登録情報 データベース : PDB / ID : 9avs 構造の表示 ダウンロードとリンクタイトル Human alpha-galactosidase A in complex with saposin B 要素Alpha-galactosidase A Saposin-B 詳細キーワード HYDROLASE / Galactosidase / GLA / Saposin / SapB / Fabry disease / Lysosomal / Activator protein機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of beta-galactosidase activity / ganglioside GM1 transport to membrane / ganglioside GM2 binding / ganglioside GM3 binding / ganglioside GP1c binding / glycosylceramide catabolic process / ganglioside GM1 binding / negative regulation of nitric-oxide synthase activity / ganglioside GT1b binding / alpha-galactosidase ... positive regulation of beta-galactosidase activity / ganglioside GM1 transport to membrane / ganglioside GM2 binding / ganglioside GM3 binding / ganglioside GP1c binding / glycosylceramide catabolic process / ganglioside GM1 binding / negative regulation of nitric-oxide synthase activity / ganglioside GT1b binding / alpha-galactosidase / alpha-galactosidase activity / glycosphingolipid catabolic process / oligosaccharide metabolic process / glycoside catabolic process / galactoside binding / sphingolipid metabolic process / negative regulation of nitric oxide biosynthetic process / prostate gland growth / epithelial cell differentiation involved in prostate gland development / Glycosphingolipid catabolism / lysosomal transport / azurophil granule membrane / regulation of lipid metabolic process / catalytic activity / enzyme activator activity / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / lysosomal lumen / Peptide ligand-binding receptors / regulation of autophagy / phospholipid binding / azurophil granule lumen / late endosome / Platelet degranulation / G alpha (i) signalling events / scaffold protein binding / collagen-containing extracellular matrix / protease binding / lysosome / hydrolase activity / lysosomal membrane / intracellular membrane-bounded organelle / signaling receptor binding / Neutrophil degranulation / Golgi apparatus / protein homodimerization activity / extracellular space / extracellular exosome / extracellular region / identical protein binding / plasma membrane / cytoplasm 類似検索 - 分子機能 Saposin, chordata / Alpha galactosidase A, C-terminal beta-sandwich domain / Alpha galactosidase A C-terminal beta sandwich domain / Saposin A-type domain / Saposin / Saposin A-type domain / Saposin A-type domain profile. / Saposin/surfactant protein-B A-type DOMAIN / Saposin-like type B, region 1 / Saposin-like type B, region 1 ... Saposin, chordata / Alpha galactosidase A, C-terminal beta-sandwich domain / Alpha galactosidase A C-terminal beta sandwich domain / Saposin A-type domain / Saposin / Saposin A-type domain / Saposin A-type domain profile. / Saposin/surfactant protein-B A-type DOMAIN / Saposin-like type B, region 1 / Saposin-like type B, region 1 / Saposin B type, region 2 / Alpha galactosidase A / Glycoside hydrolase, family 27 / Saposin-like type B, region 2 / Saposin (B) Domains / Saposin B type domain / Saposin-like / Saposin B type domain profile. / Glycoside hydrolase family 27/36, conserved site / Alpha-galactosidase signature. / Glycosyl hydrolase, all-beta / Aldolase-type TIM barrel / Glycoside hydrolase superfamily 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.53 Å 詳細データ登録者 Sawyer, T.K. / Garman, S.C. 資金援助 米国, 1件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) 5R01DK076877 米国
引用ジャーナル : Biorxiv / 年 : 2024タイトル : Human Saposin B Ligand Binding and Presentation to alpha-Galactosidase A.著者 : Sawyer, T.K. / Aral, E. / Staros, J.V. / Bobst, C.E. / Garman, S.C. 履歴 登録 2024年3月4日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2024年4月17日 Provider : repository / タイプ : Initial release改定 1.1 2024年4月24日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.pdbx_database_id_PubMed / _citation.title ... _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name
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