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Structure paper

TitleTargeted degradation of Pin1 by protein-destabilizing compounds.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 121, Page e2403330121-e2403330121, Year 2024
Publish dateJan 6, 2024 (structure data deposition date)
AuthorsAlboreggia, G. / Udompholkul, P. / Rodriguez, I. / Blaha, G. / Pellecchia, M.
External linksProc. Natl. Acad. Sci. USA / PubMed:39531501
MethodsX-ray diffraction
Resolution1.57 - 1.7 Å
Structure data

PDB-8vjd:
Human R14A Pin1 covalently bound to inhibitor 158F10 in P21 21 21 space group
Method: X-RAY DIFFRACTION / Resolution: 1.57 Å

PDB-8vje:
Human R14A Pin1 covalently bound to inhibitor 158F10
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-8vjf:
Human R14A Pin1 covalently bound to inhibitor 158D9
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-8vjg:
Human R14A Pin1 covalently bound to inhibitor 164A10
Method: X-RAY DIFFRACTION / Resolution: 1.58 Å

Chemicals

ChemComp-P33:
3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL / precipitant*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-DTT:
2,3-DIHYDROXY-1,4-DITHIOBUTANE

PDB-1ach:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsISOMERASE/INHIBITOR / Destabilizing Inhbitor / PPIase / Structure-Activity Relationship / Drug Design / ISOMERASE / ISOMERASE-INHIBITOR complex / Destabilizing Inhibitor / PPIase. Structure-Activity Relationship

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