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- PDB-9nds: Miniaturized HLA A*02-TAX bound to A6c134 TCR -

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Basic information

Entry
Database: PDB / ID: 9nds
TitleMiniaturized HLA A*02-TAX bound to A6c134 TCR
Components
  • A6c134 TCR alpha chain
  • A6c134 TCR beta chain
  • CSM8 A*02:01/MHC class I antigen chimera
  • X protein
KeywordsIMMUNE SYSTEM / synthetic protein / protein design / complex
Function / homology
Function and homology information


symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint / symbiont-mediated perturbation of host cell cycle progression / SH3 domain binding / host cell cytoplasm / positive regulation of DNA-templated transcription / host cell nucleus / zinc ion binding / membrane
Similarity search - Function
HTLV Tax / HTLV Tax / MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / : / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein
Similarity search - Domain/homology
X protein / MHC class I antigen
Similarity search - Component
Biological speciessynthetic construct (others)
Homo sapiens (human)
Human T-cell leukemia virus type I
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.4 Å
AuthorsJude, K.M. / Chen, X. / Chaudhuri, A. / White, W.L. / Sgourakis, N.G. / Baker, D.A. / Garcia, K.C.
Funding support United States, 1items
OrganizationGrant numberCountry
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)5R01AI103867-08 United States
CitationJournal: Proc.Natl.Acad.Sci.USA / Year: 2026
Title: Design of solubly expressed miniaturized SMART MHCs.
Authors: White, W.L. / Bai, H. / Kim, C.J. / Jude, K.M. / Sun, R. / Guerrero, L. / Han, X. / Chen, X. / Chaudhuri, A. / Bonzanini, J.E. / Sun, Y. / Onwuka, A.E. / Wang, N. / Wang, C. / Nygren, P.A. / ...Authors: White, W.L. / Bai, H. / Kim, C.J. / Jude, K.M. / Sun, R. / Guerrero, L. / Han, X. / Chen, X. / Chaudhuri, A. / Bonzanini, J.E. / Sun, Y. / Onwuka, A.E. / Wang, N. / Wang, C. / Nygren, P.A. / Li, X. / Goreshnik, I. / Allen, A. / Levine, P.M. / Kueh, H.Y. / Jewett, M.C. / Sgourakis, N.G. / Achour, A. / Garcia, K.C. / Baker, D.
History
DepositionFeb 18, 2025Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jan 14, 2026Provider: repository / Type: Initial release

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: CSM8 A*02:01/MHC class I antigen chimera
C: X protein
D: A6c134 TCR alpha chain
E: A6c134 TCR beta chain
H: CSM8 A*02:01/MHC class I antigen chimera
P: X protein
J: A6c134 TCR alpha chain
K: A6c134 TCR beta chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)166,03316
Polymers164,5148
Non-polymers1,5198
Water00
1
A: CSM8 A*02:01/MHC class I antigen chimera
C: X protein
D: A6c134 TCR alpha chain
E: A6c134 TCR beta chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)83,0178
Polymers82,2574
Non-polymers7604
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
H: CSM8 A*02:01/MHC class I antigen chimera
P: X protein
J: A6c134 TCR alpha chain
K: A6c134 TCR beta chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)83,0178
Polymers82,2574
Non-polymers7604
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)106.906, 106.906, 190.592
Angle α, β, γ (deg.)90.000, 90.000, 120.000
Int Tables number144
Space group name H-MP31
Space group name HallP31
Symmetry operation#1: x,y,z
#2: -y,x-y,z+1/3
#3: -x+y,-x,z+2/3
Noncrystallographic symmetry (NCS)NCS domain:
IDEns-IDDetails
d_1ens_1(chain "A" and (resid 1 through 55 or resid 72 through 248))
d_2ens_1(chain "H" and (resid 1 through 48 or (resid 49...
d_1ens_2chain "C"
d_2ens_2chain "P"
d_1ens_3(chain "D" and (resid 2 through 69 or (resid 70...
d_2ens_3(chain "J" and (resid 2 through 185 or (resid 186...
d_1ens_4(chain "E" and (resid 2 through 246 or resid 301))
d_2ens_4(chain "K" and (resid 2 through 245 or (resid 246...

