登録情報 | データベース: PDB / ID: 9m3n |
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タイトル | Crystal structure of human TRIM21 PRYSPRY in complex with T-02 |
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要素 | E3 ubiquitin-protein ligase TRIM21 |
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キーワード | LIGASE / complex / E3 ligase |
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機能・相同性 | 機能・相同性情報
suppression of viral release by host / protein K27-linked ubiquitination / negative regulation of protein deubiquitination / regulation of type I interferon production / negative regulation of viral transcription / protein K6-linked ubiquitination / STING mediated induction of host immune responses / cellular response to chemical stress / stress granule disassembly / negative regulation of NF-kappaB transcription factor activity ...suppression of viral release by host / protein K27-linked ubiquitination / negative regulation of protein deubiquitination / regulation of type I interferon production / negative regulation of viral transcription / protein K6-linked ubiquitination / STING mediated induction of host immune responses / cellular response to chemical stress / stress granule disassembly / negative regulation of NF-kappaB transcription factor activity / pyroptotic inflammatory response / protein K63-linked ubiquitination / response to type II interferon / protein monoubiquitination / protein K48-linked ubiquitination / proteasomal protein catabolic process / protein autoubiquitination / positive regulation of cell cycle / positive regulation of autophagy / antiviral innate immune response / positive regulation of DNA-binding transcription factor activity / Regulation of innate immune responses to cytosolic DNA / autophagosome / negative regulation of innate immune response / P-body / protein destabilization / RING-type E3 ubiquitin transferase / positive regulation of protein binding / protein polyubiquitination / cytoplasmic stress granule / Interferon gamma signaling / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / KEAP1-NFE2L2 pathway / Antigen processing: Ubiquitination & Proteasome degradation / regulation of gene expression / cytoplasmic vesicle / transcription coactivator activity / positive regulation of viral entry into host cell / protein ubiquitination / ribonucleoprotein complex / innate immune response / DNA binding / RNA binding / zinc ion binding / nucleoplasm / identical protein binding / nucleus / cytosol / cytoplasm類似検索 - 分子機能 TRIM21, PRY/SPRY domain / Zinc finger, B-box, chordata / Modified RING finger domain / U-box domain / : / SPRY-associated domain / SPRY-associated / PRY / Butyrophylin-like, SPRY domain / B-box zinc finger ...TRIM21, PRY/SPRY domain / Zinc finger, B-box, chordata / Modified RING finger domain / U-box domain / : / SPRY-associated domain / SPRY-associated / PRY / Butyrophylin-like, SPRY domain / B-box zinc finger / B-Box-type zinc finger / B-box-type zinc finger / Zinc finger B-box type profile. / Zinc finger, C3HC4 RING-type / Zinc finger, C3HC4 type (RING finger) / SPRY domain / B30.2/SPRY domain / B30.2/SPRY domain profile. / B30.2/SPRY domain superfamily / Domain in SPla and the RYanodine Receptor. / SPRY domain / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Ring finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Concanavalin A-like lectin/glucanase domain superfamily / Zinc finger, RING/FYVE/PHD-type類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.08 Å |
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データ登録者 | Zhang, L.J. / Zhang, L.Y. |
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資金援助 | 1件 |
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引用 | ジャーナル: J.Chem.Inf.Model. / 年: 2025 タイトル: TRIM21-Driven Degradation of BRD4: Development of Heterobifunctional Degraders and Investigation of Recruitment and Selectivity Mechanisms. 著者: Zhang, L. / Wang, Q. / Li, X. / Cheng, X. / Cai, L. / Guo, A. / Zhang, L. / Hu, H. / Wu, M. / Li, X. / Li, H. / Meng, X. / Qiu, Y. / Tu, G. / Zhang, L. / Dong, X. / Liang, Y. / Wang, Y. / Li, ...著者: Zhang, L. / Wang, Q. / Li, X. / Cheng, X. / Cai, L. / Guo, A. / Zhang, L. / Hu, H. / Wu, M. / Li, X. / Li, H. / Meng, X. / Qiu, Y. / Tu, G. / Zhang, L. / Dong, X. / Liang, Y. / Wang, Y. / Li, J. / Dou, D. / Pu, X. |
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履歴 | 登録 | 2025年3月3日 | 登録サイト: PDBJ / 処理サイト: PDBC |
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改定 1.0 | 2025年7月16日 | Provider: repository / タイプ: Initial release |
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