / : / extracellular exosome / extracellular region / membrane / identical protein binding / nucleus
Similarity search - Function
Histidine acid phosphatases active site signature. / : / Histidine acid phosphatases phosphohistidine signature. / Histidine acid phosphatase active site / Histidine phosphatase superfamily, clade-2 / Histidine phosphatase superfamily (branch 2) / Histidine phosphatase superfamily / MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Beta-2-Microglobulin ...Histidine acid phosphatases active site signature. / : / Histidine acid phosphatases phosphohistidine signature. / Histidine acid phosphatase active site / Histidine phosphatase superfamily, clade-2 / Histidine phosphatase superfamily (branch 2) / Histidine phosphatase superfamily / MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Beta-2-Microglobulin / : / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
MHC class I antigen / Prostatic acid phosphatase / Beta-2-microglobulin
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.11 Å
AuthorsJude, K.M. / Chen, X. / Garcia, K.C.
Funding support United States, 1items
OrganizationGrant numberCountry
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)5 R01 AI103867 08 United States
CitationJournal: To Be Published
Title: T cell receptor catch bond engineering enhances T cell function and killing of prostate cancer
Authors: Chen, X. / Jude, K.M. / Garcia, K.C.
History
DepositionMar 4, 2025Deposition site: RCSB / Processing site: RCSB
Revision 1.0Mar 18, 2026Provider: repository / Type: Initial release

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: HLA class I histocompatibility antigen, A alpha chain
B: Beta-2-microglobulin
C: Prostatic acid phosphatase
D: TCR156 alpha chain S30E S32Q
E: TCR156 beta chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)109,70920
Polymers107,9365
Non-polymers1,77315
Water3,063170
1


  • Idetical with deposited unit
  • defined by author
  • Evidence: surface plasmon resonance
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)226.008, 46.635, 92.552
Angle α, β, γ (deg.)90.000, 96.076, 90.000
Int Tables number5
Space group name H-MC121
Space group name HallC2y
Symmetry operation#1: x,y,z
#2: -x,y,-z
#3: x+1/2,y+1/2,z
#4: -x+1/2,y+1/2,-z
Components on special symmetry positions
IDModelComponents
11D-305-

SO4

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Components

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Protein , 4 types, 4 molecules ABDE

#1: Protein HLA class I histocompatibility antigen, A alpha chain / HLA A*02:01


Mass: 32256.670 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: HLA-A / Production host: Escherichia coli (E. coli) / References: UniProt: A5I8L1
#2: Protein Beta-2-microglobulin


Mass: 11879.356 Da / Num. of mol.: 1 / Fragment: UNP residues 21-119
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: B2M, CDABP0092, HDCMA22P / Production host: Escherichia coli (E. coli) / References: UniProt: P61769
#4: Protein TCR156 alpha chain S30E S32Q


Mass: 28344.686 Da / Num. of mol.: 1 / Mutation: S30E, S32Q
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli)
#5: Protein TCR156 beta chain


Mass: 34474.125 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli)

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Protein/peptide / Sugars , 2 types, 4 molecules C

#3: Protein/peptide Prostatic acid phosphatase / PAP / 5'-nucleotidase / 5'-NT / Acid phosphatase 3 / Ecto-5'-nucleotidase / Protein tyrosine ...PAP / 5'-nucleotidase / 5'-NT / Acid phosphatase 3 / Ecto-5'-nucleotidase / Protein tyrosine phosphatase ACP3 / Thiamine monophosphatase / TMPase


Mass: 981.188 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: ACP3, ACPP / Production host: synthetic construct (others)
References: UniProt: P15309, acid phosphatase, 5'-nucleotidase, protein-tyrosine-phosphatase
#7: Sugar ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Non-polymers , 3 types, 182 molecules

#6: Chemical
ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL


Mass: 92.094 Da / Num. of mol.: 11 / Source method: obtained synthetically / Formula: C3H8O3
#8: Chemical ChemComp-SO4 / SULFATE ION


Mass: 96.063 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: SO4
#9: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 170 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestN
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.25 Å3/Da / Density % sol: 45.25 %
Crystal growTemperature: 295 K / Method: vapor diffusion / pH: 7.5
Details: 0.2 M Na2SO4, bis tris propane pH 7.5, 20% PEG 3350