NCS domain segments:
Dom-IDComponent-IDEns-IDBeg auth comp-IDBeg label comp-IDEnd auth comp-IDEnd label comp-IDAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
d_11ens_1ASPASPGLUGLUAA1 - 551 - 55
d_12ens_1SERSERTHRTHRAA72 - 24872 - 248
d_21ens_1ASPASPTHRTHRHE1 - 2481 - 248
d_11ens_2LEULEUVALVALCB1 - 91 - 9
d_21ens_2LEULEUVALVALPF1 - 91 - 9
d_11ens_3GLUGLUSERSERDC2 - 2062 - 200
d_12ens_3NAGNAGNAGNAGDI301
d_13ens_3NAGNAGNAGNAGDJ302
d_21ens_3GLUGLUSERSERJG2 - 2062 - 200
d_22ens_3NAGNAGNAGNAGJM301
d_23ens_3NAGNAGNAGNAGJN302
d_11ens_4ALAALAASPASPED2 - 2462 - 245
d_12ens_4NAGNAGNAGNAGEL301
d_21ens_4ALAALAASPASPKH2 - 2462 - 245
d_22ens_4NAGNAGNAGNAGKO301

NCS ensembles :
ID
ens_1
ens_2
ens_3
ens_4

NCS oper:
IDCodeMatrixVector
1given(0.737023096356, 0.675864184313, 0.00213536900303), (0.67397751395, -0.73472224759, -0.0770553670099), (-0.0505100596577, 0.0582307758765, -0.997024528592)-52.5757654544, -32.2065116363, -64.8918408688
2given(0.74333489236, 0.668831433344, 0.0108513396495), (0.668569356862, -0.742323304908, -0.0443973654098), (-0.0216391512324, 0.0402569840085, -0.99895501519)-52.242415662, -31.3179873304, -65.3440818316
3given(0.705491189259, 0.708282289296, -0.024867258565), (0.706353796695, -0.705568116384, -0.0569029615797), (-0.0578489046807, 0.0225794555364, -0.998069973707)-52.1565138652, -31.6151701012, -65.4216042116
4given(0.691186610178, 0.721927606665, -0.0328876974871), (0.720350931829, -0.691896556241, -0.0487205344341), (-0.0579275834535, 0.00998429751103, -0.998270859476)-52.189107081, -31.4896742631, -65.656909355

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Components

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Protein , 3 types, 6 molecules AHDJEK

#1: Protein CSM8 A*02:01/MHC class I antigen chimera


Mass: 29192.430 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Details: residues 1-56 are computationally designed. Residues 57-248 correspond to the A1 and A2 domains of human HLA A*02:01,residues 1-56 are computationally designed. Residues 57-248 correspond to ...Details: residues 1-56 are computationally designed. Residues 57-248 correspond to the A1 and A2 domains of human HLA A*02:01,residues 1-56 are computationally designed. Residues 57-248 correspond to the A1 and A2 domains of human HLA A*02:01
Source: (gene. exp.) synthetic construct (others), (gene. exp.) Homo sapiens (human)
Gene: HLA-A / Production host: Escherichia coli (E. coli) / References: UniProt: Q9TPS0
#3: Protein A6c134 TCR alpha chain


Mass: 23543.697 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)
#4: Protein A6c134 TCR beta chain


Mass: 28450.646 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)

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Protein/peptide / Sugars / Non-polymers , 3 types, 10 molecules CP

#2: Protein/peptide X protein


Mass: 1070.280 Da / Num. of mol.: 2 / Source method: obtained synthetically
Details: Tax residues 11-19 from Human T-cell lymphotropic virus type 1
Source: (synth.) Human T-cell leukemia virus type I / References: UniProt: Q80817
#5: Sugar
ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 6 / Source method: obtained synthetically / Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0
#6: Chemical ChemComp-SO4 / SULFATE ION


Mass: 96.063 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: SO4

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Details

Has ligand of interestN
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 3.82 Å3/Da / Density % sol: 67.82 % / Description: rods
Crystal growTemperature: 293 K / Method: vapor diffusion, sitting drop / Details: 50 mM magnesium formate, 17% PEG 3350 microseeded

