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TitleTRIM21-Driven Degradation of BRD4: Development of Heterobifunctional Degraders and Investigation of Recruitment and Selectivity Mechanisms.
Journal, issue, pagesJ. Chem. Inf. Model., Vol. 65, Page 7584-7604, Year 2025
Publish dateMar 3, 2025 (structure data deposition date)
AuthorsZhang, L. / Wang, Q. / Li, X. / Cheng, X. / Cai, L. / Guo, A. / Hu, H. / Wu, M. / Li, H. / Meng, X. ...Zhang, L. / Wang, Q. / Li, X. / Cheng, X. / Cai, L. / Guo, A. / Hu, H. / Wu, M. / Li, H. / Meng, X. / Qiu, Y. / Tu, G. / Dong, X. / Liang, Y. / Wang, Y. / Li, J. / Dou, D. / Pu, X.
External linksJ. Chem. Inf. Model. / PubMed:40623734
MethodsX-ray diffraction
Resolution2.08 Å
Structure data

PDB-9m3n:
Crystal structure of human TRIM21 PRYSPRY in complex with T-02
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

Chemicals

PDB-1emt:
FAB ANTIBODY FRAGMENT OF AN C60 ANTIFULLERENE ANTIBODY

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / complex / E3 ligase

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