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: ALS / Beamline: 8.2.1 / Wavelength: 1 Å
DetectorType: DECTRIS EIGER2 S 9M / Detector: PIXEL / Date: Apr 10, 2024
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1 Å / Relative weight: 1
ReflectionResolution: 2.11→46.02 Å / Num. obs: 55203 / % possible obs: 98.73 % / Redundancy: 3.5 % / Biso Wilson estimate: 49.24 Å2 / CC1/2: 0.998 / Rmerge(I) obs: 0.0752 / Rpim(I) all: 0.04761 / Rrim(I) all: 0.08935 / Net I/σ(I): 10.1
Reflection shellResolution: 2.11→2.15 Å / Redundancy: 3.6 % / Rmerge(I) obs: 1.81 / Mean I/σ(I) obs: 0.57 / Num. unique obs: 3202 / CC1/2: 0.35 / Rpim(I) all: 1.12 / Rrim(I) all: 2.135 / % possible all: 98.52

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Processing

Software
NameVersionClassification
PHENIX1.21.2_5419refinement
XDSdata reduction
XDSdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.11→46.02 Å / SU ML: 0.3493 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 29.0954
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflectionSelection details
Rfree0.2324 2407 4.36 %random
Rwork0.1942 52756 --
obs0.1959 55163 98.73 %-
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 69.29 Å2
Refinement stepCycle: LAST / Resolution: 2.11→46.02 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6603 0 113 170 6886
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00346899
X-RAY DIFFRACTIONf_angle_d0.59169349
X-RAY DIFFRACTIONf_chiral_restr0.0418982
X-RAY DIFFRACTIONf_plane_restr0.00461220
X-RAY DIFFRACTIONf_dihedral_angle_d14.7052573
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.11-2.150.41961390.37263052X-RAY DIFFRACTION98.61
2.15-2.20.36091400.35873061X-RAY DIFFRACTION98.8
2.2-2.250.35991410.3283097X-RAY DIFFRACTION99.29
2.25-2.310.36741440.3113122X-RAY DIFFRACTION99.39
2.31-2.370.35961370.30423036X-RAY DIFFRACTION98.79
2.37-2.440.30961400.283066X-RAY DIFFRACTION98.19
2.44-2.520.29781390.25553050X-RAY DIFFRACTION97.85
2.52-2.610.26491400.24793035X-RAY DIFFRACTION96.21
2.61-2.710.27971410.23393112X-RAY DIFFRACTION99.72
2.71-2.840.241410.23073100X-RAY DIFFRACTION99.78
2.84-2.990.31571450.21943158X-RAY DIFFRACTION99.94
2.99-3.170.26691420.20173130X-RAY DIFFRACTION99.73
3.17-3.420.23371430.19113124X-RAY DIFFRACTION99.21
3.42-3.760.1971430.16973123X-RAY DIFFRACTION99.27
3.76-4.310.18331440.15043158X-RAY DIFFRACTION98.89
4.31-5.420.17331380.14113056X-RAY DIFFRACTION96
5.42-46.020.21421500.17573276X-RAY DIFFRACTION98.87
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
13.02427085279-0.902645261463-0.09152002212051.86746315104-0.01651873814362.47664716170.04752612812060.185732301077-0.270159626965-0.108852577469-0.03451589747460.005694200300260.3433631216230.08421675669370.00228001587970.443908602458-0.01258257072780.003631141348370.385105677587-0.0540014788340.445018898381-41.5695630703-6.20522688673-6.08752450556
21.908231361780.1806229683310.9090180381070.8146936690530.1019947608582.24190464069-0.0913476849450.2234328782540.371573842936-0.222684797316-0.0583136389677-0.17690912236-0.1082105965030.3127765626770.1081488628550.437070516244-0.01241164209170.03900274449810.3348254740030.06660502835920.516655781703-38.23175450527.1877393547-9.54922505646
31.75174849714-0.04894728751280.6355543407961.768029833690.27972590572.30045659248-0.02709198563030.6505748666110.787414399825-0.4553091728110.1334224081850.113504334938-0.6278657949190.128259947117-0.1412958380890.913127439945-0.0446029390230.05486583815740.7880362601430.293886749920.748248077123-51.380738918315.1782439083-33.9522006579
45.718353703771.989516144153.330539921814.897864633862.911649111439.7752846426-0.327349531538-0.2486254130870.9535026339080.44352310135-0.352904830809-0.164965789801-0.3758923081080.1821385461980.3631550807830.5370295798330.0600974516056-0.02962852833230.60998552962-0.008611419405040.546242318077-57.632039338310.2210943003-5.50538040477
56.00596110606-0.729637113736-2.052282679623.06482809014-1.084555434924.73625874803-0.5753956779520.06075109769090.368887078556-0.01795502033490.183212349897-0.1660474088740.0142499965431-0.01050214029650.2625084091970.5367336157690.0352126103933-0.03823295701850.5390553672660.04726856588340.495641970585-58.77689876423.68902631934-23.1534488437
61.358514583810.07964553605040.5649107140451.67777476142-0.03942674037441.17565618871-0.08794420874480.297679790132-0.139746520504-0.4061614855040.2487932228730.08650543854530.27591671781-0.203760824506-0.1219640949020.560527447209-0.0615052627213-0.03859944690310.536170553407-0.03080350733230.428517830141-58.8757677397-2.59564888451-22.3791033776
71.338901250260.7867128451861.716544603881.896678514730.01108295483112.83419639530.172998910865-0.375214707957-0.596444601486-0.5927463907080.2472594084770.3952866457170.872036902946-0.612041344775-0.2453278923720.705661061731-0.176589698058-0.1089289883450.7078471326030.1252360789320.595223024887-64.2173627694-10.5398844901-19.8227634452
83.17531177811-0.01525748449450.290322986124.064716017340.4892183222173.61063492372-0.1192614627460.3415122466440.617484345518-0.9139594421690.218799561144-0.187441685250.01401802511790.387515863319-0.007117450076070.4564793850.0162557645338-0.03284875723610.3833357013880.01992511096190.487182854101-47.67163336264.49839739663-10.6146067929
92.866458779731.021616032412.210154286331.854550998341.35155018134.527995791380.04912978708950.129711438656-0.340968602351-0.6010560614640.086638560872-0.08514652534110.154902808093-0.693565085403-0.04572369816610.687456263107-0.0685855851939-0.05778701212830.5809888263630.01566721794050.485338316041-60.9414027694-4.99220194946-25.2837298691