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: NSLS-II / Beamline: 17-ID-1 / Wavelength: 0.9202 Å
DetectorType: DECTRIS EIGER X 9M / Detector: PIXEL / Date: Oct 17, 2024
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9202 Å / Relative weight: 1
ReflectionResolution: 3.4→46.62 Å / Num. obs: 33320 / % possible obs: 99.25 % / Redundancy: 3.5 % / Biso Wilson estimate: 107.63 Å2 / CC1/2: 0.976 / Rpim(I) all: 0.1707 / Rrim(I) all: 0.3274 / Rsym value: 0.2782 / Net I/σ(I): 4.33
Reflection shellResolution: 3.4→3.52 Å / Redundancy: 3.6 % / Mean I/σ(I) obs: 0.64 / Num. unique obs: 3374 / CC1/2: 0.149 / Rpim(I) all: 1.576 / Rrim(I) all: 3.046 / Rsym value: 2.599 / % possible all: 99.29

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Processing

Software
NameVersionClassification
PHENIX1.21.2_5419refinement
XDSdata reduction
PHASERphasing
XDSdata scaling
Aimlessdata reduction
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 3.4→46.62 Å / SU ML: 0.6698 / Cross valid method: FREE R-VALUE / σ(F): 1.96 / Phase error: 32.6818
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.269 1377 4.14 %
Rwork0.2182 31903 -
obs0.2204 33280 99.26 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 125.44 Å2
Refinement stepCycle: LAST / Resolution: 3.4→46.62 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms10866 0 94 0 10960
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.001911224
X-RAY DIFFRACTIONf_angle_d0.462415245
X-RAY DIFFRACTIONf_chiral_restr0.03931624
X-RAY DIFFRACTIONf_plane_restr0.00382005
X-RAY DIFFRACTIONf_dihedral_angle_d13.75254169
Refine LS restraints NCS
Ens-IDDom-IDAsym-IDAuth asym-IDRefine-IDTypeRms dev position (Å)
ens_1d_2AAX-RAY DIFFRACTIONTorsion NCS0.914810599341
ens_2d_2BCX-RAY DIFFRACTIONTorsion NCS0.837220313101
ens_3d_2CDX-RAY DIFFRACTIONTorsion NCS0.295885057848
ens_4d_2DEX-RAY DIFFRACTIONTorsion NCS0.326139766028
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
3.4-3.520.39571420.34843214X-RAY DIFFRACTION99.38
3.52-3.660.36811340.343207X-RAY DIFFRACTION99.52
3.66-3.830.38311370.30363219X-RAY DIFFRACTION99.73
3.83-4.030.3211360.283187X-RAY DIFFRACTION99.64
4.03-4.280.31541390.24693223X-RAY DIFFRACTION99.44
4.28-4.610.23311330.21443182X-RAY DIFFRACTION99.76
4.61-5.080.25431420.19323169X-RAY DIFFRACTION99.13
5.08-5.810.26211340.20943165X-RAY DIFFRACTION99.13
5.81-7.320.25661440.20023194X-RAY DIFFRACTION99.14
7.32-46.620.19211360.14393143X-RAY DIFFRACTION97.94
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
18.47980720368-0.124450671835-1.294592794842.77259926244-1.569253059413.74697658354-0.9130923427841.3474506279-1.49225315407-0.02667375103880.0444966352906-0.08012291815590.175080876736-0.3391447872430.6776724802921.551666127530.2037620336410.3315628787041.31826897885-0.3008673613441.4840502490212.817-21.973-52.195
25.47341787329-2.600052514511.103812603154.58273407690.9116397075670.886752333313-0.2955714634390.840633320819-1.78991476895-0.0847908726160.4546096830640.5500962743321.101726641430.849190735751-0.3820634701891.321962070320.2466353029450.0690655522041.29909214608-0.1793184746691.3727112825116.271-27.664-49.63
37.559590116231.24637046275-2.455355095067.88764480336-3.671807940498.3084814405-1.818418968080.497403436206-0.5587314009160.1682868070951.57752941938-0.5217622019182.76225031291-1.469603955840.01436442869491.650548828780.08092934213110.4410625895120.945264214042-0.3553291071181.429911382725.611-27.179-40.976
