Entry Database : PDB / ID : 8v2f Structure visualization Downloads & linksTitle Crystal structure of IRAK4 kinase domain with compound 9 ComponentsInterleukin-1 receptor-associated kinase 4 Details Keywords IMMUNE SYSTEM / Kinase important for immune response. ProTAC designFunction / homology Function and homology informationFunction Domain/homology Component
IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding ... IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding / MyD88-dependent toll-like receptor signaling pathway / interleukin-1-mediated signaling pathway / IRAK4 deficiency (TLR2/4) / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / toll-like receptor 4 signaling pathway / toll-like receptor signaling pathway / extrinsic component of plasma membrane / JNK cascade / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / positive regulation of smooth muscle cell proliferation / cytokine-mediated signaling pathway / Interleukin-1 signaling / PIP3 activates AKT signaling / kinase activity / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / cellular response to lipopolysaccharide / positive regulation of canonical NF-kappaB signal transduction / endosome membrane / non-specific serine/threonine protein kinase / intracellular signal transduction / phosphorylation / innate immune response / protein serine kinase activity / protein serine/threonine kinase activity / protein kinase binding / cell surface / magnesium ion binding / extracellular space / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function Interleukin-1 receptor-associated kinase 4 / IRAK4, Death domain / Death-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.09 Å DetailsAuthors Weiss, M.M. / Zheng, X. / Browne, C.M. / Campbell, V. / Chen, D. / Enerson, B. / Fei, X. / Huang, X. / Klaus, C.R. / Li, H. ...Weiss, M.M. / Zheng, X. / Browne, C.M. / Campbell, V. / Chen, D. / Enerson, B. / Fei, X. / Huang, X. / Klaus, C.R. / Li, H. / Mayo, M. / McDonald, A.A. / Paul, A. / Sharma, K. / Shi, Y. / Slavin, A. / Walter, D.M. / Yuan, K. / Zhang, Y. / Zhu, X. / Kelleher, J. / Ji, N. / Walker, D. / Mainolfi, N. Funding support United States, 1items Details Hide detailsOrganization Grant number Country Other private United States
CitationJournal : J.Med.Chem. / Year : 2024Title : Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell LymphomaAuthors: Weiss, M.M. / Zheng, X. / Ji, N. / Browne, C.M. / Campbell, V. / Chen, D. / Enerson, B. / Fei, X. / Huang, X. / Klaus, C.R. / Li, H. / Mayo, M. / McDonald, A.A. / Paul, A. / Rong, H. / ... Authors : Weiss, M.M. / Zheng, X. / Ji, N. / Browne, C.M. / Campbell, V. / Chen, D. / Enerson, B. / Fei, X. / Huang, X. / Klaus, C.R. / Li, H. / Mayo, M. / McDonald, A.A. / Paul, A. / Rong, H. / Sharma, K. / Shi, Y. / Slavin, A. / Walther, D.M. / Yuan, K. / Zhang, Y. / Zhu, X. / Kelleher, J. / Walker, D. / Mainolfi, N. History Deposition Nov 22, 2023 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 3, 2024 Provider : repository / Type : Initial release