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-Structure paper
Title | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 10548-10566, Year 2024 |
Publish date | Nov 21, 2023 (structure data deposition date) |
Authors | Weiss, M.M. / Zheng, X. / Ji, N. / Browne, C.M. / Campbell, V. / Chen, D. / Enerson, B. / Fei, X. / Huang, X. / Klaus, C.R. ...Weiss, M.M. / Zheng, X. / Ji, N. / Browne, C.M. / Campbell, V. / Chen, D. / Enerson, B. / Fei, X. / Huang, X. / Klaus, C.R. / Li, H. / Mayo, M. / McDonald, A.A. / Paul, A. / Rong, H. / Sharma, K. / Shi, Y. / Slavin, A. / Walther, D.M. / Yuan, K. / Zhang, Y. / Zhu, X. / Kelleher, J. / Walker, D. / Mainolfi, N. |
External links | J. Med. Chem. / PubMed:38920289 |
Methods | X-ray diffraction |
Resolution | 2.09 - 2.92 Å |
Structure data | PDB-8v1o: PDB-8v2f: PDB-8v2l: |
Chemicals |
ChemComp-Y9T: ChemComp-GOL: ChemComp-SO4: ChemComp-CL: ChemComp-HOH:
ChemComp-YJU:
ChemComp-YK0: ChemComp-EDO: |
Source |
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Keywords | IMMUNE SYSTEM / Kinase for important for immune response. ProTAC design. / Kinase important for immune response. ProTAC design |