44.694399466032.27330954049-2.01337459623.9716976096-0.7457315152816.25231037558-0.3473179509840.126957396807-0.747234217669-0.547442810542-0.2077354091440.6360503089241.960468659290.3208904838220.4854772457521.186369367510.09752550077980.2190044048090.858146956406-0.09867610556871.123183187234.586-23.31-35.784
52.74334526515-0.3659518488030.4726624041317.26580217506-1.675591018266.33336267384-0.612886539235-0.943927219714-0.852579729959-0.068284744306-0.286361783591-1.813671535370.5661419255841.232311229150.7389020382540.7720559053530.1668139598990.0688605897021.347000455040.3503079598491.2732256691617.927-16.393-27.867
66.026793707350.767477261902-0.4489207497994.86136075243.504860381569.777652749150.07217203022570.590003453931-1.193988811730.63529841282-0.75265127661-1.301424684654.13705415425-0.493503532960.7290271298772.073596899710.2793803492830.3097629757031.440182082020.4218535501042.0253329908112.12-38.37-22.856
72.648065391630.951451533131-2.409751149174.23378976627-1.596597202652.9710935226-0.04044816507550.365708417163-2.23644714117-0.791924033882-1.736380024160.9399673778112.395902985310.6549849720711.549723813320.7638747617560.05202343351310.2090258154331.109632137560.3374091229391.252843872076.279-18.168-27.552
87.44067600529-4.69447048408-1.984197690873.409186796721.38434428431.32604237842-0.349417681751-1.26986602354-1.567367970550.433964537155-0.478606774815-0.2029548403171.00404117727-0.6230391448131.094250893931.34141931030.06631428944860.1238272618231.048957639510.3005040432111.26410217924-0.316-25.242.432
94.89552770435-4.70279489352-6.344496131465.0330252726.739086942538.84217623447-0.5706031676260.645913659595-1.02631149611-0.577767028357-0.1847244775632.262287469380.775125995038-0.8266510680220.1635330548381.172767968970.04892658310970.1078361841480.8681616194250.08645300854230.7911961368730.85-21.719-10.517
109.440877357532.22786552432-4.893665660694.926630332773.304696286687.36778442647-1.05543979641-0.9568594312460.01909205778050.7905765417490.541315516201-0.9497053357240.228507717271.42476606380.2786846851320.8794966135890.13788159557-0.1126638784781.167355816040.3474950337860.7715067702195.065-15.572-4.116
118.932673868572.97253726296-2.247898377965.49016176139-3.474250708322.22909386722-0.9324778548981.07868886285-0.872962948373-1.04666306273-0.45071422823-1.822569135171.140301083471.00251809040.3980123208971.366579964460.299659869001-0.06158816204431.148834717560.4721121689381.510259353916.973-28.926-7.059
124.396131530760.64248074108-1.842817264956.36824979933-0.623556075476.76823617406-0.130254067726-0.1883289560060.01144373810760.5153685906190.560559553473-0.440410078769-0.1299885391880.172418071558-0.442045125750.8066658475240.00636337734701-0.09664505134910.8317005122260.2046705456590.84649654061-0.957-18.459-5.522
135.29372259248-6.70574864942-5.166061886978.541540822337.45248459857.65115257966-0.4335279484150.1948515446781.965262418161.668905910750.695841086886-0.918944113860.8038402047591.013601625520.1360065969251.53639903541-0.267662511814-0.427111179711.221855224040.4061797782681.20007703738-2.918-13.74118.489
148.13622417443-1.855007734543.05435018484.9400698553-0.4046278750577.79607430973-0.0319181516644-0.710919944856-0.5319563073151.385133273450.1606337449050.5486772699280.458614060568-0.50036998356-0.1727304048921.53651999841-0.07309662907460.1256788621.070981602490.02671837490820.925539133808-19.776-8.71323.047
155.182876988835.56419957943-1.016307668355.53015102626-1.70694048965.73024394508-0.1794572020732.104801479810.764381614547-0.9687674141890.4704111804210.4660855889470.402971667274-0.243849177426-0.007498388919511.055811624250.233055777641-0.129828525181.143981424740.1647878468961.05201934641-10.329-6.34516.782
