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Structure paper

TitleDesign of solubly expressed miniaturized SMART MHCs.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 123, Page e2505932123-e2505932123, Year 2026
Publish dateJan 9, 2025 (structure data deposition date)
AuthorsWhite, W.L. / Bai, H. / Kim, C.J. / Jude, K.M. / Sun, R. / Guerrero, L. / Han, X. / Chen, X. / Chaudhuri, A. / Bonzanini, J.E. ...White, W.L. / Bai, H. / Kim, C.J. / Jude, K.M. / Sun, R. / Guerrero, L. / Han, X. / Chen, X. / Chaudhuri, A. / Bonzanini, J.E. / Sun, Y. / Onwuka, A.E. / Wang, N. / Wang, C. / Nygren, P.A. / Li, X. / Goreshnik, I. / Allen, A. / Levine, P.M. / Kueh, H.Y. / Jewett, M.C. / Sgourakis, N.G. / Achour, A. / Garcia, K.C. / Baker, D.
External linksProc. Natl. Acad. Sci. USA / PubMed:41481462
MethodsX-ray diffraction
Resolution2 - 3.4 Å
Structure data

PDB-9hy4:
Solubly expressed miniaturized SMART H2-Db
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-9nds:
Miniaturized HLA A*02-TAX bound to A6c134 TCR
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

Source
  • mus musculus (house mouse)
  • mammarenavirus choriomeningitidis
  • synthetic construct (others)
  • homo sapiens (human)
  • human t-cell leukemia virus type i
KeywordsIMMUNE SYSTEM / MHC / soluble expression / synthetic protein / protein design / complex

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