PDB-9bju: Crystal structure of the complex between VHL, ElonginB, ElonginC,...

ID or keywords:

Entry

Database: PDB / ID: 9bju

Title

Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5

Components

(von Hippel-Lindau disease tumor ...) x 2
3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE
Elongin-B
Elongin-C

Keywords

TRANSCRIPTION / VHL / degradation / degrader

Function / homology

Function and homology information

regulation of cellular response to hypoxia / RHOBTB3 ATPase cycle / negative regulation of receptor signaling pathway via JAK-STAT / transcription elongation factor activity / target-directed miRNA degradation / elongin complex / VCB complex / Replication of the SARS-CoV-1 genome / Cul5-RING ubiquitin ligase complex / Cul2-RING ubiquitin ligase complex ...regulation of cellular response to hypoxia / RHOBTB3 ATPase cycle / negative regulation of receptor signaling pathway via JAK-STAT / transcription elongation factor activity / target-directed miRNA degradation / elongin complex / VCB complex / Replication of the SARS-CoV-1 genome / Cul5-RING ubiquitin ligase complex / Cul2-RING ubiquitin ligase complex / intracellular non-membrane-bounded organelle / SUMOylation of ubiquitinylation proteins / negative regulation of transcription elongation by RNA polymerase II / Pausing and recovery of Tat-mediated HIV elongation / Tat-mediated HIV elongation arrest and recovery / HIV elongation arrest and recovery / Pausing and recovery of HIV elongation / ubiquitin-like ligase-substrate adaptor activity / Tat-mediated elongation of the HIV-1 transcript / Formation of HIV-1 elongation complex containing HIV-1 Tat / Formation of HIV elongation complex in the absence of HIV Tat / negative regulation of signal transduction / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / negative regulation of TORC1 signaling / RNA Polymerase II Pre-transcription Events / negative regulation of autophagy / transcription corepressor binding / transcription elongation by RNA polymerase II / positive regulation of cell differentiation / TP53 Regulates Transcription of DNA Repair Genes / transcription initiation at RNA polymerase II promoter / Vif-mediated degradation of APOBEC3G / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / cell morphogenesis / Inactivation of CSF3 (G-CSF) signaling / Evasion by RSV of host interferon responses / Regulation of expression of SLITs and ROBOs / ubiquitin-protein transferase activity / transcription corepressor activity / Antigen processing: Ubiquitination & Proteasome degradation / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / protein-macromolecule adaptor activity / Neddylation / Replication of the SARS-CoV-2 genome / cellular response to hypoxia / ubiquitin-dependent protein catabolic process / regulation of gene expression / protein-containing complex assembly / proteasome-mediated ubiquitin-dependent protein catabolic process / DNA-binding transcription factor binding / amyloid fibril formation / molecular adaptor activity / protein stabilization / protein ubiquitination / negative regulation of cell population proliferation / negative regulation of gene expression / ubiquitin protein ligase binding / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / enzyme binding / negative regulation of transcription by RNA polymerase II / endoplasmic reticulum / mitochondrion / proteolysis / nucleoplasm / nucleus / plasma membrane / cytosol
Similarity search - Function

Biological species

Homo sapiens (human)
synthetic construct (others)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 2.47 Å

Authors

Murray, J.M. / Wu, H. / Fuhrmann, J. / Fairbrother, W.J. / DiPasquale, A.

Funding support

1items

Citation

Journal: To Be Published
Title: Potency-enhanced peptidomimetic VHL ligands with improved oral bioavailability
Authors: Wu, H. / Murray, J.M. / Ishisoko, N. / Frommlet, A. / Fairbrother, W.J. / Fuhrmann, J.

History

Deposition	Apr 25, 2024	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	May 29, 2024	Provider: repository / Type: Initial release

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	9bju.cif.gz	570.6 KB	Display	PDBx/mmCIF format
PDB format	pdb9bju.ent.gz		Display	PDB format
PDBx/mmJSON format	9bju.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Summary document	9bju_validation.pdf.gz	598.6 KB	Display	wwPDB validaton report
Full document	9bju_full_validation.pdf.gz	611.1 KB	Display
Data in XML	9bju_validation.xml.gz	48.8 KB	Display
Data in CIF	9bju_validation.cif.gz	67.7 KB	Display
Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/bj/9bju ftp://data.pdbj.org/pub/pdb/validation_reports/bj/9bju	HTTPS FTP

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Related structure data

Related structure data	9bolC C: citing same article (ref.)
Similar structure data	Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#240 - Dec 2019 Hypoxia-Inducible Factors similarity (32) #110 - Feb 2009 Auxin and TIR1 Ubiquitin Ligase similarity (5) #60 - Dec 2004 Ubiquitin similarity (5) #218 - Feb 2018 EPSP Synthase and Weedkillers similarity (5) #234 - Jun 2019 MDM2 and Cancer similarity (2) #242 - Feb 2020 Coronavirus Proteases similarity (1) #205 - Jan 2017 Nuclear Pore Complex similarity (1) #67 - Jul 2005 TATA-Binding Protein similarity (1) #31 - Jul 2002 p53 Tumor Suppressor similarity (1) #249 - Sep 2020 SARS-CoV-2 RNA-dependent RNA Polymerase similarity (1) #47 - Nov 2003 Simian Virus 40 similarity (1) #122 - Feb 2010 Enhanceosome similarity (1) #213 - Sep 2017 Sirtuins similarity (1) #221 - May 2018 Human Papillomavirus and Vaccines similarity (1)

PDB pages

PDBj /

wwPDB /

NCBI

Related items in Molecule of the Month

#240 - Dec 2019
Hypoxia-Inducible Factors
similarity (32)
#110 - Feb 2009
Auxin and TIR1 Ubiquitin Ligase
similarity (5)
#60 - Dec 2004
Ubiquitin
similarity (5)
#218 - Feb 2018
EPSP Synthase and Weedkillers
similarity (5)
#234 - Jun 2019
MDM2 and Cancer
similarity (2)
#242 - Feb 2020
Coronavirus Proteases
similarity (1)
#205 - Jan 2017
Nuclear Pore Complex
similarity (1)
#67 - Jul 2005
TATA-Binding Protein
similarity (1)
#31 - Jul 2002
p53 Tumor Suppressor
similarity (1)
#249 - Sep 2020
SARS-CoV-2 RNA-dependent RNA Polymerase
similarity (1)
#47 - Nov 2003
Simian Virus 40
similarity (1)
#122 - Feb 2010
Enhanceosome
similarity (1)
#213 - Sep 2017
Sirtuins
similarity (1)
#221 - May 2018
Human Papillomavirus and Vaccines
similarity (1)