164.250782654521.424470808-6.311077577480.805964261835-2.197644371329.36388109873-1.57516468215-1.67148291175-1.95123555559-0.221967380660.393791428911-0.1487042398390.492891592137-1.090030845411.197777505611.302026036110.003837915335040.1407905350711.37039914599-0.0203014510550.796030492819-20.669-8.79222.692
176.464882660483.916726843752.926207167642.408927755111.861225648491.336594929890.831991547843-1.87688094912-2.077119216341.97719165395-1.017237899460.6127932491791.22472836730.426400026204-0.6284650413271.84795685346-0.07385166912860.1360857608291.062117666350.2773902718971.4601265232-17.317-15.05430.166
187.77593718091.57213589057-3.876403616912.02244003622-0.1892659300593.959028670290.6240748406950.3862399319840.259946414369-0.085790655467-0.1580629552950.357414176967-0.641748470878-0.969820020657-0.2326140116430.621522986566-0.0199683310907-0.1608115940580.933067715398-0.1320042978930.918661986679-19.634-4.985-13.743
196.3452744539-1.352699455521.656611326522.072544338750.9940135643544.84740435238-0.3136676088530.0787464237383-0.293240957953-0.532056462841-0.323356925713-0.01222296135360.417154669095-0.7006001844380.4836477457180.815635756567-0.0816522659434-0.03524248494390.737250625013-0.02427849335310.852939885814-14.901-13.783-20.262
203.71750441926-1.93998550727-4.534133222424.617026897831.323825786526.94115810667-0.403050770395-0.1308450184941.66757222959-0.1104512198410.546796658584-0.1285813885060.2109411013250.280143472638-0.06066138045110.639275146723-0.160090827098-0.1585466003950.8406506466410.1330761521950.966790665047-11.368-11.708-13.574
218.04054860911.024868739530.6026932740163.850340354782.471620576033.806565606780.511979248519-0.193633961073-0.02810263544420.952593424104-0.6234225472650.3406544186031.01052680943-1.028921144020.02835997047480.969010012621-0.08496279142210.1994666071730.672335862158-0.003236605795450.839966912162-23.422-0.92715.593
226.070940007013.4502026972.339764784474.096334411372.433473467469.99847511833-0.1579027003490.579885712102-0.4625449965270.2477694091920.1130307627410.2630227766980.02370628014830.004079574487720.0574774378960.7136017258790.0825186010198-0.07443211829650.775840043109-0.1018688249140.884964401181-20.335-3.518.732
239.119577707260.9821216382386.544965269614.378213198492.169633012315.00789443999-0.318089030105-0.7357062504360.2208422275811.09009758303-0.458321654140.862710820660.0891101551355-1.648155609470.7667759246450.967407043365-0.06138069161640.02003293213840.9179954385770.08409328106670.807864301759-15.85.54315.418
245.37010379622-1.377722521776.285141162498.9524835891-1.972641945437.3757891039-0.7928094066872.100423810662.68442586415-0.998169640619-0.170891707571.49072426493-0.572940704968-0.8295797842960.6098636295780.9861152970590.224884212564-0.4823125649961.99280380498-0.1389891402611.31840470321-35.7521.48-4.706
258.715635469443.196737866412.729124621271.599114466251.816845515432.09529688561-0.968360677972-0.1270301387571.72980974119-0.35342189-1.20081136281.19429388465-0.462163400163-0.165860997322.661496427121.190615365250.209506692066-0.02667348025120.864706537855-0.06011665372521.31987736129-21.50610.05515.44
261.34595472652-2.68901233496-1.445568609269.154109540322.049935738781.8411745765-0.2190058721670.266680986351-0.873023592767-0.3600239556520.05756009070112.508494280740.135084481131-0.738370510295-0.4011063385720.570161396004-0.00447648326277-0.00698895313791.43134525783-0.1884219124591.14735311443-60.03-12.418-38.691
