登録情報 | データベース: PDB / ID: 8vjf |
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タイトル | Human R14A Pin1 covalently bound to inhibitor 158D9 |
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要素 | - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
- inhibitor 158D9
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キーワード | ISOMERASE/INHIBITOR / Destabilizing Inhibitor / PPIase / Structure-Activity Relationship / Drug Design / ISOMERASE / ISOMERASE-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
cis-trans isomerase activity / phosphothreonine residue binding / negative regulation of cell motility / ubiquitin ligase activator activity / regulation of protein localization to nucleus / GTPase activating protein binding / protein targeting to mitochondrion / protein peptidyl-prolyl isomerization / mitogen-activated protein kinase kinase binding / regulation of mitotic nuclear division ...cis-trans isomerase activity / phosphothreonine residue binding / negative regulation of cell motility / ubiquitin ligase activator activity / regulation of protein localization to nucleus / GTPase activating protein binding / protein targeting to mitochondrion / protein peptidyl-prolyl isomerization / mitogen-activated protein kinase kinase binding / regulation of mitotic nuclear division / negative regulation of SMAD protein signal transduction / PI5P Regulates TP53 Acetylation / negative regulation of amyloid-beta formation / cytoskeletal motor activity / RHO GTPases Activate NADPH Oxidases / phosphoserine residue binding / postsynaptic cytosol / negative regulation of protein binding / positive regulation of GTPase activity / peptidyl-prolyl cis-trans isomerase activity / regulation of cytokinesis / RNA polymerase II CTD heptapeptide repeat P3 isomerase activity / RNA polymerase II CTD heptapeptide repeat P6 isomerase activity / peptidylprolyl isomerase / Negative regulators of DDX58/IFIH1 signaling / phosphoprotein binding / negative regulation of transforming growth factor beta receptor signaling pathway / synapse organization / negative regulation of ERK1 and ERK2 cascade / regulation of protein stability / negative regulation of protein catabolic process / beta-catenin binding / ISG15 antiviral mechanism / tau protein binding / neuron differentiation / positive regulation of canonical Wnt signaling pathway / positive regulation of protein phosphorylation / regulation of gene expression / midbody / cellular response to hypoxia / Regulation of TP53 Activity through Phosphorylation / response to hypoxia / protein stabilization / nuclear speck / ciliary basal body / glutamatergic synapse / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytosol / cytoplasm類似検索 - 分子機能 : / Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site / PpiC-type peptidyl-prolyl cis-trans isomerase signature. / PPIC-type PPIASE domain / PpiC-type peptidyl-prolyl cis-trans isomerase family profile. / Peptidyl-prolyl cis-trans isomerase, PpiC-type / WW domain / WW/rsp5/WWP domain signature. / WW domain superfamily / WW/rsp5/WWP domain profile. ...: / Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site / PpiC-type peptidyl-prolyl cis-trans isomerase signature. / PPIC-type PPIASE domain / PpiC-type peptidyl-prolyl cis-trans isomerase family profile. / Peptidyl-prolyl cis-trans isomerase, PpiC-type / WW domain / WW/rsp5/WWP domain signature. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / Peptidyl-prolyl cis-trans isomerase domain superfamily類似検索 - ドメイン・相同性 2,3-DIHYDROXY-1,4-DITHIOBUTANE / Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) synthetic construct (人工物) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.7 Å |
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データ登録者 | Rodriguez, I. / Blaha, G. |
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資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) | NS107479 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | CA168517 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | CA285114 | 米国 |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2024 タイトル: Targeted degradation of Pin1 by protein-destabilizing compounds. 著者: Alboreggia, G. / Udompholkul, P. / Rodriguez, I. / Blaha, G. / Pellecchia, M. |
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履歴 | 登録 | 2024年1月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2024年11月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2025年3月5日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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