Deposited unit

A: Elongin-B

B: Elongin-C

C: von Hippel-Lindau disease tumor suppressor

D: Elongin-B

E: Elongin-C

F: von Hippel-Lindau disease tumor suppressor

G: Elongin-B

H: Elongin-C

I: von Hippel-Lindau disease tumor suppressor

J: Elongin-B

K: Elongin-C

L: von Hippel-Lindau disease tumor suppressor

W: 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE

X: 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE

Y: 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE

Z: 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE

hetero molecules

175 kDa, 16 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Elongin-B

B: Elongin-C

C: von Hippel-Lindau disease tumor suppressor

Z: 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE

hetero molecules

defined by author&software
Evidence: gel filtration
44 kDa, 4 polymers

2

D: Elongin-B

E: Elongin-C

F: von Hippel-Lindau disease tumor suppressor

Y: 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE

hetero molecules

defined by author&software
43.7 kDa, 4 polymers

3

G: Elongin-B

H: Elongin-C

I: von Hippel-Lindau disease tumor suppressor

X: 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE

hetero molecules

defined by author&software
43.8 kDa, 4 polymers

4

J: Elongin-B

K: Elongin-C

L: von Hippel-Lindau disease tumor suppressor

W: 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE

hetero molecules

defined by author&software
43.9 kDa, 4 polymers

Unit cell

Length a, b, c (Å)	93.297, 93.297, 362.757
Angle α, β, γ (deg.)	90.00, 90.00, 90.00
Int Tables number	91
Space group name H-M	P4₁22

Components on special symmetry positions

ID	Model	Components
1	1	F-404- HOH

Noncrystallographic symmetry (NCS)

NCS domain:
NCS ensembles :

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Protein , 2 types, 8 molecules ADGJBEHK

#1: Protein	Elongin-B / EloB / Elongin 18 kDa subunit / RNA polymerase II transcription factor SIII subunit B / SIII p18 / ...EloB / Elongin 18 kDa subunit / RNA polymerase II transcription factor SIII subunit B / SIII p18 / Transcription elongation factor B polypeptide 2 Mass: 11748.406 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: ELOB, TCEB2 / Production host: Escherichia coli (E. coli) / References: UniProt: Q15370
#2: Protein	Elongin-C / EloC / Elongin 15 kDa subunit / RNA polymerase II transcription factor SIII subunit C / SIII p15 / ...EloC / Elongin 15 kDa subunit / RNA polymerase II transcription factor SIII subunit C / SIII p15 / Transcription elongation factor B polypeptide 1 Mass: 10843.420 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: ELOC, TCEB1 / Production host: Escherichia coli (E. coli) / References: UniProt: Q15369

#1: Protein

Elongin-B / EloB / Elongin 18 kDa subunit / RNA polymerase II transcription factor SIII subunit B / SIII p18 / ...

Mass: 11748.406 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Homo sapiens (human) / Gene: ELOB, TCEB2 / Production host:

Escherichia coli (E. coli) / References: UniProt: Q15370

#2: Protein

Elongin-C / EloC / Elongin 15 kDa subunit / RNA polymerase II transcription factor SIII subunit C / SIII p15 / ...

Mass: 10843.420 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Homo sapiens (human) / Gene: ELOC, TCEB1 / Production host:

Escherichia coli (E. coli) / References: UniProt: Q15369

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Von Hippel-Lindau disease tumor ... , 2 types, 4 molecules CLFI

#3: Protein	von Hippel-Lindau disease tumor suppressor / Protein G7 / pVHL Mass: 20530.275 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: VHL / Production host: Escherichia coli (E. coli) / References: UniProt: P40337
#4: Protein	von Hippel-Lindau disease tumor suppressor / Protein G7 / pVHL Mass: 20514.275 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: VHL / Production host: Escherichia coli (E. coli) / References: UniProt: P40337

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Protein/peptide , 1 types, 4 molecules WXYZ

#5: Protein/peptide	3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE Mass: 491.603 Da / Num. of mol.: 4 / Source method: obtained synthetically / Source: (synth.) synthetic construct (others)

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Non-polymers , 6 types, 139 molecules

#6: Chemical	ChemComp-TFA / trifluoroacetic acid Mass: 114.023 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₂HF₃O₂
#7: Chemical	ChemComp-PEG / DI(HYDROXYETHYL)ETHER Mass: 106.120 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₄H₁₀O₃
#8: Chemical	ChemComp-EDO / 1,2-ETHANEDIOL / ETHYLENE GLYCOL Mass: 62.068 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₂H₆O₂
#9: Chemical	ChemComp-ACT / ACETATE ION Mass: 59.044 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: C₂H₃O₂
#10: Chemical	ChemComp-DMS / DIMETHYL SULFOXIDE Mass: 78.133 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: C₂H₆OS / Comment: DMSO, precipitant*YM
#11: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 128 / Source method: isolated from a natural source / Formula: H₂O

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Details

Has ligand of interest	Y

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.29 Å³/Da / Density % sol: 46.26 %
Crystal grow	Temperature: 277 K / Method: vapor diffusion, hanging drop Details: 0.1 mM sodium cacodylate pH 5.7, 15% PEG8000, 0.2 M magnesium acetate, 5 mM DTT

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Data collection

Diffraction

Mean temperature: 93 K / Serial crystal experiment: N

Diffraction source

Source:

SYNCHROTRON / Site:

SSRF

/ Beamline: BL19U1 / Wavelength: 0.97893 Å

Detector

Type: DECTRIS PILATUS3 6M / Detector: PIXEL / Date: May 17, 2018

Radiation

Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray

Radiation wavelength

Wavelength: 0.97893 Å / Relative weight: 1

Reflection

Resolution: 2.47→50 Å / Num. obs: 58657 / % possible obs: 99.9 % / Redundancy: 13.1 % / R_merge(I) obs: 0.136 / R_pim(I) all: 0.04 / R_rim(I) all: 0.142 / Χ²: 1.017 / Net I/σ(I): 4.5