273.944825896941.762138189890.6808748219525.322015481273.086051753352.949560185140.0616003939858-0.284053589701-0.1722593028540.191896070526-0.2143698766080.9509989810360.559338941075-0.2043050923280.1914289961970.827706185807-0.0860834683824-0.02648598994660.944291203863-0.0001761069760460.954370753679-70.419-33.532-47.789
287.003380101631.04110170648-6.114761335382.78301319267-1.077606256339.7326836046-0.3517937405061.41590132821-0.327376856332-1.099157414310.09415851854810.5622270786930.470749829346-1.430655857370.4577614171411.273322344-0.125251808518-0.2514087751041.03453205813-0.103493424820.842273001524-69.539-48.487-79.925
297.240422778631.6418657205-2.719445794691.24056199691.749362642595.80938218565-0.3447292618-0.7096580758320.8365673480710.1861484351690.3128681294690.209017621571-0.335794576055-0.3945888239910.0508921635741.1548755282-0.0630880716174-0.1430815363250.720670297144-0.01375547772650.851988561149-69.019-44.123-73.228
309.24641548344-0.176576181165-8.009228022370.570235135947-0.01184396912716.52147801951-0.868797800009-1.02518342814-0.253182146615-0.1299199976840.1625292135730.5212086888330.4480000702410.5127934264140.5280915093011.20692530552-0.26630940629-0.3037155291480.9053656504660.04649246087430.841698059856-61.889-43.648-82.218
316.850651377241.48920965471-2.109828412374.76214626591-2.666912711572.87333007916-0.170138358087-0.310578291611-0.2434743760330.3508997674110.325402382478-0.0420476395641.30360662330.01344022839070.02143830397511.02167121802-0.01770639419070.03010222356480.4560837281480.1498801651161.03772685466-57.443-51.395-78.071
326.891695274253.05296798187-1.66793370851.9100776866-1.204226535478.735249714830.638517477324-1.23770993318-0.8780396107170.571961344429-0.895413024334-0.185911783977-0.763491430066-0.848064268770.4179967533991.29673459758-0.06653032379280.03621776518340.7675872034670.1960077938820.977508224033-69.667-56.711-67.238
333.46702700020.7223505687221.072282970062.12264973032-0.1378788866850.2958830786940.0846268489689-0.09737914830780.360445317283-0.9347541366920.101161291370.349698497544-0.0312636177429-0.577148211466-0.2110401320081.310418888370.104458281432-0.2355638992750.842392591679-0.09618102793130.866271098884-68.933-14.491-63.494
344.335594192915.771183638172.595242899238.758906607964.515857037762.788323927720.0904808262765-1.0121693390.700733939169-0.872061191203-0.8186572336420.306248876026-0.3331958550860.5827975175210.4306983539681.07464065591-0.0115268934492-0.2331284382040.919367746248-0.01958060815161.15867991837-61.543-20.574-59.749
354.84722367192-0.8840635458760.1804968083054.274543582375.029233044079.15402824391-0.2390989717610.08705395434540.849451188927-1.107684420270.9723688644130.0629634089982-0.486528208183-0.209764968961-0.5829499824291.200903923810.0312618313285-0.01349665659780.8737858897680.1223073628721.03726009476-62.364-13.796-64.902
365.14104049112-0.1438258568753.884655445857.174562211420.123991554582.990477616320.09243637894730.197826727944-0.203379573091-0.4627107976711.504241316811.35247271327-1.10370014374-2.02044896821-2.28560344410.760344220121-0.0889131275968-0.1190981782031.399790349910.01762135651431.1748808579-70.028-18.228-48.511
379.93350945362-7.02292742651-5.005620853079.371622844043.73347569472.440621296820.2371055286810.1964923620221.890179338650.3514727112361.09285870695-1.232842692672.99969663115-0.480338985409-0.5206871673061.39898824705-0.0532501702348-0.1557837637750.995752739048-0.01954355013280.90182724412-64.427-24.986-84.007
