登録情報 | データベース: PDB / ID: 9bc7 |
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タイトル | HCN1 M305L holo |
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要素 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
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キーワード | MEMBRANE PROTEIN / nanodisc / TRANSPORT PROTEIN |
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機能・相同性 | 機能・相同性情報
intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential / HCN channels / general adaptation syndrome, behavioral process / HCN channel complex / retinal cone cell development / regulation of membrane depolarization / intracellularly cAMP-activated cation channel activity / apical protein localization / voltage-gated monoatomic cation channel activity / voltage-gated sodium channel activity ...intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential / HCN channels / general adaptation syndrome, behavioral process / HCN channel complex / retinal cone cell development / regulation of membrane depolarization / intracellularly cAMP-activated cation channel activity / apical protein localization / voltage-gated monoatomic cation channel activity / voltage-gated sodium channel activity / voltage-gated potassium channel activity / potassium channel activity / sodium ion transmembrane transport / neuronal action potential / cAMP binding / cellular response to cAMP / presynaptic active zone membrane / potassium ion transmembrane transport / regulation of membrane potential / postsynaptic membrane / protein homotetramerization / axon / glutamatergic synapse / dendrite / identical protein binding / plasma membrane類似検索 - 分子機能 Ion transport N-terminal / Ion transport protein N-terminal / Potassium channel, voltage-dependent, EAG/ELK/ERG / Cyclic nucleotide-binding domain signature 1. / Cyclic nucleotide-binding, conserved site / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain / Cyclic nucleotide-binding domain superfamily ...Ion transport N-terminal / Ion transport protein N-terminal / Potassium channel, voltage-dependent, EAG/ELK/ERG / Cyclic nucleotide-binding domain signature 1. / Cyclic nucleotide-binding, conserved site / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain / Cyclic nucleotide-binding domain superfamily / RmlC-like jelly roll fold / Ion transport domain / Ion transport protein類似検索 - ドメイン・相同性 ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE / 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.3 Å |
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データ登録者 | Kim, E.D. / Nimigean, C.M. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM124451 | 米国 | National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) | NS137561 | 米国 |
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引用 | ジャーナル: Nature / 年: 2024 タイトル: Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants 著者: Kim, E.D. / Wu, X. / Lee, S. / Tibbs, G.R. / Cunningham, K.P. / Di Zanni, E. / Perez, M.E. / Goldstein, P.A. / Accardi, A. / Larsson, H.P. / Nimigean, C.M. |
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履歴 | 登録 | 2024年4月8日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2024年7月31日 | Provider: repository / タイプ: Initial release |
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