登録情報 | データベース: PDB / ID: 9gh7 |
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タイトル | Complex of human TfR1 with a potent bicyclic peptide |
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要素 | - Bicyclic peptide
- Transferrin receptor protein 1
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キーワード | TRANSPORT PROTEIN / Transferrin receptor protein 1 |
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機能・相同性 | 機能・相同性情報
transferrin receptor activity / postsynaptic recycling endosome membrane / negative regulation of mitochondrial fusion / positive regulation of isotype switching / Transferrin endocytosis and recycling / response to manganese ion / response to copper ion / Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin / response to iron ion / RND1 GTPase cycle ...transferrin receptor activity / postsynaptic recycling endosome membrane / negative regulation of mitochondrial fusion / positive regulation of isotype switching / Transferrin endocytosis and recycling / response to manganese ion / response to copper ion / Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin / response to iron ion / RND1 GTPase cycle / RND2 GTPase cycle / RHOB GTPase cycle / Golgi Associated Vesicle Biogenesis / RHOC GTPase cycle / RHOJ GTPase cycle / RHOQ GTPase cycle / CDC42 GTPase cycle / RHOH GTPase cycle / RHOG GTPase cycle / RHOA GTPase cycle / RAC2 GTPase cycle / RAC3 GTPase cycle / response to retinoic acid / regulation of postsynaptic membrane neurotransmitter receptor levels / transport across blood-brain barrier / clathrin-coated pit / positive regulation of B cell proliferation / positive regulation of T cell proliferation / RAC1 GTPase cycle / response to nutrient / Hsp70 protein binding / osteoclast differentiation / cellular response to leukemia inhibitory factor / transferrin transport / acute-phase response / positive regulation of protein-containing complex assembly / clathrin-coated endocytic vesicle membrane / iron ion transport / HFE-transferrin receptor complex / recycling endosome / receptor internalization / multicellular organismal-level iron ion homeostasis / positive regulation of protein localization to nucleus / recycling endosome membrane / Cargo recognition for clathrin-mediated endocytosis / cellular response to xenobiotic stimulus / Clathrin-mediated endocytosis / melanosome / extracellular vesicle / double-stranded RNA binding / virus receptor activity / cytoplasmic vesicle / blood microparticle / basolateral plasma membrane / intracellular iron ion homeostasis / response to hypoxia / early endosome / positive regulation of canonical NF-kappaB signal transduction / endosome membrane / endosome / intracellular signal transduction / external side of plasma membrane / intracellular membrane-bounded organelle / positive regulation of gene expression / negative regulation of apoptotic process / protein kinase binding / protein-containing complex binding / perinuclear region of cytoplasm / glutamatergic synapse / cell surface / protein homodimerization activity / extracellular space / RNA binding / extracellular exosome / extracellular region / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Transferrin receptor protein 1/2, PA domain / Transferrin receptor-like, dimerisation domain / Transferrin receptor-like, dimerisation domain superfamily / Glutamate carboxypeptidase 2-like / Transferrin receptor-like dimerisation domain / PA domain superfamily / PA domain / PA domain / Peptidase M28 / Peptidase family M28類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) synthetic construct (人工物) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.079 Å |
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データ登録者 | Pellegrino, S. / Pernigo, S. / Swan, M.K. / Bezerra, G.A. / Chen, L. |
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資金援助 | 英国, 1件 組織 | 認可番号 | 国 |
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Not funded | | 英国 |
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引用 | ジャーナル: Nucleic Acids Res. / 年: 2025 タイトル: Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles. 著者: Ostergaard, M.E. / Carrer, M. / Anderson, B.A. / Afetian, M. / Bakooshli, M.A. / Santos, J.A. / Klein, S.K. / Capitanio, J. / Freestone, G.C. / Tanowitz, M. / Galindo-Murillo, R. / Gaus, H.J. ...著者: Ostergaard, M.E. / Carrer, M. / Anderson, B.A. / Afetian, M. / Bakooshli, M.A. / Santos, J.A. / Klein, S.K. / Capitanio, J. / Freestone, G.C. / Tanowitz, M. / Galindo-Murillo, R. / Gaus, H.J. / Dwyer, C.A. / Jackson, M. / Jafar-Nejad, P. / Rigo, F. / Seth, P.P. / Gaynor, K.U. / Stanway, S.J. / Urbonas, L. / St Denis, M.A. / Pellegrino, S. / Bezerra, G.A. / Rigby, M. / Gowans, E. / Van Rietschoten, K. / Beswick, P. / Chen, L. / Skynner, M.J. / Swayze, E.E. |
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履歴 | 登録 | 2024年8月15日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2025年4月30日 | Provider: repository / タイプ: Initial release |
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