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Open data
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Basic information
Entry | Database: PDB / ID: 9f50 | ||||||
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Title | UP1 in complex with Z906021418 | ||||||
![]() | Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed | ||||||
![]() | RNA BINDING PROTEIN / fragment screening / hnRNP A1 / UP1 / RNA/DNA BINDING PROTEIN / UP1-fragment complex | ||||||
Function / homology | ![]() cellular response to sodium arsenite / SARS-CoV-1-host interactions / import into nucleus / telomeric repeat-containing RNA binding / G-rich strand telomeric DNA binding / pre-mRNA binding / nuclear export / RNA export from nucleus / miRNA binding / FGFR2 alternative splicing ...cellular response to sodium arsenite / SARS-CoV-1-host interactions / import into nucleus / telomeric repeat-containing RNA binding / G-rich strand telomeric DNA binding / pre-mRNA binding / nuclear export / RNA export from nucleus / miRNA binding / FGFR2 alternative splicing / regulation of alternative mRNA splicing, via spliceosome / SARS-CoV-1 modulates host translation machinery / regulation of RNA splicing / negative regulation of telomere maintenance via telomerase / Processing of Capped Intron-Containing Pre-mRNA / mRNA transport / cellular response to glucose starvation / positive regulation of telomere maintenance via telomerase / catalytic step 2 spliceosome / mRNA Splicing - Major Pathway / mRNA 3'-UTR binding / spliceosomal complex / mRNA splicing, via spliceosome / single-stranded DNA binding / single-stranded RNA binding / ribonucleoprotein complex / protein domain specific binding / DNA binding / RNA binding / extracellular exosome / nucleoplasm / identical protein binding / membrane / nucleus / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Dunnett, L. / Prischi, F. | ||||||
Funding support | 1items
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![]() | ![]() Title: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening Authors: Dunnett, L. / Prischi, F. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 58.3 KB | Display | ![]() |
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PDB format | ![]() | 36.3 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 9f4dC ![]() 9f4eC ![]() 9f4fC ![]() 9f4gC ![]() 9f4hC ![]() 9f4jC ![]() 9f4kC ![]() 9f4lC ![]() 9f4mC ![]() 9f4nC ![]() 9f4oC ![]() 9f4pC ![]() 9f4qC ![]() 9f4rC ![]() 9f4sC ![]() 9f4tC ![]() 9f4uC ![]() 9f4vC ![]() 9f4wC ![]() 9f4xC ![]() 9f4yC ![]() 9f4zC ![]() 9f51C ![]() 9f52C ![]() 9f53C ![]() 9f54C ![]() 9f55C ![]() 9f5cC ![]() 9f5dC ![]() 9f5eC ![]() 9f5fC ![]() 9f5gC ![]() 9f5kC ![]() 9f7fC ![]() 9f7hC C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 22357.109 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
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#2: Chemical | ChemComp-K2G / |
#3: Water | ChemComp-HOH / |
Has ligand of interest | Y |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.08 Å3/Da / Density % sol: 40.95 % |
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Crystal grow | Temperature: 289 K / Method: vapor diffusion, sitting drop / pH: 8.5 Details: 0.1 M Tris-HCl, pH 8.50, 25% PEG-4000, 8% 2-Methyl-2,4-pentanediol |
-Data collection
Diffraction | Mean temperature: 100 K / Serial crystal experiment: N |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: DECTRIS PILATUS 6M-F / Detector: PIXEL / Date: Jun 29, 2018 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 0.91587 Å / Relative weight: 1 |
Reflection | Resolution: 1.5→37.91 Å / Num. obs: 29582 / % possible obs: 99.4 % / Redundancy: 1.8 % / Biso Wilson estimate: 13.06 Å2 / CC1/2: 0.998 / Rmerge(I) obs: 0.026 / Rpim(I) all: 0.026 / Rrim(I) all: 0.036 / Χ2: 0.79 / Net I/σ(I): 16.8 / Num. measured all: 52858 |
Reflection shell | Resolution: 1.5→1.53 Å / % possible obs: 97.4 % / Redundancy: 1.5 % / Rmerge(I) obs: 0.084 / Num. measured all: 2228 / Num. unique obs: 1445 / CC1/2: 0.973 / Rpim(I) all: 0.084 / Rrim(I) all: 0.119 / Χ2: 1 / Net I/σ(I) obs: 6.8 |
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Processing
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Refinement | Method to determine structure: ![]() Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
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Solvent computation | Shrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | Biso mean: 17.7 Å2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 1.5→37.91 Å
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Refine LS restraints |
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LS refinement shell |
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