383.37094762159-1.496360758110.8578048131842.80913261069-2.612301917885.119266001580.4002432048340.688731638747-0.620408125438-0.557940761285-0.5121086663120.7788221708820.0706036934381-0.215801041383-0.1443326154441.335640939070.0455196047228-0.3713308721381.19564851702-0.1627636500491.04658754199-72.813-40.749-87.472
398.58575141722.47485714434-1.00745631422.56568100043-2.179043911096.69472967888-1.78892250272-1.35645561721-0.436647960978-0.6181251344731.25800136938-0.0720769277175-0.14074162774-0.3038731532330.2424735035251.38469924221-0.0810911317322-0.1143477502840.6905829199330.1379620639990.834879803449-64.325-35.387-81.757
405.103062237042.714247194746.751691431823.598011428834.257007000858.83280402749-0.784715246315-1.30762436831.895544642920.186854080626-0.3038330207351.462169255770.135393977627-1.234740000091.392814188151.853789708140.036621241458-0.1136651978361.06439688314-0.1387896819361.04497132938-73.845-41.525-87.135
416.015845129646.15322265934-3.784983917477.04275958825-2.304582585914.6769413374-0.2669076407912.505114999821.74660003197-0.04866839048650.300772852661.37440547036-3.2671742-0.956898849177-0.07660625216221.92363790510.199685583026-0.4199372629681.602001303370.06003683074721.3245595722-75.825-34.858-94.87
429.86939355709-0.4615654587410.9271442166475.60167910813-5.6001191915.648128874370.2905917328460.03505900879430.2419177791460.975248126806-2.073897834360.412152696622-0.1462267103310.4338006695031.950784558750.987392022575-0.0133057856492-0.09021978828421.38728695834-0.6143363796731.35701045314-54.357-3.545-16.946
431.99353682913-0.1116590385584.659379738265.11211937234-3.127680841463.89837997458-0.514949389209-3.64296181489-0.2806359179711.820371838910.4483613753670.917275272417-1.65047948749-1.088174949630.2848722244161.28447400290.3547367563870.04507575927451.66977510749-0.5759404951871.64285091075-62.988-3.494-12.077
442.289292069741.24991247065-2.912613966143.84989438331-4.98811502328.925903665630.0625122825673-0.9367289169690.3749695773861.320044411740.43794804790.0344771301208-2.170120252240.889607504133-0.51763836291.07054379274-0.0015744536806-0.009425312392831.59959633725-0.4247146333661.44135696708-58.482.83-18.067
459.2097566724-0.7129731170413.184919855655.38670000717-5.722501866438.88153478518-0.120093342762-0.7525491782110.1615848355290.4994908092620.0747011084713-0.236825409692-1.00011581311-1.14212646133-0.003143683668390.8569081886320.1534157552860.01592842238491.38861036327-0.5457523453971.08313434597-70.905-4.272-28.821
462.60718843492-3.402646699192.276622859086.46210096073-1.199649812732.726222549280.00219267114045-0.663949532581-0.586465163594-0.4204547977160.4022375503380.624309114438-0.0202547772496-0.45240553299-0.5356627208570.680649786242-0.1081174512890.09540078256481.37182220793-0.1307716883891.02929287213-63.795-13.69-32.272
477.77532497550.01277953049443.223888588064.59019184878-2.539100082648.27577162495-0.917192810815-0.8097118016961.297168333220.6812468795280.247071436502-0.0462259524179-1.69021831741-1.019283685160.8592189771550.7321400944840.0706575008538-0.1770858105161.28885802142-0.411148772071.12081521683-55.228-3.117-32.989
483.48058482503-0.8980393169482.085924329756.19651496692-1.668116814736.871530116150.17483116041-0.1798880815850.836450621343-0.156066242467-0.323333933381-0.345772953984-0.3287420249151.008160866850.208917327220.819003255013-0.04789155748230.1161448575161.16557025767-0.2809440515291.0291237651-48.669-9.087-38.444
493.51880201488-0.1455709645612.626511680443.99330116964-3.395503059234.617206391980.183525364931-0.517597934381.3554517499-0.4020366839950.6255124117784.3195345378-2.50260265922-1.50997214313-1.06754193451.41998709190.03166607577010.2675383938081.55080586203-0.250293174682.10860244816-69.7255.848-44.984