Reflection shell

Diffraction-ID: 1

Resolution (Å)	Redundancy (%)	R_merge(I) obs	Num. unique obs	CC_1/2	CC star	R_pim(I) all	R_rim(I) all	Χ²	% possible all
2.47-2.56	12.5	1.228	5725	0.839	0.955	0.358	1.281	0.931	100
2.56-2.66	13.8	0.962	5761	0.924	0.98	0.266	0.999	0.944	100
2.66-2.78	13.7	0.71	5745	0.944	0.985	0.197	0.737	0.998	100
2.78-2.93	13.6	0.455	5796	0.979	0.995	0.127	0.473	1.079	100
2.93-3.11	13.2	0.307	5804	0.986	0.997	0.087	0.319	1.068	100
3.11-3.35	12.5	0.212	5789	0.986	0.996	0.062	0.221	1.052	100
3.35-3.69	13.8	0.16	5846	0.992	0.998	0.045	0.166	1.057	100
3.69-4.22	13.4	0.12	5906	0.991	0.998	0.035	0.125	1.039	100
4.22-5.32	12.5	0.102	5957	0.995	0.999	0.03	0.107	0.976	100
5.32-50	12.3	0.074	6328	0.989	0.997	0.023	0.078	1.016	99.6

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Processing

Software

Name	Version	Classification
REFMAC	5.8.0222	refinement
HKL-2000		data scaling
HKL-2000		data reduction
PHASER		phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT / Resolution: 2.47→48.86 Å / Cor.coef. F_o:F_c: 0.955 / Cor.coef. F_o:F_c free: 0.927 / SU B: 25.014 / SU ML: 0.264 / Cross valid method: THROUGHOUT / ESU R: 0.556 / ESU R Free: 0.289 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

	R_factor	Num. reflection	% reflection	Selection details
R_free	0.25565	2942	5 %	RANDOM
R_work	0.2184	-	-	-
obs	0.2203	55496	99.64 %	-

Solvent computation

Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK

Displacement parameters

B_iso mean: 66.929 Å²

	B_aniso -1	B_aniso -2	B_aniso -3
1-	1.7 Å²	0 Å²	0 Å²
2-	-	1.7 Å²	-0 Å²
3-	-	-	-3.39 Å²

Refinement step

Cycle: 1 / Resolution: 2.47→48.86 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	10799	0	201	128	11128

Refine LS restraints

Refine-ID	Type	Dev ideal	Dev ideal target	Number
X-RAY DIFFRACTION	r_bond_refined_d	0.01	0.014	11262
X-RAY DIFFRACTION	r_bond_other_d	0.001	0.017	10180
X-RAY DIFFRACTION	r_angle_refined_deg	1.374	1.69	15286
X-RAY DIFFRACTION	r_angle_other_deg	0.856	1.648	23920
X-RAY DIFFRACTION	r_dihedral_angle_1_deg	7.209	5	1328
X-RAY DIFFRACTION	r_dihedral_angle_2_deg	32.503	21.158	622
X-RAY DIFFRACTION	r_dihedral_angle_3_deg	16.506	15	1915
X-RAY DIFFRACTION	r_dihedral_angle_4_deg	20.007	15	100
X-RAY DIFFRACTION	r_chiral_restr	0.064	0.2	1466
X-RAY DIFFRACTION	r_gen_planes_refined	0.006	0.02	12442
X-RAY DIFFRACTION	r_gen_planes_other	0.001	0.02	1994
X-RAY DIFFRACTION	r_nbd_refined
X-RAY DIFFRACTION	r_nbd_other
X-RAY DIFFRACTION	r_nbtor_refined
X-RAY DIFFRACTION	r_nbtor_other
X-RAY DIFFRACTION	r_xyhbond_nbd_refined
X-RAY DIFFRACTION	r_xyhbond_nbd_other
X-RAY DIFFRACTION	r_metal_ion_refined
X-RAY DIFFRACTION	r_metal_ion_other
X-RAY DIFFRACTION	r_symmetry_vdw_refined
X-RAY DIFFRACTION	r_symmetry_vdw_other
X-RAY DIFFRACTION	r_symmetry_hbond_refined
X-RAY DIFFRACTION	r_symmetry_hbond_other
X-RAY DIFFRACTION	r_symmetry_metal_ion_refined
X-RAY DIFFRACTION	r_symmetry_metal_ion_other
X-RAY DIFFRACTION	r_mcbond_it	1.566	3.098	5360
X-RAY DIFFRACTION	r_mcbond_other	1.556	3.094	5356
X-RAY DIFFRACTION	r_mcangle_it	2.585	4.631	6670
X-RAY DIFFRACTION	r_mcangle_other	2.585	4.631	6671
X-RAY DIFFRACTION	r_scbond_it	1.721	3.334	5901
X-RAY DIFFRACTION	r_scbond_other	1.721	3.335	5902
X-RAY DIFFRACTION	r_scangle_it
X-RAY DIFFRACTION	r_scangle_other	2.628	4.933	8617
X-RAY DIFFRACTION	r_long_range_B_refined	5.245	35.8	11640
X-RAY DIFFRACTION	r_long_range_B_other	5.245	35.801	11641
X-RAY DIFFRACTION	r_rigid_bond_restr
X-RAY DIFFRACTION	r_sphericity_free
X-RAY DIFFRACTION	r_sphericity_bonded

Refine LS restraints NCS

Refine-ID: X-RAY DIFFRACTION / Type: interatomic distance / Weight position: 0.05

Ens-ID	Dom-ID	Auth asym-ID	Number	Rms dev position (Å)
1	1	A	3081	0.07
1	2	D	3081	0.07
2	1	A	3062	0.07
2	2	G	3062	0.07
3	1	A	3133	0.07
3	2	J	3133	0.07
4	1	B	2638	0.07
4	2	E	2638	0.07
5	1	B	2589	0.1
5	2	H	2589	0.1
6	1	B	2638	0.08
6	2	K	2638	0.08
7	1	C	4509	0.07
7	2	F	4509	0.07
8	1	C	4512	0.08
8	2	I	4512	0.08
9	1	C	4533	0.07
9	2	L	4533	0.07
10	1	D	3116	0.07
10	2	G	3116	0.07
11	1	D	3058	0.07
11	2	J	3058	0.07
12	1	E	2577	0.1
12	2	H	2577	0.1
13	1	E	2631	0.08
13	2	K	2631	0.08
14	1	F	4507	0.08
14	2	I	4507	0.08
15	1	F	4514	0.08
15	2	L	4514	0.08
16	1	G	3059	0.07
16	2	J	3059	0.07
17	1	H	2612	0.09
17	2	K	2612	0.09
18	1	I	4603	0.09
18	2	L	4603	0.09