100.5102222655970.1114428163610.02370290888660.9749743023950.7714554438422.61495552162-0.1140416104760.3629545915020.129031696473-0.260290707217-0.0210283644960.4126584986580.261217016276-0.632318460612-0.02823473227660.542798342228-0.0127503656628-0.1349268587980.7016813074020.1150362950410.548598341849-66.18458462482.30284868886-19.3950999852
110.6905852807060.1755298279330.5829729164880.481722720804-0.05867562495090.6321693357590.1459048643620.02881670682580.612534822717-0.1435663545130.0172947822864-0.3876900110660.0480264538598-0.05257839883550.004412531830060.4555264049470.009704645986840.01242378810120.428808904207-0.05777618395560.569273851496-33.9124690907-1.043064797110.579802646307
123.58519365880.1276811131791.915821162340.1506666054060.1922450828982.347655051930.334007182956-0.0171738532213-0.4894075795490.058672898649-0.0454195111977-0.2745145565770.4676460330550.0759686980694-0.2928491720460.4906078039020.02061641801470.006858658270390.432041549709-0.04792789486250.577413797163-5.82291029156-11.38297479533.32726129273
133.26058472738-0.668581094653-0.2591870022321.92643186481-0.3525212419661.12885273707-0.0285384186392-0.0001810066286280.04272961248820.02231964164740.0409052643055-0.03019991227360.0765960501318-0.141436599915-0.01226283086010.390055272097-0.0311314412160.04331534238240.398708457174-0.01170323560260.441327978963-16.8731595119-5.846716408675.62210963375
142.740463565260.7055518853591.77601297991.719703242850.7921311276372.538216540340.003402599105850.06734241378040.05183513386780.04902165927830.31682965864-0.510584043571-0.5742781788910.343505488455-0.409155414940.480399352894-0.01253511658340.0532271781570.460741291417-0.02616733804870.577992284459-9.08287295281.861905704821.51991912887
151.89163922002-0.705345071004-0.06703159084591.01823457041-0.957335558981.384575350960.08212652434060.008156657360980.06176934923730.000170234505255-0.113046530577-0.03244412518170.04649058854410.0128230898572-0.01842766495530.4427557358420.003935889724160.04734905148910.442162158348-0.0003354150371140.431494396468-11.3815763238-6.645314936994.45371615389
162.79299900197-0.9177599232831.511563226620.677499658579-0.2640876919362.179725970890.113222588048-0.856274464334-0.6223362610880.0279418526417-0.473375436713-0.550239588717-0.08858872372770.375049459910.2233766916270.548346742127-0.163512818144-0.0319391903150.8428008001860.2411724542410.6928532780055.6843517646-10.336899213715.1805482566
172.89319673008-0.564166580609-0.2570047256731.779965315391.434882578291.21304593755-0.624558960661-0.09502234200350.03780689601550.177879631377-0.154497136824-0.8714666993680.489360928808-0.1204185496030.4738647156660.9216713557560.168834033821-0.1926009969041.166445626080.2064820774590.90802150828210.8321652914-23.480292081438.7585987007
180.8468774203250.1651781721410.2713379416120.855625135490.111673383711.65158704888-0.3150650136820.301719688957-0.21796638365-0.40381312509-0.104950086959-0.5110388149850.09933233310670.2206851529470.2564403350760.886941190005-0.115406036190.095934040721.005779325330.2265100244340.8002142530410.5393418511-22.619565687422.4620308112
193.042790595470.893275599894-0.3729450248771.51279986188-0.01652788761422.68149569046-0.49242074677-0.418943747918-0.5272532475230.3911205210760.0195732668126-1.04040410009-0.01804796223960.8129466059770.4579121703350.7516042380070.0138938340058-0.04708966838640.8161938744640.2873718506950.7835396434898.67920571987-18.980335856727.3297471334
201.68528152778-0.585005752723-0.04298756782081.16869872011-0.946611049452.98510229195-0.1689606628430.700993890284-0.249061157587-0.4938978230960.680254002157-0.6509845810360.6889283313540.421617769974-0.1639171303320.964388209686-0.07610304197120.2145948355561.343307406020.3039481302871.2270346516719.3631837241-22.412569534322.9665559534
211.961453903030.009767491426180.5249204162412.43419005996-1.198562882642.354724289530.0830353369444-0.31230444916-0.1819051927490.0778419929988-0.02147708549490.01173086998120.2947890947980.00409977434911-0.04000575315410.497583307223-0.01760611504630.01371760300980.466905188768-0.03511075283110.433079375482-27.7800363567-17.178976637315.9838227842
222.29716881176-0.4316702311490.351676827251.24808446226-0.2774958474581.684710116970.0873887531254-0.340614514164-0.01363796010210.06915773605250.01799675771320.08038331679340.106803588016-0.0181554340468-0.1043514421750.498248377943-0.03969574078950.02603590378460.433177611922-0.01492265153530.456309621772-28.6230764453-15.877507219616.8682814656
231.68453483171-0.3391522797451.250720785710.147216216076-0.08691282152461.269012273660.528621029151-0.10572121094-0.364028036062-0.214616555604-0.4187502815260.1020380117320.6223968463720.347032249447-0.08977255250490.826594001624-0.0113821268424-0.06192595764640.5751275173850.1804220798390.606990427661-16.9022731709-30.112244777928.8080757239
242.656405616180.0462974394747-0.6347599356331.92328655013-0.8367719517242.58255219211-0.291284081697-0.4006232422520.02417943270430.021281248437-0.140076937988-0.383388044539-0.5081552860550.5064398259460.3983896276750.760128064138-0.0158655981735-0.1783209420360.7785610806030.1665216865180.5609603526541.09338061438-16.808993355234.236772658
252.53309621198-0.5245639375361.053377428831.580131214630.5499641526991.59490050536-0.204856269635-0.904348856034-0.7069608590480.5921494152930.0003826561542280.316378242604-0.0438644644963-0.07138081749010.212870270630.841889505879-0.0310427956036-0.06981756861631.069624382370.217794931080.489577667761-11.9915087928-24.445452701840.5640163194
Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

