Entry Database : PDB / ID : 8tr1 Structure visualization Downloads & linksTitle Crystal structure of trypanosome brucei hypoxanthine guanine phosphopribosyltransferase in complex with [2S,4R]-4-Guanin-9-yl-2-(2- phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine ComponentsHypoxanthine-guanine phosphoribosyltransferase Details Keywords TRANSFERASE / INHIBITOR / COMPLEX / PURINE BASEFunction / homology Function and homology informationFunction Domain/homology Component
hypoxanthine phosphoribosyltransferase / guanine salvage / hypoxanthine metabolic process / guanine phosphoribosyltransferase activity / hypoxanthine phosphoribosyltransferase activity / GMP salvage / nuclear lumen / IMP salvage / glycosome / ciliary plasm ... hypoxanthine phosphoribosyltransferase / guanine salvage / hypoxanthine metabolic process / guanine phosphoribosyltransferase activity / hypoxanthine phosphoribosyltransferase activity / GMP salvage / nuclear lumen / IMP salvage / glycosome / ciliary plasm / purine ribonucleoside salvage / nucleotide binding / magnesium ion binding / cytoplasm / cytosol Similarity search - Function Hypoxanthine phosphoribosyl transferase / Purine/pyrimidine phosphoribosyl transferases signature. / Phosphoribosyl transferase domain / Phosphoribosyltransferase-like / Phosphoribosyltransferase domain Similarity search - Domain/homologyBiological species Trypanosoma brucei (eukaryote)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.46 Å DetailsAuthors Guddat, L.W. Funding support Australia, 1items Details Hide detailsOrganization Grant number Country National Health and Medical Research Council (NHMRC, Australia) 1147368 Australia
CitationJournal : J.Med.Chem. / Year : 2024Title : Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design.Authors : Keough, D.T. / Petrova, M. / King, G. / Kratochvil, M. / Pohl, R. / Dolezelova, E. / Zikova, A. / Guddat, L.W. / Rejman, D. History Deposition Aug 9, 2023 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 8, 2024 Provider : repository / Type : Initial releaseRevision 1.1 May 22, 2024 Group : Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID
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