LS refinement shell

Resolution: 2.473→2.537 Å / Total num. of bins used: 20

	R_factor	Num. reflection	% reflection
R_free	0.353	227	-
R_work	0.32	3987	-
obs	-	-	98.85 %

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	6.9993	0.2404	1.7421	0.3682	1.5045	7.7682	0.2545	-0.2885	0.2424	-0.1909	-0.1384	-0.1854	-0.4578	-0.0181	-0.1161	0.2148	0.1424	0.2142	0.2912	0.2124	0.3929	-19.3278	5.6943	38.6945
2	2.8168	-1.6412	-0.4245	4.0718	2.3034	5.5347	-0.0078	-0.3448	-0.3513	-0.1151	-0.2743	0.3795	0.2547	-0.3984	0.2821	0.1922	-0.0078	0.0996	0.1758	0.0161	0.2087	-24.6845	2.131	41.7004
3	8.2624	0.1937	2.6356	0.8663	1.9103	13.1514	0.0323	-0.3889	-1.2097	0.8911	0.135	-0.1101	1.4422	-0.7619	-0.1672	1.0056	0.1532	-0.0149	0.3889	0.0776	0.4316	-25.7142	-3.0699	49.2969
4	4.4063	2.226	4.2445	9.9964	0.7263	6.0846	0.2932	-0.51	0.1548	0.5156	-0.0682	-0.7833	0.093	0.373	-0.225	0.2353	-0.0087	0.1313	0.5876	-0.1938	0.3738	-20.2503	9.7862	50.2902
5	3.8141	-1.4147	-2.3419	5.7452	2.511	5.3919	0.3187	-0.4313	0.1723	0.1305	-0.1523	-0.3334	-0.7384	0.5151	-0.1664	0.2127	-0.0343	0.0399	0.2162	0.0169	0.1716	-16.3939	7.9743	40.0979
6	6.9748	-3.3253	-3.2802	15.522	-2.5938	2.7839	0.1552	0.084	0.1109	-0.4701	-0.1089	-0.0199	0.046	-0.0333	-0.0464	0.4953	0.014	0.0004	0.572	0.0124	0.5441	-24.1646	-9.9973	57.4295
7	1.0265	-2.9135	0.1551	10.7584	2.7894	4.242	-0.1019	-0.1007	-0.1046	0.4171	0.159	0.1874	0.1536	-0.153	-0.0571	0.4041	0.0695	0.0095	0.4374	0.0558	0.3819	-16.4633	-4.7914	53.1074
8	0.4344	-1.1238	-0.8816	6.1114	5.6475	5.3341	-0.1324	0.087	-0.4521	0.0748	0.0473	0.3578	-0.0241	0.1748	0.085	0.3094	-0.0751	0.1332	0.6511	0.0131	0.7421	-8.0032	-4.6869	41.102
9	2.2403	5.5564	-3.4635	14.247	-8.0829	6.0537	0.2352	-0.1476	-0.2309	0.5789	-0.1957	-0.7737	-0.1138	0.3343	-0.0395	0.3146	0.0118	-0.0592	0.5743	0.0439	0.695	4.7909	-2.9897	31.067
10	11.1411	-0.4039	9.3201	1.5632	-5.4862	25.14	0.1105	-0.1333	0.1482	0.0509	0.0803	0.0368	-0.0743	-0.0519	-0.1908	0.3526	-0.0127	0.0349	0.4907	-0.0852	0.5553	10.5504	0.7479	24.1766
11	5.4123	-1.367	1.5058	6.6222	1.1916	8.8813	-0.0382	0.0248	-0.8676	-0.1829	0.0178	0.5265	0.4936	-0.6478	0.0203	0.2799	-0.0077	0.1178	0.1446	-0.0169	0.3443	-19.1558	-7.8378	27.5104
12	2.3031	1.307	-0.7804	4.7597	2.4144	4.9365	0.0715	0.027	0.0151	-0.1804	0.1051	-0.0382	-0.514	0.1789	-0.1766	0.2888	0.0053	0.1256	0.0803	-0.0053	0.2155	-10.6636	3.856	24.5915
13	6.5336	-3.5746	4.7576	2.9087	-3.0119	7.9652	0.1062	0.329	0.0173	-0.208	0.1212	0.4333	-0.1591	-0.3081	-0.2274	0.705	-0.1109	0.1489	0.195	0.0461	0.4218	-11.8499	27.6698	5.2481
14	2.519	-0.9699	0.8798	4.7749	-2.3462	4.3915	0.058	0.1462	0.1197	-0.1897	0.0208	-0.0433	-0.3545	0.139	-0.0788	0.6	-0.0513	0.1951	0.1057	-0.0232	0.2929	-7.2186	25.4348	7.043
15	7.8232	-2.9494	-0.733	12.0805	2.7736	4.6956	0.4247	0.3004	0.1663	-0.9391	-0.3092	0.5719	-0.0482	-0.2291	-0.1155	0.5011	0.0013	0.0574	0.2891	0.0127	0.4238	-18.2064	26.0329	6.3728
16	0.9949	3.4371	-0.0481	12.0968	0.3722	2.363	0.0195	0.0562	0.4207	-0.1539	0.0659	1.2905	-0.5369	-0.5393	-0.0853	0.7149	0.1511	0.1398	0.2291	-0.0314	0.4614	-14.3996	22.5275	15.3486
17	10.7627	2.9511	-2.6623	6.5745	-2.3219	2.9806	0.0876	0.0547	0.459	-0.2208	0.223	-0.3377	-0.1905	0.3929	-0.3105	0.3762	-0.0367	0.1577	0.1247	-0.0856	0.2291	-2.6761	5.1026	18.1547
18	2.4609	1.5494	0.7264	7.0933	-0.8498	0.5584	0.3529	0.3018	-0.0752	0.4144	-0.3121	-0.2712	0.0435	0.3492	-0.0408	0.4087	-0.0101	0.0634	0.4689	-0.0443	0.4425	8.0306	-0.5865	15.1336
19	4.7826	5.0294	-1.671	7.3959	2.8303	11.0018	0.2484	0.0085	-0.4772	0.3301	0.0692	-0.7927	0.1678	0.5506	-0.3177	0.3777	0.0382	0.1294	0.4443	-0.0401	0.4708	0.6112	0.2867	9.6685
20	8.6264	3.733	3.9919	3.0655	0.4926	3.3684	-0.0173	0.0324	-0.2348	-0.1151	0.0153	0.0172	0.2404	-0.3749	0.002	0.563	0.0117	-0.0138	0.4685	-0.0314	0.5397	-10.8738	11.9025	-0.3295