IDRefine TLS-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
11chain 'A' and (resid 1 through 84 )AA1 - 841 - 84
22chain 'A' and (resid 85 through 198 )AA85 - 19885 - 198
33chain 'A' and (resid 199 through 276 )AA199 - 276199 - 276
44chain 'B' and (resid 0 through 5 )BH0 - 51 - 6
55chain 'B' and (resid 6 through 11 )BH6 - 117 - 12
66chain 'B' and (resid 12 through 41 )BH12 - 4113 - 42
77chain 'B' and (resid 42 through 51 )BH42 - 5143 - 52
88chain 'B' and (resid 52 through 61 )BH52 - 6153 - 62
99chain 'B' and (resid 62 through 77 )BH62 - 7763 - 78
1010chain 'B' and (resid 78 through 99 )BH78 - 9979 - 100
1111chain 'C' and (resid 1 through 9 )CL1 - 91 - 9
1212chain 'D' and (resid 2 through 25 )DM2 - 251 - 24
1313chain 'D' and (resid 26 through 53 )DM26 - 5325 - 52
1414chain 'D' and (resid 54 through 66 )DM54 - 6653 - 65
1515chain 'D' and (resid 67 through 98 )DM67 - 9866 - 97
1616chain 'D' and (resid 99 through 115 )DM99 - 11598 - 114
1717chain 'D' and (resid 116 through 128 )DM116 - 128115 - 127
1818chain 'D' and (resid 129 through 149 )DM129 - 149128 - 148
1919chain 'D' and (resid 150 through 184 )DM150 - 184149 - 183
2020chain 'D' and (resid 185 through 198 )DM185 - 198184 - 197
2121chain 'E' and (resid 3 through 63 )ER3 - 631 - 61
2222chain 'E' and (resid 64 through 106 )ER64 - 10662 - 104
2323chain 'E' and (resid 107 through 121 )ER107 - 121105 - 119
2424chain 'E' and (resid 122 through 212 )ER122 - 212120 - 210
2525chain 'E' and (resid 213 through 242 )ER213 - 242211 - 240

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