- PDB-8ug1: Crystal structure of KHK-C and compound 13 -
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Open data
ID or keywords:
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Basic information
Entry
Database: PDB / ID: 8ug1
Title
Crystal structure of KHK-C and compound 13
Components
Ketohexokinase
Keywords
SUGAR BINDING PROTEIN / Inhibitor
Function / homology
Function and homology information
Essential fructosuria / ketohexokinase / Fructose catabolism / ketohexokinase activity / regulation of glycogen metabolic process / response to sucrose / response to fructose / fructose metabolic process / response to zinc ion / response to glucose ...Essential fructosuria / ketohexokinase / Fructose catabolism / ketohexokinase activity / regulation of glycogen metabolic process / response to sucrose / response to fructose / fructose metabolic process / response to zinc ion / response to glucose / response to insulin / extracellular exosome / ATP binding / cytoplasm / cytosol Similarity search - Function
Method to determine structure: MOLECULAR REPLACEMENT / Resolution: 1.99→59.9 Å / Cor.coef. Fo:Fc: 0.97 / Cor.coef. Fo:Fc free: 0.96 / SU B: 3.146 / SU ML: 0.086 / Cross valid method: THROUGHOUT / ESU R: 0.117 / ESU R Free: 0.115 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.20477
3344
4.9 %
RANDOM
Rwork
0.17252
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obs
0.17412
64548
99.92 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: BABINET MODEL WITH MASK