21	3.7994	0.319	-0.3626	0.0373	0.1833	6.0735	-0.0375	0.0366	0.1309	0.0304	-0.0019	-0.0049	0.2338	-0.2372	0.0394	0.3867	-0.0576	0.0158	0.3548	-0.0092	0.3029	27.5982	2.3151	38.8883
22	2.7197	-3.1124	-1.2214	8.8553	3.5055	8.4353	-0.0515	-0.4108	-0.3011	0.2676	-0.0798	0.5729	1.0241	-0.7917	0.1313	0.4619	-0.1706	0.0456	0.3748	-0.0402	0.3393	25.48	-0.1331	39.493
23	3.9568	6.9685	-0.0458	12.6041	0.6769	8.8626	0.1408	-0.0535	0.0612	0.369	0.0342	0.4923	1.0774	-0.9655	-0.1751	0.6259	-0.3288	0.2099	0.8151	0.0614	0.7355	18.5223	-1.7707	44.3102
24	1.0216	-1.092	-1.2642	2.0326	-0.5129	6.351	-0.6016	0.0518	-0.621	1.0023	0.6895	1.0618	1.1873	-1.2322	-0.0879	1.4984	-0.2822	0.3815	0.8815	0.2512	0.6448	20.7223	-6.0737	49.5592
25	0.2246	0.4237	1.3688	3.6585	1.7063	8.9641	0.1458	-0.1348	0.0193	1.1277	-0.278	-0.0319	0.8999	-0.3845	0.1322	0.5714	-0.0141	0.1543	0.6699	-0.0869	0.4193	26.8011	6.527	50.4682
26	9.668	-1.0587	-1.8791	1.931	4.0524	8.5665	0.079	-0.5758	0.2788	0.1366	-0.079	-0.0284	0.318	-0.0658	0	0.4171	-0.051	0.018	0.336	-0.0057	0.2226	30.5165	4.3753	40.234
27	2.5745	5.0949	4.4192	16.2978	4.2564	10.8399	0.0847	0.1926	0.009	0.024	-0.0286	0.1495	0.1899	0.6721	-0.056	0.6343	0.0289	0.1105	0.5077	0.0648	0.6234	21.8438	-12.8391	57.7956
28	0.417	0.6394	-0.9794	1.4664	-3.2761	9.0553	-0.0063	-0.2749	-0.3732	0.15	-0.4161	-0.3825	-0.7633	0.3476	0.4224	0.74	0.1187	-0.0276	0.4761	-0.0039	0.6232	34.2302	-8.4785	47.2219
29	9.1189	3.8988	-0.5688	3.0473	-0.2965	0.0394	-0.082	-0.0487	-0.2499	-0.0767	0.0458	-0.3973	0.0215	0.0277	0.0363	0.5127	0.0502	-0.0406	0.5691	-0.0293	0.564	53.4035	-5.9261	27.8314
30	6.0028	2.3213	0.139	2.3347	3.113	6.558	-0.1482	0.0403	-0.3213	0.1996	-0.1824	0.0885	0.4671	-0.3846	0.3306	0.5371	-0.1122	0.0689	0.3667	0.012	0.5163	23.5218	-10.1529	31.4013
31	26.3877	-1.0196	-12.6972	4.6826	9.7081	24.5607	0.0773	0.0601	-0.535	0.6094	-0.349	-0.0063	1.227	-0.9423	0.2717	0.6406	-0.0022	-0.055	0.395	-0.0332	0.4607	36.3175	-14.6901	34.4981
32	5.0703	-0.9471	-5.0469	3.849	5.2657	10.1572	0.2897	0.4236	0.1233	0.2163	-0.441	0.2463	0.1776	-0.9073	0.1513	0.5635	-0.227	0	0.3532	-0.0593	0.4311	24.3497	-6.0272	28.5577
33	18.6418	0.322	-20.4375	0.01	-0.3587	22.4214	0.4701	1.22	0.3582	0.0619	0.0287	0.0428	-0.5516	-1.3506	-0.4988	0.8386	0.0651	0.1959	0.5853	0.1267	0.7303	26.6006	-11.2697	19.484
34	6.4268	0.5165	-9.073	13.1124	1.0541	13.0672	0.1367	0.0859	0.3784	-0.0759	0.3671	0.5086	-0.1601	-0.1462	-0.5038	0.5012	-0.0604	-0.0486	0.5406	-0.0132	0.6216	20.341	-15.3153	24.952
35	12.7388	-7.7	2.1587	10.0701	5.2216	8.2559	0.0167	0.3578	-1.4163	0.493	0.1142	0.8794	0.6652	0.3407	-0.1309	0.8906	-0.0832	-0.0342	0.4384	-0.0919	0.4986	33.5592	-16.0166	27.2429
36	3.0885	0.6935	0.0076	10.3779	-0.4873	8.6875	0.044	-0.0483	-0.1291	0.2438	-0.0598	-0.1829	0.7915	-0.4908	0.0158	0.3841	-0.0553	0.0267	0.1438	-0.0215	0.2073	32.6009	-0.6148	27.3088
37	1.503	2.5845	0.7885	5.8913	-2.353	10.2493	0.0213	-0.1277	0.3331	0.1495	-0.1243	0.546	-0.5244	-0.5685	0.1031	0.557	-0.0067	0.1279	0.4116	-0.0602	0.3292	33.9431	9.3866	23.7915
38	6.9865	3.3199	1.662	3.3699	2.9539	3.2498	0.194	-0.1853	-0.0705	0.3888	-0.0392	-0.285	0.537	0.1437	-0.1548	0.444	0.031	-0.0013	0.2585	0.011	0.3624	41.3141	-6.4195	22.3684
39	6.7193	-1.4125	-2.4158	0.3207	0.4251	1.3299	0.369	0.7796	-0.1707	-0.0378	-0.2684	0.065	-0.4744	-0.0755	-0.1006	0.8824	0.0491	0.0011	0.6958	0.0072	0.5594	31.8003	23.4377	-5.5491
40	2.7268	-2.0377	0.8483	4.9421	-1.9725	4.9439	0.2152	0.1365	0.2758	-0.349	-0.0774	-0.0428	-1.1822	-0.206	-0.1378	0.8662	-0.0277	0.1301	0.1809	-0.0458	0.3798	38.7037	23.3319	7.9413
41	11.3002	-6.2651	3.7666	8.5293	-3.0697	3.511	0.3259	0.305	0.1326	-0.5771	-0.1684	0.3147	-0.2449	-0.122	-0.1575	0.6369	0.0084	0.0725	0.1827	-0.0546	0.3796	33.3209	17.9333	9.2783
