登録情報 | データベース: PDB / ID: 8tzr |
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タイトル | Structure of human Wnt3a bound to WLS and CALR |
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要素 | - Calreticulin
- Protein Wnt-3a
- Protein wntless homolog
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キーワード | SIGNALING PROTEIN |
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機能・相同性 | 機能・相同性情報
Wnt signaling pathway involved in forebrain neuroblast division / positive regulation of dermatome development / axis elongation involved in somitogenesis / calcium ion transmembrane transport via low voltage-gated calcium channel / : / positive regulation of collateral sprouting in absence of injury / positive regulation of mesodermal cell fate specification / paraxial mesodermal cell fate commitment / cell proliferation in midbrain / spinal cord association neuron differentiation ...Wnt signaling pathway involved in forebrain neuroblast division / positive regulation of dermatome development / axis elongation involved in somitogenesis / calcium ion transmembrane transport via low voltage-gated calcium channel / : / positive regulation of collateral sprouting in absence of injury / positive regulation of mesodermal cell fate specification / paraxial mesodermal cell fate commitment / cell proliferation in midbrain / spinal cord association neuron differentiation / Formation of the posterior neural plate / Wnt protein secretion / Calnexin/calreticulin cycle / COP9 signalosome assembly / positive regulation of cell-cell adhesion mediated by cadherin / cytolytic granule / Wnt-Frizzled-LRP5/6 complex / positive regulation of Wnt protein secretion / Negative regulation of TCF-dependent signaling by WNT ligand antagonists / synaptic vesicle recycling / Signaling by RNF43 mutants / positive regulation of dendritic cell chemotaxis / WNT ligand biogenesis and trafficking / positive regulation of cardiac muscle cell differentiation / cortical granule / Assembly of Viral Components at the Budding Site / negative regulation of trophoblast cell migration / ATF6 (ATF6-alpha) activates chaperone genes / cell proliferation in forebrain / negative regulation of retinoic acid receptor signaling pathway / cellular response to electrical stimulus / endoplasmic reticulum quality control compartment / nuclear receptor-mediated glucocorticoid signaling pathway / regulation of meiotic nuclear division / secondary palate development / complement component C1q complex binding / Specification of the neural plate border / negative regulation of axon extension involved in axon guidance / sequestering of calcium ion / cementum mineralization / response to glycoside / somatic stem cell division / non-canonical Wnt signaling pathway / co-receptor binding / sarcoplasmic reticulum lumen / cardiac muscle cell fate commitment / presynapse assembly / protein folding in endoplasmic reticulum / hindbrain development / positive regulation of skeletal muscle tissue development / nuclear export signal receptor activity / dorsal/ventral neural tube patterning / negative regulation of dopaminergic neuron differentiation / negative regulation of intracellular steroid hormone receptor signaling pathway / hormone binding / midbrain dopaminergic neuron differentiation / Wnt-protein binding / regulation of postsynapse to nucleus signaling pathway / cardiac muscle cell differentiation / molecular sequestering activity / exocrine pancreas development / mammary gland development / post-anal tail morphogenesis / positive regulation of neural precursor cell proliferation / frizzled binding / positive regulation of hepatocyte proliferation / Class B/2 (Secretin family receptors) / Disassembly of the destruction complex and recruitment of AXIN to the membrane / myoblast differentiation / anterior/posterior axis specification / protein maturation by protein folding / Scavenging by Class F Receptors / Scavenging by Class A Receptors / cortical actin cytoskeleton organization / midbrain development / nuclear androgen receptor binding / inner ear morphogenesis / regulation of synapse organization / cellular response to lithium ion / response to testosterone / negative regulation of fat cell differentiation / B cell proliferation / fat cell differentiation / heart looping / Formation of paraxial mesoderm / skeletal muscle cell differentiation / positive regulation of receptor internalization / hemopoiesis / regulation of presynapse assembly / mesoderm formation / protein localization to nucleus / negative regulation of neuron differentiation / positive regulation of Wnt signaling pathway / smooth endoplasmic reticulum / canonical Wnt signaling pathway / cell fate commitment / endomembrane system / positive regulation of cell cycle / regulation of microtubule cytoskeleton organization / ERAD pathway類似検索 - 分子機能 Wnt-3 protein / Protein wntless / : / Wntless-like, transmembrane domain / Wnt protein, conserved site / Wnt-1 family signature. / Wnt / Wnt, C-terminal domain / wnt family / found in Wnt-1 ...Wnt-3 protein / Protein wntless / : / Wntless-like, transmembrane domain / Wnt protein, conserved site / Wnt-1 family signature. / Wnt / Wnt, C-terminal domain / wnt family / found in Wnt-1 / Calreticulin / Calreticulin family repeated motif signature. / Calreticulin/calnexin / Calreticulin/calnexin, P domain superfamily / Calreticulin/calnexin, conserved site / Calreticulin family / Calreticulin family signature 1. / Calreticulin family signature 2. / Endoplasmic reticulum targeting sequence. / Concanavalin A-like lectin/glucanase domain superfamily類似検索 - ドメイン・相同性 PALMITOLEIC ACID / Chem-POV / Calreticulin / Protein Wnt-3a / Protein wntless homolog類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.5 Å |
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データ登録者 | Qi, X. / Hu, Q. / Li, X. |
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資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM135343 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | HL160487 | 米国 | Welch Foundation | I-1957 | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Structure of human Wnt3a bound to WLS and CALR 著者: Qi, X. / Hu, Q. / Li, X. |
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履歴 | 登録 | 2023年8月27日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年10月18日 | Provider: repository / タイプ: Initial release |
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