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN A AND RESID 1:38 )A1 - 38
2X-RAY DIFFRACTION2( CHAIN A AND RESID 39:82 )A39 - 82
3X-RAY DIFFRACTION3( CHAIN A AND RESID 83:107 )A83 - 107
4X-RAY DIFFRACTION4( CHAIN A AND RESID 108:173 )A108 - 173
5X-RAY DIFFRACTION5( CHAIN A AND RESID 174:232 )A174 - 232
6X-RAY DIFFRACTION6( CHAIN A AND RESID 233:248 )A233 - 248
7X-RAY DIFFRACTION7( CHAIN C AND RESID 1:9 )C1 - 9
8X-RAY DIFFRACTION8( CHAIN D AND ( RESID 2:24 OR RESID 301:301 ) )D2 - 24
9X-RAY DIFFRACTION8( CHAIN D AND ( RESID 2:24 OR RESID 301:301 ) )D301
10X-RAY DIFFRACTION9( CHAIN D AND RESID 25:37 )D25 - 37
11X-RAY DIFFRACTION10( CHAIN D AND RESID 38:65 )D38 - 65
12X-RAY DIFFRACTION11( CHAIN D AND RESID 66:75 )D66 - 75
13X-RAY DIFFRACTION12( CHAIN D AND RESID 76:109 )D76 - 109
14X-RAY DIFFRACTION13( CHAIN D AND RESID 110:123 )D110 - 123
15X-RAY DIFFRACTION14( CHAIN D AND RESID 124:157 )D124 - 157
16X-RAY DIFFRACTION15( CHAIN D AND RESID 158:172 )D158 - 172
17X-RAY DIFFRACTION16( CHAIN D AND RESID 173:191 )D173 - 191
18X-RAY DIFFRACTION17( CHAIN D AND ( RESID 192:206 OR RESID 302:302 ) )D192 - 206
19X-RAY DIFFRACTION17( CHAIN D AND ( RESID 192:206 OR RESID 302:302 ) )D302
20X-RAY DIFFRACTION18( CHAIN E AND RESID 1:25 )E1 - 25
21X-RAY DIFFRACTION19( CHAIN E AND ( RESID 26:83 OR RESID 301:301 ) )E26 - 83
22X-RAY DIFFRACTION19( CHAIN E AND ( RESID 26:83 OR RESID 301:301 ) )E301
23X-RAY DIFFRACTION20( CHAIN E AND RESID 84:116 )E84 - 116
24X-RAY DIFFRACTION21( CHAIN E AND RESID 117:141 )E117 - 141
25X-RAY DIFFRACTION22( CHAIN E AND RESID 142:189 )E142 - 189
26X-RAY DIFFRACTION23( CHAIN E AND RESID 190:216 )E190 - 216
27X-RAY DIFFRACTION24( CHAIN E AND RESID 217:234 )E217 - 234
28X-RAY DIFFRACTION25( CHAIN E AND RESID 235:246 )E235 - 246
29X-RAY DIFFRACTION26( CHAIN P AND RESID 1:9 )P1 - 9
30X-RAY DIFFRACTION27( CHAIN K AND ( RESID 3:116 OR RESID 301:301 ) )K3 - 116
31X-RAY DIFFRACTION27( CHAIN K AND ( RESID 3:116 OR RESID 301:301 ) )K301
32X-RAY DIFFRACTION28( CHAIN K AND RESID 117:141 )K117 - 141
33X-RAY DIFFRACTION29( CHAIN K AND RESID 142:189 )K142 - 189
34X-RAY DIFFRACTION30( CHAIN K AND RESID 190:203 )K190 - 203
35X-RAY DIFFRACTION31( CHAIN K AND RESID 204:216 )K204 - 216
36X-RAY DIFFRACTION32( CHAIN K AND RESID 217:246 )K217 - 246
37X-RAY DIFFRACTION33( CHAIN J AND ( RESID 2:37 OR RESID 301:301 ) )J2 - 37
38X-RAY DIFFRACTION33( CHAIN J AND ( RESID 2:37 OR RESID 301:301 ) )J301
39X-RAY DIFFRACTION34( CHAIN J AND RESID 38:52 )J38 - 52
40X-RAY DIFFRACTION35( CHAIN J AND RESID 53:93 )J53 - 93
41X-RAY DIFFRACTION36( CHAIN J AND RESID 98:109 )J98 - 109
42X-RAY DIFFRACTION37( CHAIN J AND RESID 110:123 )J110 - 123
43X-RAY DIFFRACTION38( CHAIN J AND RESID 124:157 )J124 - 157
44X-RAY DIFFRACTION39( CHAIN J AND RESID 158:172 )J158 - 172
45X-RAY DIFFRACTION40( CHAIN J AND RESID 173:191 )J173 - 191
46X-RAY DIFFRACTION41( CHAIN J AND ( RESID 192:206 OR RESID 302:302 ) )J192 - 206
47X-RAY DIFFRACTION41( CHAIN J AND ( RESID 192:206 OR RESID 302:302 ) )J302
48X-RAY DIFFRACTION42( CHAIN H AND RESID 1:20 )H1 - 20
49X-RAY DIFFRACTION43( CHAIN H AND RESID 21:38 )H21 - 38
50X-RAY DIFFRACTION44( CHAIN H AND RESID 39:82 )H39 - 82
51X-RAY DIFFRACTION45( CHAIN H AND RESID 83:126 )H83 - 126
52X-RAY DIFFRACTION46( CHAIN H AND RESID 127:155 )H127 - 155
53X-RAY DIFFRACTION47( CHAIN H AND RESID 156:188 )H156 - 188
54X-RAY DIFFRACTION48( CHAIN H AND RESID 189:232 )H189 - 232
55X-RAY DIFFRACTION49( CHAIN H AND RESID 233:248 )H233 - 248

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