42	0.7268	0.1404	0.6208	0.0878	-0.3048	3.5011	-0.2887	-0.0737	0.7394	-0.0054	0.1053	0.2069	-0.5771	-0.9273	0.1834	1.0406	0.0951	0.0818	0.26	0.0432	0.9345	30.5386	20.9761	14.6272
43	6.7219	1.4816	-4.7684	11.2789	3.2896	8.1174	0.1953	-0.2365	-0.0475	0.1849	0.2785	-0.6329	-0.0953	0.709	-0.4739	0.3172	-0.0454	0.0376	0.1569	-0.0446	0.3241	43.8939	1.0484	18.3108
44	10.6783	1.485	-1.5948	9.0881	-2.3405	0.7962	0.7036	0.0845	0.0129	0.5787	-0.9586	-1.221	-0.1251	0.4194	0.255	0.568	0.1006	-0.0464	0.9488	-0.1331	0.7366	54.6764	-4.8658	15.3649
45	2.6769	1.1703	-0.634	7.6182	1.3731	2.5333	0.0863	0.0966	-0.0752	0.1503	-0.1441	-0.4964	0.1197	0.3623	0.0577	0.4178	0.045	0.0071	0.3405	-0.054	0.3895	47.0828	-3.7965	9.7776
46	8.1869	2.0158	2.0927	8.4994	0.026	1.9758	-0.7248	0.4933	-0.645	-0.0437	0.7106	0.0402	0.1825	-0.5787	0.0142	0.7637	-0.0257	0.0096	0.5973	-0.0128	0.6764	35.8343	7.7258	-0.1305
47	3.5976	1.8157	0.0889	1.9777	-2.9681	8.6511	-0.2378	-0.1265	0.5214	0.0268	0.2037	0.2511	-0.2113	-0.8663	0.0341	0.4626	-0.0231	0.0763	0.3037	0.0079	0.2467	31.3989	47.6653	38.9966
48	2.7041	-3.1249	-0.1718	8.7456	-0.4241	4.6401	-0.2624	-0.144	-0.4239	0.2409	0.2604	1.2461	0.2668	-0.8168	0.002	0.4519	-0.094	0.0899	0.3982	0.0674	0.4211	26.5993	43.5845	42.3625
49	3.6352	-2.5275	-3.0117	7.4939	-2.5595	6.3427	-0.662	0.0821	-0.6767	0.8882	0.7005	1.1942	0.4239	-0.7662	-0.0385	0.8036	-0.0932	0.1529	0.5041	0.0846	0.4318	26.6702	38.1442	49.9978
50	8.6151	-3.4061	5.1635	4.0003	-3.0091	9.4653	-0.3637	-0.153	0.7653	0.8266	0.224	-0.431	-0.3778	-0.7564	0.1396	0.6683	0.0538	0.0394	0.4091	-0.0767	0.4171	31.0242	51.5187	50.7528
51	4.8141	1.7628	-2.2705	0.7106	-1.5904	10.4734	0.0013	-0.2772	0.3878	0.0427	-0.0812	0.1426	-0.4266	-0.3126	0.0799	0.4204	0.0063	0.0885	0.2578	0.0091	0.2538	34.1834	50.0116	40.1342
52	5.4322	-0.0919	8.2796	9.3718	4.5109	14.9283	-0.485	-0.318	-0.1962	0.8667	0.5354	0.5207	-0.3162	-0.2186	-0.0504	0.4803	0.0146	0.0612	0.4461	0.0259	0.4698	29.9794	30.9793	57.6667
53	2.7821	3.4142	-4.9847	4.4531	-5.5673	10.5804	-0.1819	-0.2694	-0.392	-0.1173	-0.6157	-0.3043	0.0107	-0.1225	0.7977	0.6471	0.0257	0.1093	0.4358	-0.0132	0.3857	40.0648	37.6756	46.2597
54	5.5157	1.0531	-3.3109	0.6344	-0.3493	2.1775	0.5936	-0.2114	0.0117	0.3125	-0.1837	-0.5663	-0.2579	0.1105	-0.4099	0.793	0.0417	0.0231	0.5979	0.2615	0.8739	57.0431	42.3995	25.169
55	5.5224	-0.5969	0.4973	5.9519	-0.7737	6.5048	0.0791	0.3181	-0.5235	-0.6021	0.0846	1.0199	0.8664	-1.1897	-0.1637	0.8171	-0.1725	0.0101	0.3744	0.0067	0.4154	29.936	35.2694	27.8428
56	2.7254	-0.3321	0.2824	5.4069	-0.5488	2.2699	0.1417	0.1085	-0.022	-0.5873	-0.1168	0.039	0.4439	-0.2189	-0.0249	0.613	-0.0281	0.0661	0.1264	0.034	0.2411	36.982	42.2056	26.6278
57	3.5397	4.3728	2.2943	11.2739	2.1025	7.9728	-0.406	0.4274	0.0501	0.1008	0.2256	1.2079	-0.3824	-0.7219	0.1804	0.5595	-0.0243	0.1533	0.3753	-0.0378	0.3251	35.3951	55.5668	23.6916
58	11.2306	3.5855	4.6862	3.9561	3.3131	7.3096	-0.0809	0.0997	-0.1003	-0.1226	0.0573	-0.124	0.3255	0.2244	0.0237	0.4778	0.0225	0.0454	0.2219	0.0588	0.3373	44.2649	40.7845	21.0415
59	4.4129	-3.2656	2.2903	7.0442	-3.0006	5.256	-0.3303	0.2463	0.2234	-0.0763	0.0109	0.1203	-0.2891	-0.4174	0.3193	0.3076	-0.084	0.0631	0.122	-0.0027	0.3421	34.2727	70.7592	5.5671
60	2.9424	-0.5592	0.5106	5.2646	-1.938	3.2497	-0.1298	0.1432	0.0795	-0.1718	-0.0373	0.1128	0.2113	-0.121	0.1671	0.4543	-0.0195	0.0464	0.1008	-0.0202	0.2411	37.3494	68.7707	7.0901
61	2.3606	0.3282	0.6015	5.4737	-1.4013	3.4758	-0.0341	0.0225	-0.2035	-0.3504	-0.1897	-0.3818	0.36	0.4026	0.2238	0.5834	-0.0547	0.0862	0.1593	0.0223	0.1629	43.5912	53.9188	14.8536
62	1.8376	1.6917	1.9927	11.3959	-5.2192	7.3105	0.0356	0.1671	-0.7109	0.0308	0.503	-0.9673	0.3652	-0.0527	-0.5386	0.8926	0.1254	0.1223	0.2329	-0.0165	0.5069	48.489	44.126	8.1375
63	8.0508	3.9366	4.2492	5.0101	0.6978	2.978	-0.0197	0.0827	0.1565	-0.1212	-0.0105	0.3972	0.109	-0.1726	0.0301	0.4857	-0.0231	0.0273	0.5426	-0.0899	0.4819	35.1791	54.8639	-1.1484
