登録情報 | データベース: PDB / ID: 8x8t |
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タイトル | NMR structure of p75NTR juxtamembrane domain in complex with RhoGDI N-terminal domain containing a phosphorylation-mimicking S34D mutation |
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要素 | - Rho GDP-dissociation inhibitor 1
- Tumor necrosis factor receptor superfamily member 16
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キーワード | SIGNALING PROTEIN / Inhibitor / Complex / Signaling |
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機能・相同性 | 機能・相同性情報
NFG and proNGF binds to p75NTR / detection of temperature stimulus / dorsal aorta development / Ceramide signalling / death receptor activity / Rho GDP-dissociation inhibitor activity / positive regulation of odontogenesis of dentin-containing tooth / negative regulation of hair follicle development / negative regulation of fibroblast growth factor receptor signaling pathway / p75NTR negatively regulates cell cycle via SC1 ...NFG and proNGF binds to p75NTR / detection of temperature stimulus / dorsal aorta development / Ceramide signalling / death receptor activity / Rho GDP-dissociation inhibitor activity / positive regulation of odontogenesis of dentin-containing tooth / negative regulation of hair follicle development / negative regulation of fibroblast growth factor receptor signaling pathway / p75NTR negatively regulates cell cycle via SC1 / negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / neurotrophin binding / regulation of synaptic vesicle cycle / nerve development / Axonal growth inhibition (RHOA activation) / Axonal growth stimulation / nerve growth factor binding / NADE modulates death signalling / Regulated proteolysis of p75NTR / regulation of Rho protein signal transduction / hair follicle morphogenesis / NRAGE signals death through JNK / RHOC GTPase cycle / intracellular glucose homeostasis / odontogenesis of dentin-containing tooth / CDC42 GTPase cycle / RHOH GTPase cycle / semaphorin-plexin signaling pathway / Rho protein signal transduction / immunological synapse / RHOG GTPase cycle / RHOA GTPase cycle / RAC2 GTPase cycle / fibroblast growth factor receptor signaling pathway / coreceptor activity / RAC1 GTPase cycle / p75NTR recruits signalling complexes / presynaptic modulation of chemical synaptic transmission / NF-kB is activated and signals survival / NRIF signals cell death from the nucleus / negative regulation of cell migration / GTPase activator activity / central nervous system development / positive regulation of apoptotic signaling pathway / axon guidance / intracellular protein transport / circadian regulation of gene expression / Schaffer collateral - CA1 synapse / neuromuscular junction / small GTPase binding / positive regulation of miRNA transcription / positive regulation of protein localization to nucleus / cellular response to amyloid-beta / transmembrane signaling receptor activity / activation of cysteine-type endopeptidase activity involved in apoptotic process / regulation of protein localization / positive regulation of fibroblast proliferation / cell-cell junction / presynapse / glucose homeostasis / signaling receptor activity / amyloid-beta binding / growth cone / fibroblast proliferation / perikaryon / neuron apoptotic process / dendritic spine / postsynaptic density / cytoskeleton / calmodulin binding / endosome / ubiquitin protein ligase binding / negative regulation of apoptotic process / cell surface / extracellular exosome / extracellular region / nucleoplasm / membrane / nucleus / plasma membrane / cytosol類似検索 - 分子機能 Tumour necrosis factor receptor 16 / Tumor necrosis factor receptor 16, N-terminal / Tumor necrosis factor receptor member 16, transmembrane domain / Tumor necrosis factor receptor member 16 trans-membrane domain / Rho protein GDP-dissociation inhibitor / Rho GDP-dissociation inhibitor domain superfamily / RHO protein GDP dissociation inhibitor / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. ...Tumour necrosis factor receptor 16 / Tumor necrosis factor receptor 16, N-terminal / Tumor necrosis factor receptor member 16, transmembrane domain / Tumor necrosis factor receptor member 16 trans-membrane domain / Rho protein GDP-dissociation inhibitor / Rho GDP-dissociation inhibitor domain superfamily / RHO protein GDP dissociation inhibitor / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Death-like domain superfamily / Immunoglobulin E-set類似検索 - ドメイン・相同性 Tumor necrosis factor receptor superfamily member 16 / Rho GDP-dissociation inhibitor 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / torsion angle dynamics |
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データ登録者 | Lin, Z. / Li, Z. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | | 中国 |
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引用 | ジャーナル: Embo Rep. / 年: 2024 タイトル: RhoGDI phosphorylation by PKC promotes its interaction with death receptor p75 NTR to gate axon growth and neuron survival. 著者: Ramanujan, A. / Li, Z. / Ma, Y. / Lin, Z. / Ibanez, C.F. |
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履歴 | 登録 | 2023年11月28日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2024年4月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年5月15日 | Group: Database references / カテゴリ: database_2 / Item: _database_2.pdbx_DOI |
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