64	5.425	-1.037	3.5253	0.4985	-2.2191	10.4329	0.1242	-0.2593	0.3132	-0.1953	0.1666	0.0345	0.767	-0.9052	-0.2909	0.37	-0.0815	0.0427	0.2296	-0.0168	0.1841	-16.1118	51.5547	38.6859
65	4.3999	-1.2144	-1.0561	1.0707	2.4184	6.571	-0.1564	-0.3462	-0.5913	0.1593	-0.2416	0.2959	0.5394	-0.9246	0.398	0.374	-0.1882	0.0693	0.3791	0.0019	0.2863	-21.0947	47.6381	41.8739
66	12.7625	4.7079	-0.853	10.8071	1.1252	0.3136	0.0486	-0.425	-0.0423	1.0685	-0.153	0.7512	0.2954	-0.0274	0.1044	0.8213	-0.2158	0.1666	0.4194	0.123	0.2861	-21.4327	42.1734	49.4993
67	6.4766	-2.4337	3.3262	7.7595	-3.8257	5.6947	-0.3051	-0.2019	0.4957	0.7712	0.0906	-0.4606	-0.0851	-0.0125	0.2145	0.2668	-0.0417	0.0652	0.4262	-0.111	0.3277	-16.5336	55.3253	50.402
68	3.6371	0.122	-0.6244	2.3524	0.7422	11.0021	0.0604	-0.1741	0.172	0.0389	-0.2525	0.0023	-0.147	0.2537	0.1921	0.1392	-0.0442	0.1013	0.1726	0.0078	0.1681	-13.2009	53.844	39.8904
69	9.2394	-0.8043	4.3711	5.4558	-3.1339	3.477	0.0099	-0.7022	-0.2396	0.1054	0.103	0.0169	-0.0582	-0.3802	-0.1128	0.6328	-0.0164	0.0486	0.589	-0.0285	0.4896	-18.4275	35.0991	57.3006
70	0.0445	-0.2111	-0.2954	3.0093	0.783	9.5695	-0.1671	-0.0365	-0.0432	0.2639	-0.4127	-0.2665	1.6213	-0.3451	0.5798	0.7511	0.0805	0.1096	0.4246	0.1339	0.2861	-8.0452	41.2263	46.1922
71	4.6765	4.4682	-6.3815	4.4198	-5.9947	8.7942	0.5166	-0.2255	0.113	0.6664	-0.2193	-0.1769	-0.5174	0.3427	-0.2973	0.5681	0.052	-0.089	0.4808	0.0775	0.7086	7.384	44.5563	29.3026
72	5.1405	4.5582	8.496	4.0488	7.533	14.0448	-0.2256	0.4008	-0.0332	-0.225	0.3083	-0.0665	-0.3852	0.6903	-0.0827	0.4764	0.0265	0.108	0.5405	0.0085	0.5836	12.6145	48.7052	21.8788
73	3.1613	-0.6248	0.9615	9.5555	0.4674	2.9828	-0.1921	-0.4415	0.0514	0.2759	-0.0066	0.3194	0.2382	-0.4248	0.1987	0.4717	-0.0573	0.0299	0.2617	0.0197	0.2853	-19.3903	38.9365	31.3565
74	5.9526	3.0586	-0.1467	4.1458	4.6015	8.6919	0.1232	0.3234	-0.3204	0.3614	-0.5277	0.1625	0.8777	-1.2787	0.4045	0.8988	-0.1279	-0.1265	0.2318	0.0167	0.3889	-16.7909	40.8151	26.5726
75	12.3045	1.3664	3.3791	4.5782	1.1095	1.0627	0.0135	0.258	-0.5821	-0.1173	0.0641	0.1415	0.01	0.0375	-0.0777	0.4895	-0.002	0.017	0.3262	0.0011	0.3805	-13.4221	34.2576	25.6767
76	3.1729	-4.4997	-0.1212	11.281	-1.4183	4.1488	-0.0547	-0.2165	0.1514	-0.3787	0.0764	-0.053	0.5627	-0.1372	-0.0217	0.3115	-0.0737	0.0838	0.1202	0.0366	0.1959	-11.7614	49.4634	26.7481
77	3.8576	4.5845	4.1231	8.1883	1.4302	8.8683	-0.2325	-0.1124	0.4708	-0.3731	-0.0879	0.7339	-0.0697	-0.283	0.3204	0.3093	-0.057	0.0919	0.1983	-0.017	0.196	-11.6612	59.5493	23.5281
78	11.3088	3.8965	2.7781	4.622	3.4474	6.065	0.1394	-0.0347	-0.217	-0.0767	-0.1301	-0.2922	0.5516	0.3525	-0.0093	0.4168	0.0457	0.0646	0.1428	0.0937	0.265	-3.0875	44.5265	21.049
79	5.5695	-3.3933	2.1782	6.2571	-1.7832	4.0322	-0.0641	0.3155	0.2812	-0.1437	-0.0013	0.5902	-0.4967	-0.0225	0.0655	0.2693	-0.0593	0.05	0.0619	-0.0128	0.3339	-12.2403	75.2067	6.0655
80	3.5071	-1.3604	-0.0753	2.7059	-0.9224	3.6308	-0.0086	0.0688	0.1335	-0.2883	-0.0567	-0.0227	-0.0562	-0.0773	0.0653	0.2344	-0.0178	0.0951	0.0083	-0.0206	0.2056	-7.3557	72.8151	7.0601
81	7.0747	0.3674	1.1812	0.083	0.2585	6.4385	-0.1234	-0.0549	0.7303	-0.018	0.0113	0.2148	-0.3205	-0.9524	0.1121	0.4377	-0.0182	0.0351	0.2146	0.0609	0.6364	-18.6622	76.2541	9.4707
82	7.7341	-1.474	-0.8725	2.7013	0.7709	3.1275	-0.034	0.2055	-0.2232	-0.1136	-0.064	-0.534	0.2461	0.5695	0.098	0.3926	0.0417	0.0997	0.1379	0.0666	0.2477	1.18	51.4701	15.4905
83	0.1272	-0.9772	0.8677	13.2854	-11.6822	10.2791	0.0709	0.0896	-0.1221	0.0619	-0.4878	-0.5147	-0.0717	0.4644	0.4169	0.6519	0.0927	0.0706	0.2198	-0.1403	0.6204	1.5274	47.7853	8.3343
84	18.3606	4.4449	8.3784	5.5883	-0.3891	5.5806	-0.1319	0.2668	-0.1207	-0.1753	0.2485	0.4131	0.0275	-0.3853	-0.1166	0.4543	0.0281	0.0757	0.3952	-0.0693	0.3685	-11.475	58.9303	-1.5682

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	A	1 - 9
2	X-RAY DIFFRACTION	2	A	10 - 35
3	X-RAY DIFFRACTION	3	A	36 - 45
4	X-RAY DIFFRACTION	4	A	46 - 60
5	X-RAY DIFFRACTION	5	A	61 - 79
6	X-RAY DIFFRACTION	6	A	80 - 84
7	X-RAY DIFFRACTION	7	A	85 - 89
8	X-RAY DIFFRACTION	8	A	90 - 94
9	X-RAY DIFFRACTION	9	A	95 - 99
10	X-RAY DIFFRACTION	10	A	100 - 104
11	X-RAY DIFFRACTION	11	B	17 - 66
12	X-RAY DIFFRACTION	12	B	67 - 112
13	X-RAY DIFFRACTION	13	C	61 - 83
14	X-RAY DIFFRACTION	14	C	84 - 131
15	X-RAY DIFFRACTION	15	C	132 - 141
16	X-RAY DIFFRACTION	16	C	145 - 157
17	X-RAY DIFFRACTION	17	C	158 - 169
18	X-RAY DIFFRACTION	18	C	170 - 181
19	X-RAY DIFFRACTION	19	C	182 - 193
20	X-RAY DIFFRACTION	20	C	194 - 205
21	X-RAY DIFFRACTION	21	D	1 - 9
22	X-RAY DIFFRACTION	22	D	10 - 23
23	X-RAY DIFFRACTION	23	D	24 - 35
24	X-RAY DIFFRACTION	24	D	36 - 45
25	X-RAY DIFFRACTION	25	D	46 - 60
26	X-RAY DIFFRACTION	26	D	61 - 79
27	X-RAY DIFFRACTION	27	D	80 - 84
28	X-RAY DIFFRACTION	28	D	85 - 94
29	X-RAY DIFFRACTION	29	D	95 - 103
30	X-RAY DIFFRACTION	30	E	17 - 22
31	X-RAY DIFFRACTION	31	E	23 - 27
32	X-RAY DIFFRACTION	32	E	28 - 38
33	X-RAY DIFFRACTION	33	E	39 - 45
34	X-RAY DIFFRACTION	34	E	46 - 58
35	X-RAY DIFFRACTION	35	E	59 - 66
36	X-RAY DIFFRACTION	36	E	67 - 83
37	X-RAY DIFFRACTION	37	E	84 - 96
38	X-RAY DIFFRACTION	38	E	97 - 112
39	X-RAY DIFFRACTION	39	F	62 - 70
40	X-RAY DIFFRACTION	40	F	71 - 121
41	X-RAY DIFFRACTION	41	F	122 - 141
42	X-RAY DIFFRACTION	42	F	142 - 157
43	X-RAY DIFFRACTION	43	F	158 - 169
44	X-RAY DIFFRACTION	44	F	170 - 181
45	X-RAY DIFFRACTION	45	F	182 - 193
46	X-RAY DIFFRACTION	46	F	194 - 205
47	X-RAY DIFFRACTION	47	G	1 - 9
48	X-RAY DIFFRACTION	48	G	10 - 35
49	X-RAY DIFFRACTION	49	G	36 - 45
50	X-RAY DIFFRACTION	50	G	46 - 60
51	X-RAY DIFFRACTION	51	G	61 - 79
52	X-RAY DIFFRACTION	52	G	80 - 84
53	X-RAY DIFFRACTION	53	G	85 - 94
54	X-RAY DIFFRACTION	54	G	95 - 103
55	X-RAY DIFFRACTION	55	H	17 - 61
56	X-RAY DIFFRACTION	56	H	62 - 83
57	X-RAY DIFFRACTION	57	H	84 - 96
58	X-RAY DIFFRACTION	58	H	97 - 112
59	X-RAY DIFFRACTION	59	I	61 - 83
60	X-RAY DIFFRACTION	60	I	84 - 141
61	X-RAY DIFFRACTION	61	I	142 - 181
62	X-RAY DIFFRACTION	62	I	182 - 193
63	X-RAY DIFFRACTION	63	I	194 - 207
64	X-RAY DIFFRACTION	64	J	1 - 9
65	X-RAY DIFFRACTION	65	J	10 - 35
66	X-RAY DIFFRACTION	66	J	36 - 45
67	X-RAY DIFFRACTION	67	J	46 - 60
68	X-RAY DIFFRACTION	68	J	61 - 79
69	X-RAY DIFFRACTION	69	J	80 - 84
70	X-RAY DIFFRACTION	70	J	85 - 94
71	X-RAY DIFFRACTION	71	J	95 - 99
72	X-RAY DIFFRACTION	72	J	100 - 104
73	X-RAY DIFFRACTION	73	K	17 - 22
74	X-RAY DIFFRACTION	74	K	23 - 45
75	X-RAY DIFFRACTION	75	K	46 - 66
76	X-RAY DIFFRACTION	76	K	67 - 83
77	X-RAY DIFFRACTION	77	K	84 - 96
78	X-RAY DIFFRACTION	78	K	97 - 112
79	X-RAY DIFFRACTION	79	L	62 - 83
80	X-RAY DIFFRACTION	80	L	84 - 131
81	X-RAY DIFFRACTION	81	L	132 - 151
82	X-RAY DIFFRACTION	82	L	152 - 181
83	X-RAY DIFFRACTION	83	L	182 - 193
84	X-RAY DIFFRACTION	84	L	194 - 207

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